Adjuvant effects of curcumin as a photoantimicrobial or irrigant in the non-surgical treatment of periodontitis: Systematic review and meta-analysis

Souza, Eduardo Quintão Manhanini; Rocha, Tiago Esgalha da; Toro, Luan Felipe; Guiati, Isabella Zacarin; Freire, Jéssica de Oliveira Alvarenga; Ervolino, Edílson; Brandini, DA; Garcia, Valdir Gouveia; Theodoro, Letícia Helena

doi:10.1016/j.pdpdt.2021.102265

Cited by 7 publications

(5 citation statements)

References 63 publications

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“…Relevant evidence exhibited that Cur can effectively prevent and treat oral diseases, such as oral mucositis (OM) (GRADE level: low) and chronic periodontitis (GRADE level: moderate) (Dharman et al, 2021; Guo et al, 2021; Souza et al, 2021; Terby et al, 2021; Yuan, 2019; Zhang, Tang, & Wei, 2021). However, the results of several studies failed to show a positive effect of oral disease (GRADE level: low) (Al‐Maweri et al, 2021; Oliveira et al, 2021; Zhang, Huang, et al, 2021).…”

Section: Resultsmentioning

confidence: 99%

Zingiberaceae plants/curcumin consumption and multiple health outcomes: An umbrella review of systematic reviews and meta‐analyses of randomized controlled trials in humans

Zhang

Deng

Tang

et al. 2022

Phytotherapy Research

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This umbrella review is to recapitulate and grade the available evidence of associations between consumption of Zingiberaceae plants/curcumin (Cur) and multiple health‐related outcomes. This study included 161 meta‐analyses of randomized controlled trials in 76 articles with 67 unique health outcomes. Data on heterogeneity and publication bias are considered to assess the quality of evidence. Based on the different impact of Zingiberaceae plants/Cur on human health, the advantages outweigh the disadvantages. Zingiberaceae plants/Cur can mainly improve metabolic syndrome, non‐alcoholic fatty liver disease, cardiovascular disease, and some chronic inflammatory diseases, likewise, obviously relief the pain of osteoarthritis and related diseases. Ginger supplements have been shown to improve vomiting during pregnancy and to relieve nausea and vomiting caused by chemotherapy and surgery. The surgery is any type of surgery, including laparoscopic surgery, gynecological surgery and mixed surgery. Beneficial associations were found with Cur intervention in gastrointestinal, neurological and oral diseases. Zingiberaceae plants/Cur are generally safe and favorable for multiple health outcomes in humans. High‐quality research is further needed to prove the observed associations.

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Section: Resultsmentioning

confidence: 99%

Zingiberaceae plants/curcumin consumption and multiple health outcomes: An umbrella review of systematic reviews and meta‐analyses of randomized controlled trials in humans

Zhang

Deng

Tang

et al. 2022

Phytotherapy Research

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“…Herpesviruses are frequent inhabitants of oral tissue. However, their presence and periodontal pathogenicity in the periodontitis lesions are still unclear [45]. Studies from the Slots lab established a new periodontal infectious agent, herpesviruses, which were consistently detected in inflamed gingival biopsies and GCF.…”

Section: Human Herpesviruses and Oral Inflammatory Diseasesmentioning

confidence: 99%

Herpesviruses and SARS-CoV-2: Viral Association with Oral Inflammatory Diseases

Banks,

Capistrano,

Brandini

et al. 2024

Pathogens

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The oral cavity is a niche for diverse microbes, including viruses. Members of the Herpesviridae family, comprised of dsDNA viruses, as well as severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), an ssRNA virus, are among the most prevalent viruses infecting the oral cavity, and they exhibit clinical manifestations unique to oral tissues. Viral infection of oral mucosal epithelia triggers an immune response that results in prolonged inflammation. The clinical and systemic disease manifestations of HHV have been researched extensively, and several recent studies have illuminated the relationship between HHV and oral inflammatory diseases. Burgeoning evidence suggests the oral manifestation of SARS-CoV-2 infection includes xerostomia, dysgeusia, periodontal disease, mucositis, and opportunistic viral and bacterial infections, collectively described as oral post-acute sequelae of COVID-19 (PASC). These diverse sequelae could be a result of intensified immune responses initially due to the copious production of proinflammatory cytokines: the so-called “cytokine storm syndrome”, facilitating widespread oral and non-oral tissue damage. This review explores the interplay between HHV, SARS-CoV-2, and oral inflammatory diseases such as periodontitis, endodontic disease, and peri-implantitis. Additionally, the review discusses proper diagnostic techniques for identifying viral infection and how viral diagnostics can lead to improved overall patient health.

