Adiponectin as a marker of complications in type I diabetes

Habeeb, Nevin M.; Youssef, Omneya Ibrahim; Saab, Azza Abdel Rahman; El-Hadidi, Eman S

doi:10.1007/s13312-012-0041-5

Cited by 18 publications

(12 citation statements)

References 16 publications

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“…There were similar observations in obese diabetic boys in an earlier study published in Indian Pediatrics [7]. In this issue of the journal, Habeeb, et al provide another observation of adiponectin as a marker for complications in children with T1DM [8].…”

supporting

confidence: 65%

Editorials

Menon¹,

Gaur

Bhattacharya

et al. 2012

Indian Pediatr

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supporting

confidence: 65%

Editorials

Menon¹,

Gaur

Bhattacharya

et al. 2012

Indian Pediatr

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“…Conversely, adiponectin levels correlate negatively with visceral and subcutaneous fat areas [62, 63] with low adiponectin levels associated with obesity, type 2 diabetes, and insulin resistance [59]. An increased level of adiponectin was found in diabetic and nondiabetic subjects with impaired kidney function as well as in type 1 diabetic patients without complications and particularly in those with diabetic nephropathy [62–65]. In our study, there were no statistically significant differences in BMI between, the investigated groups according to DR status.…”

Section: Discussionmentioning

confidence: 99%

Body Mass Index and Retinopathy in Type 1 Diabetic Patients

Kaštelan

Rabatić

Tomić

et al. 2014

International Journal of Endocrinology

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Aim. To investigate whether body mass index (BMI) independently or in correlation with other risk factors is associated with diabetic retinopathy (DR) progression. Methods. The study included 176 patients with type 1 diabetes divided into three groups according to DR status: group 1 (no retinopathy; n = 86), group 2 (mild/moderate nonproliferative DR; n = 33), and group 3 (severe/very severe NPDR or proliferative DR; n = 57). Results. A significant deterioration of HbA1c, an increase in total cholesterol, systolic, diastolic blood pressure, and diabetic nephropathy with the progression of retinopathy were found. DR progression was correlated with diabetes duration, HbA1c, hypertension, total cholesterol, and the presence of nephropathy. In patients without nephropathy, statistical analyses showed that progression of retinopathy increased significantly with higher BMI (gr. 1: 24.03 ± 3.52, gr. 2: 25.36 ± 3.44, gr. 3: 26.93 ± 3.24; P < 0.01). A positive correlation between BMI and a significant deterioration of HbA1c, an increase in cholesterol, triglycerides, and hypertension was observed. Conclusion. BMI in correlation with HbA1c, cholesterol, and hypertension appears to be associated with the progression of DR in type 1 diabetic patients without nephropathy. However, additional studies are required to investigate the pathogenic role of obesity and weight loss in retinal diabetic complications particularly relating to nephropathy.

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“…On the contrary, another study showed that, serum adiponectin level in patients with poor glycemic control is higher than in patients with good glycemic control and has direct association with HbA 1 % in type 1 diabetics, so it can be used as a good marker for metabolic state among these patients [ 8 ]. Also other studies found such correlation with the HbA 1 % [ 4 , 24 ]. A study done by Wang et al, [ 25 ] put an explanation for the effect of glycemic control on serum adiponectin levels.…”

Section: Discussionmentioning

confidence: 57%

Study of Adiponectin Level in Diabetic Adolescent Girls in Relation to Glycemic Control and Complication of Diabetes

Dayem

Nazif

EI-Kader

et al. 2015

Open Access Maced J Med Sci

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AIM:To study the relation between adiponectin level with glycemic control and complication of diabetes.PATIENTS AND METHODS:The study included 40 female adolescent type 1 diabetic patients and 40 healthy volunteers of the same age and sex. Blood sample was taken for assessment of glycosylated hemoglobin, lipid profile and adiponectine. Urine sample was taken for assessment of albumin/creatinine ratio.RESULTS:Diabetic patients had a significantly higher diastolic blood pressure, triglyceride, total cholesterol, LDL and adiponectin than controls. Patients with diabetes complication had a significant lower BMI and HDL. On the other hand, they had higher disease duration, total cholesterol, HbA1, albumin/creatinine ratio and adiponectin. Patients with microalbuminuria had a lower BMI, higher disease duration, diastolic blood pressure and adiponectin. Patients with diabetic retinopathy had higher disease duration, insulin dose, HbA1, microalbuminuria and adiponectin. Adiponectin in diabetic patients had a significant negative correlation with BMI and positive correlation with systolic blood pressure and microlabuminuria.CONCLUSION:Serum adiponectin level is high in adolescent type 1 diabetic girls. It can be used as a predictor of diabetes complications rather than a sensitive biochemical marker for glycemic control.

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Adiponectin as a marker of complications in type I diabetes

Abstract: Elevated adiponectin level in children and adolescents with type I diabetes indicates poor glycemic control and development of complications, especially nephropathy.

Cited by 18 publications

References 16 publications

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Body Mass Index and Retinopathy in Type 1 Diabetic Patients

Study of Adiponectin Level in Diabetic Adolescent Girls in Relation to Glycemic Control and Complication of Diabetes

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