Additive manufacturing technique-designed metallic porous implants for clinical application in orthopedics

Gao, Chaohua; Wang, Chenyu; Jin, Hui; Wang, Zhonghan; Li, Zuhao; Shi, Chenyu; Leng, Yangming; Yang, Fan; Li, He

doi:10.1039/c8ra04815k

Cited by 67 publications

(37 citation statements)

References 182 publications

(192 reference statements)

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“…Three-dimensional additive manufacturing is an effective tool to form the above surface morphology (Wang et al, 2016). Additive-manufactured implants have been clinically applied, and effective ingrowth of bone to porous implants has been observed (Wang et al, 2017; Gao et al, 2018).…”

Section: Surface Treatment Of Titaniummentioning

confidence: 99%

Titanium–Tissue Interface Reaction and Its Control With Surface Treatment

Hanawa

2019

Front. Bioeng. Biotechnol.

212

149

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Titanium (Ti) and its alloys are widely used for medical and dental implant devices—artificial joints, bone fixators, spinal fixators, dental implant, etc. —because they show excellent corrosion resistance and good hard-tissue compatibility (bone formation and bone bonding ability). Osseointegration is the first requirement of the interface structure between titanium and bone tissue. This concept of osseointegration was immediately spread to dental-materials researchers worldwide to show the advantages of titanium as an implant material compared with other metals. Since the concept of osseointegration was developed, the cause of osseointegration has been actively investigated. The surface chemical state, adsorption characteristics of protein, and bone tissue formation process have also been evaluated. To accelerate osseointegration, roughened and porous surfaces are effective. HA and TiO 2 coatings prepared by plasma spray and an electrochemical technique, as well as alkalinization of the surface, are also effective to improve hard-tissue compatibility. Various immobilization techniques for biofunctional molecules have been developed for bone formation and prevention of platelet and bacteria adhesion. These techniques make it possible to apply Ti to a scaffold of tissue engineering. The elucidation of the mechanism of the excellent biocompatibility of Ti can provide a shorter way to develop optimal surfaces. This review should enhance the understanding of the properties and biocompatibility of Ti and highlight the significance of surface treatment.

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Section: Surface Treatment Of Titaniummentioning

confidence: 99%

Titanium–Tissue Interface Reaction and Its Control With Surface Treatment

Hanawa

2019

Front. Bioeng. Biotechnol.

212

149

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“…More similar clinical cases of the hip joint and pelvic reconstruction by the 3D printed implants have been reported. [11,266,267] As discussed previously, although 3D printed personalized implants have achieved good progress, most of them are focused on metal-based materials, [268] while there are few clinical applications based on 3D printed biodegradable polymers and bioactive ceramics. Therefore, there are still many barriers to the clinical translation of 3D printed scaffolds.…”

Section: Pelvis or Hip Jointmentioning

confidence: 99%

Recent Developments of Biomaterials for Additive Manufacturing of Bone Scaffolds

Zhang

et al. 2020

Adv Healthcare Materials

103

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Recent years have witnessed surging demand for bone repair/regeneration implants due to the increasing number of bone defects caused by trauma, cancer, infection, and arthritis worldwide. In addition to bone autografts and allografts, biomaterial substitutes have been widely used in clinical practice. Personalized implants with precise and personalized control of shape, porosity, composition, surface chemistry, and mechanical properties will greatly facilitate the regeneration of bone tissue and satiate the clinical needs. Additive manufacturing (AM) techniques, also known as 3D printing, are drawing fast growing attention in the fabrication of implants or scaffolding materials due to their capability of manufacturing complex and irregularly shaped scaffolds in repairing bone defects in clinical practice. This review aims to provide a comprehensive overview of recent progress in the development of materials and techniques used in the additive manufacturing of bone scaffolds. In addition, clinical application, pre-clinical trials and future prospects of AM based bone implants are also summarized and discussed.

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“…In parallel with bioceramics, binder jetting of metallic biomaterials is also extensively investigated in the manufacturing of load-bearing medical implants and devices Gao et al, 2018 water as a binder (Meininger et al, 2016). Not limited to the in vitro/ in vivo level coupon samples, in the last 15 years, binder jetting technology is also globally industrialized by ExOne™, HP™ ("Metal Jet" technology) and…”

Section: Fabrication Of Metallic Biomaterials Using Binder Jettingmentioning

confidence: 99%

3D inkjet printing of biomaterials: Principles and applications

Barui

2020

Med Devices & Sens

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Administration; World Health Organization). Devices like dental drills, bowstrings are some of the most ancient footprints of medical advancements even in the primitive human civilization as early as 7000 BC. Designing a medical device with ethical adherence to the regulatory bodies of a particular jurisdiction (not before 1938), followed by conventional manufacturing using FDA/ASTM approved biomaterials were the major practices to meet the demand of global healthcare market till the onset of the 1990 (Food & Drug Administration; Ricles et al., 2018; World Health Organization, 2003). Although its invention in the 1980 s as "stereolithography," additive manufacturing (AM) incepted in the medical sector almost a decade later, to revolutionize the manufacturing landscape (Ventola, 2014). Together with the core concept of digitized fabrication in additive manufacturing/3D printing, the capability of precise regeneration of biologically complex devices/prosthesis attracted the attention of the biomedical community (Barui et al.,

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Additive manufacturing technique-designed metallic porous implants for clinical application in orthopedics

Abstract: The bone defects can be investigated according to 3D data from computed tomography and magnetic resonance imaging, and then treated by CAD software for model and topology optimization to fabricate the customized implants.

Cited by 67 publications

References 182 publications

Titanium–Tissue Interface Reaction and Its Control With Surface Treatment

Titanium–Tissue Interface Reaction and Its Control With Surface Treatment

Recent Developments of Biomaterials for Additive Manufacturing of Bone Scaffolds

3D inkjet printing of biomaterials: Principles and applications

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