Adipokines NUCB2/Nesfatin-1 and Visfatin as Novel Inflammatory Factors in Chronic Obstructive Pulmonary Disease

Abstract

COPD (chronic obstructive pulmonary disease) is a common lung disease characterized by airflow limitation and systemic inflammation. Recently, adipose tissue mediated inflammation has gathered increasing interest in the pathogenesis of the disease. In this study, we investigated the role of novel adipocytokines nesfatin-1 and visfatin in COPD by measuring if they are associated with the inflammatory activity, lung function, or symptoms. Plasma levels of NUCB2/nesfatin-1 and visfatin were measured together with IL-6, IL-8, TNF-α, and MMP-9, lung function, exhaled nitric oxide, and symptoms in 43 male patients with emphysematous COPD. The measurements were repeated in a subgroup of the patients after four weeks' treatment with inhaled fluticasone. Both visfatin and NUCB2/nesfatin-1 correlated positively with plasma levels of IL-6 (r = 0.341, P = 0.027 and rho = 0.401, P = 0.008, resp.) and TNF-α (r = 0.305, P = 0.052 and rho = 0.329, P = 0.033, resp.) and NUCB2/nesfatin-1 also with IL-8 (rho = 0.321, P = 0.036) in patients with COPD. Further, the plasma levels of visfatin correlated negatively with pulmonary diffusing capacity (r = −0.369, P = 0.016). Neither of the adipokines was affected by fluticasone treatment and they were not related to steroid-responsiveness. The present results introduce adipocytokines NUCB2/nesfatin-1 and visfatin as novel factors associated with systemic inflammation in COPD and suggest that visfatin may mediate impaired pulmonary diffusing capacity.

Nesfatin-1 and Vitamin D levels may be associated with systolic and diastolic blood pressure values and hearth rate in polycystic ovary syndrome

“…However, it is known that cytokines stimulate the production of N1 from adipose tissue [32]. A strong correlation has been reported between N1 and pro-inflammatory cytokines [32,33].…”

“…However, it is known that cytokines stimulate the production of N1 from adipose tissue [32]. A strong correlation has been reported between N1 and pro-inflammatory cytokines [32,33]. There are studies reporting the association between the low N1 levels and the elevated systolic and diastolic BP [34].…”

“…Although basal N1 levels have an anti-inflammatory effect, its low-level increases inflammation, possibly leading to the development of hypertension. However, high N1 levels may also lead to hypertension by increasing inflammation and endothelial dysfunction [32,33]. N1 has been reported to play a role in the development of hypertension, especially in obese subjects [35].…”

Inflammation in sleep apnea: An update

“…Nesfatin-1 is present in chrondrocytes, where it augments the release of inflammatory mediators (including IL-8, IL-6, and MIP-1a) induced by IL-1. In patients with COPD, Nesfatin-1 positively correlated with serum IL-6, IL-8 and TNF-α [71], although levels of Nesfatin-1 did not change after treatment with inhaled corticosteroids. Paradoxically, Nesfatin-1 decreased inflammation in rats subjected to traumatic brain injury [72].…”

Effect of Nesfatin-1 on Ischaemia-Reperfusion Injury in Isolated Heart of Albino Rats

“…Furthermore, Nesfatin-1 was reported to be a new anti-inflammatory factor in case of systemic inflammation in chronic obstructive pulmonary disease (COPD) [49] and in obstructive sleep apnea syndrome [50] . In addition, in post conditioning group (group III); Nesfatin-1 significantly decreased the percentage of necrotic tissue to the whole LV mass.…”