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“…The leading clinical indicators of PDT-assisted SRP treatment are the reduction of periodontal probing depth (PPD) and the increased level of CAL, defined as the difference between PPD and CAL levels in the baseline and follow-up periods, respectively. 84,85 Soundarajan et al 86,87 showed that the additional PDT could significantly improve the indicators of PPD, CAL, as well as plaque index (PI), gingival index (GI), and gingival recession (REC) than SRP alone in patients with periodontitis. Grzech-Lesniak et al 88 showed that multiple applications of PDT significantly improved bleeding on probing (BOP) compared with SRP alone, which also can be seen among geriatric patients TA B L E 2 Antibacterial effects of PDT on periodontal pathogens in vivo.…”

Section: Clinical Effects Of the Pdt-assisted Srpmentioning

confidence: 99%

“…The leading clinical indicators of PDT‐assisted SRP treatment are the reduction of periodontal probing depth (PPD) and the increased level of CAL, defined as the difference between PPD and CAL levels in the baseline and follow‐up periods, respectively 84,85 . Soundarajan et al 86,87 .…”

Section: Clinical Effect Of Pdt In the Treatment Of Periodontitismentioning

confidence: 99%

Photodynamic therapy in periodontitis: A narrative review

Nie,

Zhang,

Pathak

et al. 2024

Photoderm Photoimm Photomed

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BackgroundPeriodontitis, a chronic infectious disease, is primarily caused by a dysbiotic microbiome, leading to the destruction of tooth‐supporting tissues and tooth loss. Photodynamic therapy (PDT), which combines excitation light with photosensitizers (PS) and oxygen to produce antibacterial reactive oxygen species, is emerging as a promising adjuvant treatment for periodontitis.MethodsThis review focuses on studies examining the antibacterial effects of PDT against periodontal pathogens. It also explores the impact of PDT on various aspects of periodontal health, including periodontal immune cells, human gingival fibroblasts, gingival collagen, inflammatory mediators, cytokines in the periodontium, vascular oxidative stress, vascular behavior, and alveolar bone health. Clinical trials assessing the types of PSs and light sources used in PDT, as well as its effects on clinical and immune factors in gingival sulcus fluid and the bacterial composition of dental plaque, are discussed.ResultsThe findings indicate that PDT is effective in reducing periodontal pathogens and improving markers of periodontal health. It has shown positive impacts on periodontal immune response, tissue integrity, and alveolar bone preservation. Clinical trials have demonstrated improvements in periodontal health and alterations in the microbial composition of dental plaque when PDT is used alongside conventional treatments.ConclusionsPDT offers a promising adjunctive treatment for periodontitis, with benefits in bacterial reduction, tissue healing, and immune modulation. This article highlights the potential of PDT in periodontal therapy and emphasizes the need for further research to refine its clinical application and efficacy.

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Adjuvant effects of curcumin as a photoantimicrobial or irrigant in the non-surgical treatment of periodontitis: Systematic review and meta-analysis

Cited by 7 publications

References 63 publications

Zingiberaceae plants/curcumin consumption and multiple health outcomes: An umbrella review of systematic reviews and meta‐analyses of randomized controlled trials in humans

Zingiberaceae plants/curcumin consumption and multiple health outcomes: An umbrella review of systematic reviews and meta‐analyses of randomized controlled trials in humans

Herpesviruses and SARS-CoV-2: Viral Association with Oral Inflammatory Diseases

Photodynamic therapy in periodontitis: A narrative review

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