Addressing the slow corrosion rate of biodegradable Fe-Mn: Current approaches and future trends

Iron, while attracting less attention than magnesium and zinc, is still one of the best candidates for biodegradable metal stents thanks its biocompatibility, great elastic moduli and high strength. Due to the low corrosion rate, and thus slow biodegradation, iron stents have still not been put into use. While these problems have still not been fully resolved, many studies have been published that propose different approaches to the issues. This brief overview report summarises the latest developments in the field of biodegradable iron-based stents and presents some techniques that can accelerate their biocorrosion rate. Basic data related to iron metabolism and its biocompatibility, the mechanism of the corrosion process, as well as a critical look at the rate of degradation of iron-based systems obtained by several different methods are included. All this illustrates as the title says, what was done within the topic of biodegradable iron-based materials and what more can be done.

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“…Venezuela and Dargush lately wrote a more detailed review only about Fe-Mn biodegradable alloys, to which I refer to those interested [ 138 ].…”

Section: Iron Materials Modificationsmentioning

confidence: 99%

Biodegradable Iron-Based Materials—What Was Done and What More Can Be Done?

2021

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“…Nevertheless, it exhibits too rapid a degradation because of its active chemical property, which usually causes a premature failure before bone healing. Iron (Fe) alloy has also been studied as temporary bone substitute, but it degrades too slowly and limits the new bone regeneration [ 5 , 6 ]. Recently, Zinc (Zn), one new type of biodegradable metal, has drawn intensive attention of researchers [ [7] , [8] , [9] ].…”

Section: Introductionmentioning

confidence: 99%

Microstructure evolution and texture tailoring of reduced graphene oxide reinforced Zn scaffold

Yang

Cheng

Peng

et al. 2021

Bioactive Materials

148

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Zinc (Zn) possesses desirable degradability and favorable biocompatibility, thus being recognized as a promising bone implant material. Nevertheless, the insufficient mechanical performance limits its further clinical application. In this study, reduced graphene oxide (RGO) was used as reinforcement in Zn scaffold fabricated via laser additive manufacturing. Results showed that the homogeneously dispersed RGO simultaneously enhanced the strength and ductility of Zn scaffold. On one hand, the enhanced strength was ascribed to (i) the grain refinement caused by the pinning effect of RGO, (ii) the efficient load shift due to the huge specific surface area of RGO and the favorable interface bonding between RGO and Zn matrix, and (iii) the Orowan strengthening by the homogeneously distributed RGO. On the other hand, the improved ductility was owing to the RGO-induced random orientation of grain with texture index reducing from 20.5 to 7.3, which activated more slip systems and provided more space to accommodate dislocation. Furthermore, the cell test confirmed that RGO promoted cell growth and differentiation. This study demonstrated the great potential of RGO in tailoring the mechanical performance and cell behavior of Zn scaffold for bone repair.

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“…Fe presents interesting mechanical properties that resemble those of SS316L, often used as coronary stent material [9,10], but has a too-low degradation rate [11]. In order to obtain more suitable properties, different candidate alloying elements have been tested.…”

Section: Introductionmentioning

confidence: 99%

Effect of Magnesium Addition and High Energy Processing on the Degradation Behavior of Iron Powder in Modified Hanks’ Solution for Bioabsorbable Implant Applications

Estrada

Multigner

Lieblich

et al. 2022

Metals

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This paper shows the results of applying a combination of high energy processing and magnesium (Mg) as an alloying element in a strategy for enhancing the degradation rate of iron (Fe) for applications in the field of non-permanent medical implants. For this purpose, Fe powder was milled with 5 wt% of Mg (Fe5Mg) and its microstructure and characterized degradation behavior. As-received Fe powder was also milled in order to distinguish between the effects due to high energy processing from those due to the presence of Mg. The powders were prepared by high energy planetary ball milling for 16 h. The results show that the initial crystallite size diminishes from >150 nm to 16 nm for Fe and 46 nm for Fe5Mg. Static degradation tests of loose powder particles were performed in Hanks’ solution. Visual inspection of the immersed powders and the X-ray diffraction (XRD) phase quantification indicate that Fe5Mg exhibited the highest degradation rate followed by milled Fe and as received Fe, in this order. The analysis of degradation products of Fe5Mg showed that they consist on magnesium ferrite and pyroaurite, which are known to present good biocompatibility and low toxicity. Differences in structural features and degradation behaviors of milled Fe and milled Fe5Mg suggest the effective dissolution of Mg in the Fe lattice. Based on the obtained results, it can be said that Fe5Mg powder would be a suitable candidate for non-permanent medical implants with a higher degradation rate than Fe.

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Addressing the slow corrosion rate of biodegradable Fe-Mn: Current approaches and future trends

Cited by 59 publications

References 111 publications

Biodegradable Iron-Based Materials—What Was Done and What More Can Be Done?

Biodegradable Iron-Based Materials—What Was Done and What More Can Be Done?

Microstructure evolution and texture tailoring of reduced graphene oxide reinforced Zn scaffold

Effect of Magnesium Addition and High Energy Processing on the Degradation Behavior of Iron Powder in Modified Hanks’ Solution for Bioabsorbable Implant Applications

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