Adenovirus respiratory tract infections in infants: a retrospective chart-review study

Jobran, Shaden; Kattan, Randa; Shamaa, Jamal; Marzouqa, Hiyam; Hindiyeh, Musa

doi:10.1016/s0140-6736(18)30409-4

Cited by 20 publications

(22 citation statements)

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“…Of the seven species of HAdV, species B, C and E are most frequently associated with upper respiratory tract infections: species C (types 1, 2, 5) mainly causes mild infections in young children, while species B (types 3, 7, 14, 21) and E (type 4) cause more severe infections in both children and adults [ 19 , 23 , 109 ]. Although HAdV accounts for only ~5% of all childhood respiratory tract infections, it can lead to bronchitis or pneumonia, requiring hospitalization in many cases [ 114 , 115 ]. Species D is associated with conjunctivitis, and species A and F are responsible for causing infections of the gastrointestinal (GI) tract [ 116 ].…”

Section: Hadv-induced Disease and Current Treatment Optionsmentioning

confidence: 99%

“…GI-associated HAdV types are reportedly a major causative agent of disease in children below the age of 5 in low- and middle-income countries [ 117 ]. Overall, HAdV infection can be severe and fatal in some populations, and is a significant burden to society due to the loss of work hours and associated medical expenses [ 115 ].…”

Section: Hadv-induced Disease and Current Treatment Optionsmentioning

confidence: 99%

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Recent Advances in Novel Antiviral Therapies against Human Adenovirus

Saha

Parks

2020

Microorganisms

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Human adenovirus (HAdV) is a very common pathogen that typically causes minor disease in most patients. However, the virus can cause significant morbidity and mortality in certain populations, including young children, the elderly, and those with compromised immune systems. Currently, there are no approved therapeutics to treat HAdV infections, and the standard treatment relies on drugs approved to combat other viral infections. Such treatments often show inconsistent efficacy, and therefore, more effective antiviral therapies are necessary. In this review, we discuss recent developments in the search for new chemical and biological anti-HAdV therapeutics, including drugs that are currently undergoing preclinical/clinical testing, and small molecule screens for the identification of novel compounds that abrogate HAdV replication and disease.

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Section: Hadv-induced Disease and Current Treatment Optionsmentioning

confidence: 99%

Section: Hadv-induced Disease and Current Treatment Optionsmentioning

confidence: 99%

Recent Advances in Novel Antiviral Therapies against Human Adenovirus

Saha

Parks

2020

Microorganisms

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“…HAdV has caused respiratory tract adenovirus outbreaks in Jiangsu and Taiwan provinces of China, as well as in Korea, Singapore and Malaysia [5–7]. Such infections have been estimated to cause 2–5% of RTIs overall and 4–10% of all pneumonias in City of Bethlehem [8].…”

Section: Introductionmentioning

confidence: 99%

Human adenovirus among hospitalized children with respiratory tract infections in Beijing, China, 2017–2018

Yao

Wang

Wei

et al. 2019

Virol J

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Background Human adenoviruses (HAdVs) cause a wide range of diseases. However, the genotype diversity and epidemiological information relating to HAdVs among hospitalized children with respiratory tract infections (RTIs) is limited. Here, we describe the epidemiology and genotype distribution of HAdVs associated with RTIs in Beijing, China. Methods Nasopharyngeal aspirates (NPA) were collected from hospitalized children with RTIs from April 2017 to March 2018. HAdVs were detected by a TaqMan-based quantitative real-time polymerase chain reaction (qPCR) assay, and the hexon gene was used for phylogenetic analysis. Epidemiological data were analyzed using statistical product and service solutions (SPSS) 21.0 software. Results HAdV was detected in 72 (5.64%) of the 1276 NPA specimens, with most (86.11%, 62/72) HAdV-positives cases detected among children < 6 years of age. HAdV-B3 (56.06%, 37/66) and HAdV-C2 (19.70%, 13/66) were the most frequent. Of the 72 HAdV-infected cases, 27 (37.50%) were co-infected with other respiratory viruses, most commonly parainfluenza virus (12.50%, 9/72) and rhinovirus (9.72%, 7/72). The log number of viral load ranged from 3.30 to 9.14 copies per mL of NPA, with no significant difference between the HAdV mono- and co-infection groups. The main clinical symptoms in the HAdV-infected patients were fever and cough, and 62 (86.11%, 62/72) were diagnosed with pneumonia. Additionally, HAdVs were detected throughout the year with a higher prevalence in summer. Conclusions HAdV prevalence is related to age and season. HAdV-B and HAdV-C circulated simultaneously among the hospitalized children with RTIs in Beijing, and HAdV-B type 3 and HAdV-C type 2 were the most frequent.

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“…Furthermore, a great number of patients with ADV infection presented with clinical symptoms very common among patients with pertussis such as whooping (51.1%), shortness of breath (43.4%) and vomiting (47.5%). Similarly, a recent study has reported that gastrointestinal symptoms and difficulty breathing are among the most common type of presentations in children [35]. Additionally, ADV has been historically identified as a major cause of pertussis-like syndrome, which results in the likelihood of a pertussis misdiagnosis in the absence of laboratory [36][37][38].…”

Section: Discussionmentioning

confidence: 99%

Identfication of viral and bacterial etiologic agents of the pertussis-like syndrome in children under 5 years old hospitalized

et al. 2019

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BackgroundAcute respiratory infections (ARIs) represent an important cause of morbidity and mortality in children, remaining a major public health concern, especially affecting children under 5 years old from low-income countries. Unfortunately, information regarding their epidemiology is still limited in Peru.MethodsA secondary data analysis was performed from a previous cross-sectional study conducted in children with a probable diagnosis of Pertussis from January 2010 to July 2012. All samples were analyzed via Polymerase Chain Reaction (PCR) for the following etiologies: Influenza-A, Influenza-B, RSV-A, RSV-B, Adenovirus, Parainfluenza 1 virus, Parainfluenza 2 virus, Parainfluenza 3 virus, Mycoplasma pneumoniae and Chlamydia pneumoniae.ResultsA total of 288 patients were included. The most common pathogen isolated was Adenovirus (49%), followed by Bordetella pertussis (41%) from our previous investigation, the most prevelant microorganisms were Mycoplasma pneumonia (26%) and Influenza-B (19.8%). Coinfections were reported in 58% of samples and the most common association was found between B. pertussis and Adenovirus (12.2%).ConclusionsThere was a high prevalence of Adenovirus, Mycoplasma pneumoniae and other etiologies in patients with a probable diagnosis of pertussis. Despite the presence of persistent cough lasting at least two weeks and other clinical characteristics highly suspicious of pertussis, secondary etiologies should be considered in children under 5 years-old in order to give a proper treatment.Electronic supplementary materialThe online version of this article (10.1186/s12879-019-3671-6) contains supplementary material, which is available to authorized users.

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Adenovirus respiratory tract infections in infants: a retrospective chart-review study

Cited by 20 publications

References 0 publications

Recent Advances in Novel Antiviral Therapies against Human Adenovirus

Recent Advances in Novel Antiviral Therapies against Human Adenovirus

Human adenovirus among hospitalized children with respiratory tract infections in Beijing, China, 2017–2018

Identfication of viral and bacterial etiologic agents of the pertussis-like syndrome in children under 5 years old hospitalized

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