Adherence to antiretroviral therapy among people living with HIV/AIDS in northeastern Brazil: a cross-sectional study

Abstract

BACKGROUND: Nonadherence to antiretroviral therapy (ART) may lead to viral replication and development of antiretroviral resistance. OBJECTIVE: To identify the factors associated with nonadherence to ART among people living with the human immunodeficiency virus (HIV)/acquired immunodeficiency syndrome (AIDS) (PLWHA). DESIGN AND SETTING: Cross-sectional study in a tertiary-level hospital in northeastern Brazil. METHODS: Intake of less than 90% of the antiretroviral drugs prescribed in the last week prior to the interview was defined as nonadherence. Intake was evaluated using a questionnaire. Descriptive and multivariate analyses were conducted on the study population, with estimation of the respective odds ratios and 95% confidence intervals. RESULTS: The prevalence of nonadherence was 28.4%. Significant associations were found regarding the following variables: age less than 35 years, smoking, sedentary lifestyle, lack of medication and lack of knowledge regarding the patient's HIV status, on the part of the patient's partner or family. CONCLUSIONS: Encouragement of adherence to antiretroviral therapy is one of the fundamental pillars of treatment for HIV-infected patients. The high proportion of nonadherence (28.4%) and the predictive factors related to this indicate that it is necessary to improve patients' adherence to antiretroviral therapy.

Levels of Adherence and Associated Factors Among Children on ART Over Time in Northwest, Ethiopia: Evidence from a Multicenter Follow-Up Study

“… 31 , 45 Moreover, the level of adherence to ART is also higher than the studies conducted in Peru (41.7%), and Brazil (71.6%). 46 , 47 On the other hand, this finding is lower than the studies conducted in Debre Birhan (95.5%) and Nepal (87.4%). 32 , 48 …”

Evaluation of the Sociodemographic, Behavioral and Clinical Influences on Complete Antiretroviral Therapy Adherence Among HIV-Infected Adults Receiving Medical Care in Houston, Texas

“…31 Younger PLWH had been numerously reported to be at higher risks of non-adherence and were often subjected to unique barriers in maintaining high antiretroviral adherence. [52][53][54] For instance, adolescents and young PLWH were less likely to be retained in care, more likely to delay initiation of ART, and had lower rates of virologic suppression, all of which had been associated with poorer antiretroviral adherence. [55][56][57] Conversely, poor adherence in longer HIV-infected adults may be related to modifiable patient-related factors such as access to insurance, employment, and mental illness, which may affect PLWH ability to maintain care.…”

Avaliação da adesão a terapia antirretroviral com esquemas contendo dolutegravir em um município de Goiás

“…CV detectável em pacientes aderentes sugerem falha da adesão à TARV, e consequentemente falha virológica, que é definida como CV detectável após seis meses do início ou da modificação do tratamento, ou rebote da CV em indivíduos que haviam atingido supressão viral sob tratamento (BRASIL, 2018). Ou seja, existem mais pacientes que mantém a baixa adesão do que foi detectado por meio CEAT-VIH, pois a CV é um importante marcador da qualidade da adesão ao tratamento (Soares, Brito, Lima, & Lapa, 2019).…”