Adenocarcinoma in situ der Cervix uteri nach 11 Jahren gefolgt von invasivem Adenocarcinom

Büttner, H H; Kyank, H

doi:10.1007/bf00284319

Cited by 8 publications

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“…Progression of AIS to invasive adenocarcinoma has been documented on rare occasions (35)(36)(37)(38). Once a diagnosis of invasion has been made by punch biopsy, the tumor is often irradiated, making assessment of its true size impossible.…”

Section: Natural Historymentioning

confidence: 99%

Early Invasive Adenocarcinoma of the Uterine Cervix

2000

International Journal of Gynecological Pathology

123

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In an attempt to determine the natural history of early invasive adenocarcinoma of the cervix, defined as depth of invasion of 5 mm or less, an extensive review of the literature was undertaken, together with recent unpublished material of the author. Many of the cases had to be extracted from series dealing with microinvasive squamous cell carcinoma. The pons asinorum for the pathologist is the differentiation between adenocarcinoma in situ and early invasion. The criteria for microinvasion are: 1.) obvious invasion to 5 mm or less; 2.) usually complete obliteration of the normal endocervical crypts; 3.) extension beyond the normal glandular field; and 4.) a stromal response characteristic of invasive carcinoma. Not all of these criteria are present in every case. In all 436 cases were collected. Allowing for vagueness of reports, 126 patients were treated by radical hysterectomy, and none had parametrial involvement. No cases of adnexal tumors were found in the 155 patients in whom one or both ovaries were removed. Of the 219 patients with pelvic lymph node dissection, five (2%) had metastasis. There were 15 recurrences and six tumor-related deaths in the 436 patients. Only 21 patients had conization as the only treatment, and none has suffered a recurrence. It appears that early invasive adenocarcinoma behaves in the same way as its squamous counterpart. Cold knife conization is acceptable treatment only when the cone biopsy has been adequately sampled and the margins are free, especially when preservation of fertility is an issue. Loop excision procedures obscure depth of invasion and margins and are not acceptable either for diagnosis or therapy. Multicentricity does not appear to require cylindrical cones. If hysterectomy is contemplated, removal of the adnexa, per se, is unnecessary.

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Section: Natural Historymentioning

confidence: 99%

Early Invasive Adenocarcinoma of the Uterine Cervix

2000

International Journal of Gynecological Pathology

123

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Morphology of adenocarcinomain situ of the uterine cervix: A study of 14 cases

Gloor

Ruzicka

1982

Cancer

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Fourteen cases of adenocarcinoma in situ (ACIS) of the cervix in patients 30 to 52 years old were studied. In its pure form (four cases, ACIS was discovered cytologically, but when associated with a squamous abnormality (ten cases), it was found histologically. Two different types of ACIS were distinguished both histologically and cytologically. The first type, which was similar to the common form reported in the medical literature, predominated in 12 cases, and consisted of cells with hyperchromatic and pseudo-stratified nuclei. The second type, which predominated in two cases, displayed a conspicuous structural disorder with unequal, larger, and often clear nuclei containing enlarged nucleoli.

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Adenocarcinoma of the uterine cervix

Moberg

Einhorn

Silfverswärd

et al. 1986

Cancer

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Between 1958 and 1969, 251 patients were treated at Radiumhemmet in Stockholm for adenocarcinoma of the uterine cervix. The histologic specimens were reevaluated. In the 211 cases of pure adenocarcinoma, the 5-year survival rate was compared with that in the total of cervical epithelial malignancies. The rate was lower in the adenocarcinoma cases, with respective crude 5-year survival rates of 84%, 50%, and 9% in Stages I, II, and III. Two modes of treatment, irradiation alone or irradiation plus radical surgery, were used in Stages IB and IIA. The combined treatment gave significantly improved 5-year survival rates.

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Adenocarcinoma in situ der Cervix uteri nach 11 Jahren gefolgt von invasivem Adenocarcinom

Cited by 8 publications

References 0 publications

Early Invasive Adenocarcinoma of the Uterine Cervix

Early Invasive Adenocarcinoma of the Uterine Cervix

Morphology of adenocarcinomain situ of the uterine cervix: A study of 14 cases

Adenocarcinoma of the uterine cervix

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