Adenoid cystic carcinoma of the breast: mammographic appearance and pathologic correlation.

Santamaría, Gorane; Velasco, Martín; Zanón, Gabriel; Farrús, Blanca; Molina, Rafael; Solé, M; Fernandez, P. L.

doi:10.2214/ajr.171.6.9843312

Cited by 54 publications

(49 citation statements)

References 9 publications

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“…On mammography, the majority of the ACCs of the breast present as high-density masses with irregular or lobulated shape and indistinct margins, which have been described as malignant-appearing (8,(16)(17)(18)(19); these characteristics were consistent with our findings. The sonographic appearance of ACC has been described as a hypoechoic or heterogeneous mass with irregular, lobulated or oval contours and unclear margin (7,8,18).…”

Section: Discussionsupporting

confidence: 91%

Rare imaging appearance of adenoid cystic carcinoma of the breast: A case report

Wang

Liu

et al. 2017

Molecular and Clinical Oncology

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Abstract. Adenoid cystic carcinoma (ACC) of the breast is a rare tumor comprising <0.1% of all breast malignancies. The present study reports the case of a 66-year-old woman who underwent multiple imaging techniques, including mammography, ultrasonography and magnetic resonance imaging (MRI). The patient reported gradual enlargement of a mass in the left breast. Mammography identified a high-density, irregular mass, with nipple retraction. Ultrasonography revealed an irregular, complex cystic and solid mass with an unclear margin in the subareolar region. The internal vascularity was seen on Doppler examination. The lesion on MRI was also mixed cystic and solid, with an irregular shape and irregular margins. The solid part of the lesion appeared heterogeneously isointense on T1-weighted imaging (WI) and a slightly high signal on T2WI, and exhibited internal septations with a low signal on T2WI. Following injection of contrast agent, the enhancement of the solid part was rapid and heterogeneous. The cystic parts of lesion appeared as high-signal on T1WI and T2WI. The tumor infiltrated the left nipple and adjacent skin. The patient underwent a left modified radical mastectomy with axillary lymph node dissection. The pathological examination confirmed the tumor as ACC of the left breast. The axillary lymph nodes were negative for tumor metastasis. Therefore, the differential diagnosis of mixed cystic and solid breast masses with unclear margins and internal septations on T2WI exhibiting delayed enhancement, must include ACC. IntroductionAdenoid cystic carcinoma (ACC) usually occurs in salivary glands, but it has also been described in other organs, including the breast, trachea, uterine cervix, larynx and Bartholin's glands (1-5). However, ACC of the breast is rare (6); thus, there are only a few published studies describing the findings of multiple imaging techniques, and non-specific imaging characteristics have been found on mammography and ultrasonography (7,8). The aim of this study was to present a rare case of proven ACC of the breast and describe its imaging characteristics. Case reportIn April 2016, a 66-year-old woman was admitted to the Sun Yat-sen Memorial Hospital (Guangzhou, China) with a mass in the left breast that had been present for 4 years. The patient reported gradual enlargement of this mass over the last 2 months. Breast examination revealed a palpable mass in the subareolar region measuring 5.0x5.0 cm, with nipple retraction. There was no abnormal nipple discharge or skin redness. Axillary and subclavicular lymph nodes were not palpable. Mammography identified a 6.8x5.0 cm, high-density, irregular mass, with nipple retraction (Fig. 1). Ultrasonography revealed an irregular mass sized 5.0x4.3x5.0 cm, without a clearly circumscribed margin, in the subareolar region. The internal echo of the mass was mixed cystic and solid, with partial enhancement of the posterior echo (Fig. 2). On Doppler examination, internal vascularity was seen. The patient underwent a contrast-enhanced bilateral breast ma...

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Section: Discussionsupporting

confidence: 91%

Rare imaging appearance of adenoid cystic carcinoma of the breast: A case report

Wang

Liu

et al. 2017

Molecular and Clinical Oncology

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“…ACC may present as a cir- © C I C E d i z i o n i I n t e r n a z i o n a l i cumscribed lobulated nodule in mammography. When the limits of the nodular shadow were not clear, microscopic invasion was usually present (30). Our case did not present these characteristics though.…”

Section: Discussioncontrasting

confidence: 55%

“…Tsuboi et al (31) reported that mammary ACC could be distinguished from conventional types of breast carcinoma by dynamic MRI. Santamaria et al (30) discovered that the majority of carcinomas were located in the upper quadrant of the breast or in the area of the areola. ACC may present as a cir- © C I C E d i z i o n i I n t e r n a z i o n a l i cumscribed lobulated nodule in mammography.…”

Section: Discussionmentioning

confidence: 99%

Axillary lymph node metastases in adenoid cystic carcinoma of the breast. A rare finding

SPILIOPOULOS¹

2015

GCHIR

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“…Nevertheless, simple lumpectomy is not recommended due to high local recurrence. Santamaria et al reported high local recurrence rates in patients with simple lumpectomy (17). Leeming et al (18) detected a high local recurrence rate after lumpectomy of 37%.…”

Section: Discussionmentioning

confidence: 99%

Salivary Gland Like Breast Carcinoma/Adenoid Cystic Carcinoma: Case Report

et al. 2014

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Adenoid cystic carcinoma of the breast constitutes approximately 0.1% of all breast tumors. They can be located in the trachea, bronchus, cervix, lacrimal gland, and skin as well as the breast. Tumors in the breast have better prognoses compared to those in other locations. The diagnosis and treatment planning of this tumor is challenging due to its rare incidence. In this article, we presented a case that was diagnosed with adenoid cystic carcinoma of the breast upon pathology evaluation.A 59-year-old female patient was admitted to our clinic due to a mass in her right breast. Her mammography revealed a 1 cm in diameter mass in the upper outer quadrant of the right breast, which was classified as BIRADS 4C (Breast Imaging Reporting and Data System). On magnetic resonance imaging (MRI) the lesion was also reported as BIRADS 4C. The patient underwent breast conserving surgery (BCS), and the pathology result was reported as adenoid cystic carcinoma of the breast. The patient received chemo-radiotherapy in the postoperative period.Adenoid cystic carcinoma of the breast has been first described in the salivary glands. They can be confused with benign lesions both on physical and radiological examinations. Sentinel lymph node biopsy (SLNB) can be used since axillary metastases are rare. Local recurrence and distant metastases are also very rare. Usually, BCS followed by radiotherapy is adequate to obtain local control. In selected patients with a poor prognosis, chemotherapy and hormonal therapy should be added to the treatment.

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Adenoid cystic carcinoma of the breast: mammographic appearance and pathologic correlation.

Cited by 54 publications

References 9 publications

Rare imaging appearance of adenoid cystic carcinoma of the breast: A case report

Rare imaging appearance of adenoid cystic carcinoma of the breast: A case report

Axillary lymph node metastases in adenoid cystic carcinoma of the breast. A rare finding

Salivary Gland Like Breast Carcinoma/Adenoid Cystic Carcinoma: Case Report

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