Adhesion of Cells and Tissues to Bioabsorbable Polymeric Materials: Scaffolds, Surgical Tissue Adhesives and Anti-adhesive Materials

Suzuki, Shuko; Ikada, Yoshito

doi:10.1163/016942410x507920

Cited by 11 publications

(9 citation statements)

References 83 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…52,80−83 As examples, formaldehyde, the simplest form of aldehydes, and glutaraldehyde, or dialdehyde, are often used with gelatin-resorcinol. 80,81 The lysine residues of gelatin are bridged through formaldehyde and glutaraldehyde to form a hydrogel adhesive. The resorcinol groups are also involved in matrix cross-linking through electrophilic aromatic substitution.…”

Section: Wet Adhesion -Interfacing With the Chemistry Of Tissuesmentioning

confidence: 99%

Polymeric Tissue Adhesives

2021

View full text Add to dashboard Cite

Polymeric tissue adhesives provide versatile materials for wound management and are widely used in a variety of medical settings ranging from minor to life-threatening tissue injuries. Compared to the traditional methods of wound closure (i.e., suturing and stapling), they are relatively easy to use, enable rapid application, and introduce minimal tissue damage. Furthermore, they can act as hemostats to control bleeding and provide a tissue-healing environment at the wound site. Despite their numerous current applications, tissue adhesives still face several limitations and unresolved challenges (e.g., weak adhesion strength and poor mechanical properties) that limit their use, leaving ample room for future improvements. Successful development of next-generation adhesives will likely require a holistic understanding of the chemical and physical properties of the tissue-adhesive interface, fundamental mechanisms of tissue adhesion, and requirements for specific clinical applications. In this review, we discuss a set of rational guidelines for design of adhesives, recent progress in the field along with examples of commercially available adhesives and those under development, tissue-specific considerations, and finally potential functions for future adhesives. Advances in tissue adhesives will open new avenues for wound care and potentially provide potent therapeutics for various medical applications.

show abstract

Section: Wet Adhesion -Interfacing With the Chemistry Of Tissuesmentioning

confidence: 99%

Polymeric Tissue Adhesives

2021

View full text Add to dashboard Cite

show abstract

“…Furthermore, the adhesion strength of polysaccharide adhesives (approximately 10 kPa) is still not strong enough. 12 In recent years, a considerable number of researchers have paid attention to the biological adhesion behavior to develop bionic adhesives. 13−16 Blue mussel, a mollusk belonging to the colony-forming bivalve genus Mytilus, is common in many marine environments and coastal areas.…”

Section: Introductionmentioning

confidence: 99%

“…In particular, the cured cyanoacrylate is quite stiff with low tissue compliance. Tissue adhesives derived from natural sources possess good biocompatibility but weak mechanical properties (below 15 kPa) and immunological risks. , As reported in the literature, tissue adhesives, including fibrin sealant, tissue adhesive gelatin, and albumin, are all driven by mammals along with the risk of carrying viruses. Moreover, polysaccharide adhesives, such as chitin and chitosan, dextran, or chondroitin, have some drawbacks, including easy dissolution and fast degradation.…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Mussel-Inspired, Injectable Polyurethane Tissue Adhesives Demonstrate In Situ Gel Formation under Mild Conditions

Zhao

Hao

Wang

et al. 2021

ACS Appl. Bio Mater.

View full text Add to dashboard Cite

Tissue adhesives are widely desired in surgical wound closure and interfacial modification of medical devices. However, poor adhesive strength, low mechanical compliance, high costs, and biotoxicity of traditional adhesives limit their biomedical applications. In this work, we fabricated a class of mussel-inspired polyurethane adhesives (MPUAs) with robust properties, including in situ gel formation under mild conditions, accommodation of intricate wounds, strong adhesion, and good biocompatibility. Dopamine-modified lysine (LDA), as a chain extender, was incorporated into linear polyurethane as a crucial adhesive unit, and biologically sourced lysine was used as a mild curing agent for in situ gel. The premixed polyurethane adhesives can be fluently injected and can fill irregular and complicated defects. After mixing for several minutes, the adhesives can strongly bond multiple substrates, such as metallic materials, organic materials, and inorganic nonmetallic materials. In particular, they can strongly cohere the fresh (wet) biological tissues with a ductile interface, and the lap shear strength (24.5 ± 2.0 kPa) of the MPUAs was six times higher than that of the commercial fibrin glue. Moreover, the bursting pressure of MPUAs on the porcine aorta was 108.2 ± 3.8 mmHg, which can satisfy most of the surgical requirements (≤20 mmHg). Given its good biocompatibility, this system would provide potential applications in clinical surgery and biological coatings of medical devices.

show abstract

“… 19 Several biomaterials, such as polyethylene glycol, were developed as active methods to prevent postsurgery adhesion, working mainly as a physical barrier. 20 Very few examples were described where elastomeric proteins or derivatives were used as antiadhesive biomaterials. 21 The aim of the present work is the design and production of an elastomeric protein-inspired hydrogel characterized by softness and elasticity and devoid of cell-adhesive sequences to be proposed as an antiadhesive material.…”

Section: Introductionmentioning

confidence: 99%

Soft Hydrogel Inspired by Elastomeric Proteins

Pepe

Maio

Bracalello

et al. 2021

ACS Biomater. Sci. Eng.

View full text Add to dashboard Cite

Elastin polypeptides based on -VPGVG- repeated motifs are widely used in the production of biomaterials because they are stimuli-responsive systems. On the other hand, glycine-rich sequences, mainly present in tropoelastin terminal domains, are responsible for the elastin self-assembly. In a previous study, we have recombinantly expressed a chimeric polypeptide, named resilin, elastin, and collagen (REC), inspired by glycine-rich motifs of elastin and containing resilin and collagen sequences as well. Herein, a three-block polypeptide, named (REC) 3 , was expressed starting from the previous monomer gene by introducing key modifications in the sequence. The choice was mandatory because the uneven distribution of the cross-linking sites in the monomer precluded the hydrogel production. In this work, the cross-linked polypeptide appeared as a soft hydrogel, as assessed by rheology, and the linear un-cross-linked trimer self-aggregated more rapidly than the REC monomer. The absence of cell-adhesive sequences did not affect cell viability, while it was functional to the production of a material presenting antiadhesive properties useful in the integration of synthetic devices in the body and preventing the invasion of cells.

show abstract

Adhesion of Cells and Tissues to Bioabsorbable Polymeric Materials: Scaffolds, Surgical Tissue Adhesives and Anti-adhesive Materials

Cited by 11 publications

References 83 publications

Polymeric Tissue Adhesives

Polymeric Tissue Adhesives

Mussel-Inspired, Injectable Polyurethane Tissue Adhesives Demonstrate In Situ Gel Formation under Mild Conditions

Soft Hydrogel Inspired by Elastomeric Proteins

Contact Info

Product

Resources

About