Adherence of Dermatophyte Microconidia and Arthroconidia to Human Keratinocytes In Vitro

Sacha Inchi Oil (Plukenetia volubilis L.), effect on adherence of Staphylococus aureus to human skin explant and keratinocytes in vitro

“…Finally, in an early study, Zurita and Hay (1987) suggested that the effect of fatty acids on adherence, between dermatophyte conidia and human keratinocytes, could be an important regulatory factor. It would therefore be interesting to test the activity of SIO against mycosis, because skin mycoses are a worldwide health concern particularly in tropical area (Lupi et al, 2005).…”

Genetic susceptibility to dermatophytosis

“…The immune defect would presumably have to be specific for T. concentricum as there is no evidence that affected individuals show increased susceptibiity to other infections. Another mechanism might be through an effect on the early phase of fungal attack such as adherence of fungal elements to the stratum corneum of skin which might well be altered by the expression of different receptors on keratinocytes determined by a simple genetic trait (26). The mechanism is important as the existence of a specific immune defect determining susceptibility to dermatophytosis would be difficult to overcome whereas an increase in keratinocyte adhesin capacity might be amenable to simple blockade.…”

Mechanical Properties of Healthy and ex vivo Onychomycosis Nails and the Influence of a Porphyrin-propylene Glycol Antifungal Formulation

“…at room temperature (RT). Microconidia suspensions were prepared as described previously and stored in liquid nitrogen for no longer than 6 months [9,10]. Counting the number of colony forming units (cfu) on malt extract agar (MEA, Oxoid, Hampshire, UK) was used as a viability check.…”