2011
DOI: 10.1210/jc.2011-1567
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Adipose Tissue Extracellular Matrix and Vascular Abnormalities in Obesity and Insulin Resistance

Abstract: The adipose tissue from obese/insulin-resistant subjects has fewer capillaries and more large vessels as compared with lean subjects. The ECM of adipose tissue may play an important role in regulating the expandability as well as angiogenesis of adipose tissue.

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Cited by 245 publications
(212 citation statements)
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“…Collagen V consists of about 1-5% of the total collagens in healthy tissue; however, it increases during fibrogenesis in liver (31) and lung (20), playing an anchoring role between collagen fibrils (31,32). Collagen V is also reported to increase in obese adipose tissue (10,25), especially in fibrotic areas (26). These facts and our findings suggest that collagen V induced by MCP-6 is associated with adipose tissue fibrosis.…”
Section: Discussionsupporting
confidence: 69%
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“…Collagen V consists of about 1-5% of the total collagens in healthy tissue; however, it increases during fibrogenesis in liver (31) and lung (20), playing an anchoring role between collagen fibrils (31,32). Collagen V is also reported to increase in obese adipose tissue (10,25), especially in fibrotic areas (26). These facts and our findings suggest that collagen V induced by MCP-6 is associated with adipose tissue fibrosis.…”
Section: Discussionsupporting
confidence: 69%
“…On the other hand, collagen 4 mRNA expression was significantly suppressed by anti-MCP-6 antibody; however, it was neither induced by recombinant MCP-6 in NIH-3T3 cells and adipose tissue nor increased in 15-wk-old obese adipose tissue. Collagen IV is a basement membrane protein that is observed in the surroundings of adipocytes, not in fibrotic areas (26). These results suggest that collagen IV may not be involved in adipose tissue fibrosis.…”
Section: Discussionmentioning
confidence: 73%
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“…Hypoxia in adipose tissue results in the stabilization of hypoxiainducible factor 1␣ (HIF-1␣), which in turn induces the expression of fibrotic proteins such as lysyl oxidase (LOX), elastin, collagen I and III, tissue inhibitor of matrix metalloproteinase-1 (TIMP-1), and connective tissue growth factor (CTGF) (115,317). In this sense, obese subjects exhibit reduced elastin and increased collagen I, III, V, and VI, and CTGF in adipose tissue, with visceral fat showing more fibrotic strokes than subcutaneous adipose tissue (61,301,302). Preadipocytes constitute the major source of collagen I, fibronectin, and tenascin C, which are involved in the formation of the collagen network (61,125,153).…”
Section: Recruitment Of Proinflammatory Immune Cells In Obesity Perpementioning
confidence: 99%
“…Platelet endothelial cell adhesion molecule-1 (CD31/ PECAM-1) is a cell-cell adhesion molecule that is expressed on circulating platelets, on leukocytes, and at the intercellular junctions of vascular endothelial cells, where it mediates the interactions of these cells during the process of transendothelial cell migration, thrombosis, wound healing, and angiogenesis (in cancer, stroke and others). [32][33][34] VEGF promotes adult angiogenesis for re-establishment of blood flow following ischemic damage. 35) Administration of exogenous VEGF following stroke results in reduced neuronal cell death, increased angiogenesis and increased vascular permeability.…”
Section: Discussionmentioning
confidence: 99%