Adenosine-3′,5′ -Monophosphate: Intracellular Mediator for Methyl Xanthine Stimulation of Gastric Secretion

Harris, John B.; Nigon, Kathleen; Alonso, Darwin O. V.

doi:10.1016/s0016-5085(19)33867-3

Cited by 89 publications

(17 citation statements)

References 18 publications

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“…db-CAMP gave the most definite changes in oxygen consumption, AP accumulation and morphology. Although cAMP is generally considered to be a mediator of secretion (Harris et al 1969, Perrier and Laster 1970, Bersimbaev et al 1971, Kasbekar 1972, Bieck et al 1973, Narumi and Maki 1973, Sung et al 1973, doubts have been raised (Levine andWilson 1971, Mao ef al. 1973) at least for some species.…”

Section: The Gastric Secretagoguesmentioning

confidence: 99%

Effects of Secretagogues on Oxygen Consumption, Aminopyrine Accumulation and Morphology in Isolated Gastric Glands

Berglindh

Helander

Öbrink

1976

Acta Physiologica Scandinavica

326

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A recently developed method to isolate gastric glands from the rabbit gastric mucosa (Berglindh and Obrink 1976) was used to study the effects of some common gastric secretagogues. Three parameters were investigated: 1) Respiratory activity; 2) Intraglandular accumulation of the weak base aminopyrine; 3) Quantitative morphology of the parietal cells. The following substances were tested: Histamine, cAMP, db-cAMP, aminophylline, carbachol and pentagastrin. The strongest effect was obtained with db-cAMP which dose-dependently stimulated the respiration up to 200%, increased the aminopyrine accumulation 80% and altered the parietal cell morphology from a typically resting to a typically stimulated state. cAMP also stimulated the respiration but was about 10 times less effective on a molar basis than the dibutyryl form. Histamine, like db-cAMP, stimulated the respiration in a dose-dependent manner and strongly increased the aminopyrine accumulation. The morphological changes were, however, not of the same magnitude as after db-cAMP. Aminophylline, tested only for respiratory activity, stimulated the oxygen consumpation moderately. Carbachol induced a transient increase in both the oxygen consumption and in the aminopyrine accumulation with a peak value after approximately 15 minutes for both, but gave no significant morphological alterations. Pentagastrin, finally, was incapable of inducing changes in any of the three parameters. Aminopyrine was also found to accumulate approx. 50 times in unstimulated, morphologically resting glands. This seems to indicate that there might be acid sites already in resting glands.

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Section: The Gastric Secretagoguesmentioning

confidence: 99%

Effects of Secretagogues on Oxygen Consumption, Aminopyrine Accumulation and Morphology in Isolated Gastric Glands

Berglindh

Helander

Öbrink

1976

Acta Physiologica Scandinavica

326

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“…Harris et al (6) found that cyclic AMP stimulated acid output in frog gastric mucosa and that AND ACID SECRETION 677 methyl xanthines increased the mucosal content of cyclic AMP and this increase preceded the secretory response. Thus, in frog mucosa there is some evidence for a casual relationship between cyclic AMP and gastric secretion.…”

mentioning

confidence: 98%

“…Haniset al (6) found that, in the frog, gastric acid secretion was stimulated by cyclic AMP and suggested that pentagastrin may mediate its effect via that mechanism. If pentagastrin stimulates gastric acid secretion via cyclic AMP, it would seem likely that acid output in response to pentagastric plus a methyl xanthine would be greater per dose of stimulant than with pentagastrin alone; i.e., the doseresponse curve would shift to the left.…”

mentioning

confidence: 99%

Histamine, Pentagastrin, Methyl Xanthines and Adenyl Cyclase Activity in Acid Secretion

Cooke

Chvasta

Granner

1974

Experimental Biology and Medicine

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“…It is thought to produce this effect by increasing the CAMP content in the gastric mucosa through inhibition of phosphodiesterase (Harris, Nigon & Alonso, 1969;Cano, Isenberg & Grossman, 1976). It is thought to produce this effect by increasing the CAMP content in the gastric mucosa through inhibition of phosphodiesterase (Harris, Nigon & Alonso, 1969;Cano, Isenberg & Grossman, 1976).…”

Section: A J M Seegers and Othersmentioning

confidence: 99%

Gastric erosions induced by analgesic drug mixtures in the rat

Seegers

Jager

Noordwijk

1978

Journal of Pharmacy and Pharmacology

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Gastric erosions after oral administration of analgesics separately and in admixture have been examined in adult rats. After administration of acetylsalicylic acid (aspirin), phenacetin, paracetamol and caffeine as single drugs, gastric erosions were only observed with aspirin. The combination of aspirin with phenacetin did not change, that of aspirin with caffeine significantly increased, and aspirin with paracetamol significantly decreased the incidence of gastric lesions compared with aspirin alone. The results for aspirin with paracetamol did not differ from those for the vehicle. Addition of caffeine to the combination of aspirin and phenacetin caused a significant increase in erosions, but when given with aspirin and paracetamol no erosions occurred. The mechanisms underlying the effects of these drugs on aspirin‐induced erosions are discussed.

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Adenosine-3′,5′ -Monophosphate: Intracellular Mediator for Methyl Xanthine Stimulation of Gastric Secretion

Cited by 89 publications

References 18 publications

Effects of Secretagogues on Oxygen Consumption, Aminopyrine Accumulation and Morphology in Isolated Gastric Glands

Effects of Secretagogues on Oxygen Consumption, Aminopyrine Accumulation and Morphology in Isolated Gastric Glands

Histamine, Pentagastrin, Methyl Xanthines and Adenyl Cyclase Activity in Acid Secretion

Gastric erosions induced by analgesic drug mixtures in the rat

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