Adhesion phenotypes of pigs of Chinese and Western breeds and a White Duroc-Erhualian crossbreed with regard to susceptibility to enterotoxigenic Escherichia coli with fimbrial adhesins K99, 987P, and F41

Yan, Xueming; Huang, Xiang; Ren, Jun; Ouyang, Jing; Yang, Ming; Han, Pengfei; Huang, Lusheng

doi:10.2460/ajvr.72.1.80

Cited by 2 publications

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References 26 publications

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“…The F 2 resource population consist of 1912 F 2 animals that were derived from two White Duroc and 17 Erhualian as founders (Guo et al, 2009). The 15 outbred populations represent a broad genetic background of Chinese and Western pigs (Yan et al, 2011) (Table 1). In this study, 835 F 2 animals at age of 240 days and 287 outbred piglets at 6-8 weeks old were recorded for their ETEC adhesion phenotypes.…”

Section: Methodsmentioning

confidence: 99%

A genome-wide association analysis for susceptibility of pigs to enterotoxigenic Escherichia coli F41

Yang

Zhang

et al. 2016

Animal

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Enterotoxigenic Escherichia coli (ETEC) is a type of pathogenic bacteria that cause diarrhea in piglets through colonizing pig small intestine epithelial cells by their surface fimbriae. Different fimbriae type of ETEC including F4, F18, K99 and F41 have been isolated from diarrheal pigs. In this study, we performed a genome-wide association study to map the loci associated with the susceptibility of pigs to ETEC F41 using 39454 single nucleotide polymorphisms (SNPs) in 667 F 2 pigs from a White Duroc × Erhualian F 2 cross. The most significant SNP (ALGA0022658, P = 5.59 × 10 −13 ) located at 6.95 Mb on chromosome 4. ALGA0022658 was in high linkage disequilibrium ( r 2 > 0.5) with surrounding SNPs that span a 1.21 Mb interval. Within this 1.21 Mb region, we investigated ZFAT as a positional candidate gene. We re-sequenced cDNA of ZFAT in four pigs with different susceptibility phenotypes, and identified seven coding variants. We genotyped these seven variants in 287 unrelated pigs from 15 diverse breeds that were measured with ETEC F41 susceptibility phenotype. Five variants showed nominal significant association ( P < 0.05) with ETEC F41 susceptibility phenotype in International commercial pigs. This study provided refined region associated with susceptibility of pigs to ETEC F41 than that reported previously. Further works are needed to uncover the underlying causal mutation(s).

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Section: Methodsmentioning

confidence: 99%

A genome-wide association analysis for susceptibility of pigs to enterotoxigenic Escherichia coli F41

Yang

Zhang

et al. 2016

Animal

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Integrative network analysis revealed molecular mechanisms of urine urea output in lactating dairy cows: Potential solutions to reduce environmental nitrate contamination

et al. 2021

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Adhesion phenotypes of pigs of Chinese and Western breeds and a White Duroc-Erhualian crossbreed with regard to susceptibility to enterotoxigenic Escherichia coli with fimbrial adhesins K99, 987P, and F41

Abstract: Results suggested that the ETEC F41 strain, but not the K99 or 987P strain, might be a cause of diarrhea in 6- to 8-week-old pigs in China.

Cited by 2 publications

References 26 publications

A genome-wide association analysis for susceptibility of pigs to enterotoxigenic Escherichia coli F41

A genome-wide association analysis for susceptibility of pigs to enterotoxigenic Escherichia coli F41

Integrative network analysis revealed molecular mechanisms of urine urea output in lactating dairy cows: Potential solutions to reduce environmental nitrate contamination

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