Adjuvant therapy for gastric cancer: What have we learned since INT0116?

Jácome, Alexandre A. A.

doi:10.3748/wjg.v21.i13.3850

Cited by 15 publications

(9 citation statements)

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“…5-FU adjuvant therapy of GC significantly improves OS. 71 In this study, we found that high expression of CCNB1 predicted poor OS in GC patients who receive 5-FU-based chemotherapy treatment. Therefore, CCNB1 might be a potential therapy target for GC patients who receive 5-FU-based chemotherapy treatment.…”

Section: Discussionmentioning

confidence: 55%

Clinical significance and biological roles of cyclins in gastric cancer

Zhang¹,

Li²,

Wang³

et al. 2018

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Background and aimCyclins have been reported to be overexpressed with poor prognosis in several human cancers. However, limited numbers of studies evaluated the expressions and prognostic roles of cyclins in gastric cancer (GC). We aim to evaluate the expressions and prognostic roles of cyclins. Also, further efforts were made to explore biological function of the differentially expressed cyclins.MethodsCyclins expressions were analyzed by Oncomine and The Cancer Genome Atlas datasets, and the prognostic roles of cyclins in GC patients were investigated by the Kaplan–Meier Plotter database. Then, a comprehensive PubMed literature search was performed to identify expression and prognosis of cyclins in GC. Biological functions of the differentially expressed cyclins were explored through Enrich R platform, and KEGG and transcription factor were analyzed.ResultsThe expression levels of CCNA2 (cyclin A2), CCNB1 (cyclin B1), CCNB2 (cyclin B2), and CCNE1 (cyclin E1) mRNAs were identified to be significantly higher in GC tissues than in normal tissues in both Oncomine and The Cancer Genome Atlas datasets. High expressions of CCNA2, CCNB1, and CCNB2 mRNAs were identified to be related with poor overall survival in Kaplan–Meier Plotter dataset. Evidence from clinical studies showed that CCNB1 was related with overall survival in GC patients. Cyclins were associated with several biological pathways, including cell cycle, p53 signaling pathway, FoxO signaling pathway, viral carcinogenesis, and AMPK signaling pathway. Enrichment analysis also showed that cyclins interacted with some certain transcription factors, such as FOXM1, SIN3A, NFYA, and E2F4.ConclusionBased on our results, high expressions of cyclins were related with poor prognosis in GC patients. The above information might be useful for better understanding the clinical and biological roles of cyclins mRNA and guiding individualized treatments for GC patients.

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Section: Discussionmentioning

confidence: 55%

Clinical significance and biological roles of cyclins in gastric cancer

Zhang¹,

Li²,

Wang³

et al. 2018

OTT

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“…For patients at high risk of postoperative recurrence, adjuvant chemotherapy is recognized as the standard of care in the Far East . In our patient cohort, S‐1 monotherapy comprised the majority (90%) of treatment regimens for adjuvant therapy.…”

Section: Discussionmentioning

confidence: 99%

Pathological tumor infiltrative pattern and sites of initial recurrence in stage II/III gastric cancer: Propensity score matching analysis of a multi‐institutional dataset

et al. 2018

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BackgroundAdvanced gastric cancer frequently recurs even after radical resection followed by adjuvant chemotherapy. The aim of this study was to evaluate the relationship between pathological infiltrative pattern (INF) and initial recurrence patterns in patients with stage II/III gastric cancer using a large multicenter database.MethodsWe retrospectively analyzed 1098 eligible patients who underwent curative gastrectomy for stage II/III gastric cancer at nine institutions between 2010 and 2014. Patients were categorized into the INF‐a/b and INF‐c groups and adjusted using propensity score matching.ResultsAfter propensity score matching, 686 patients (343 for each) were classified in the INF‐a/b and INF‐c groups. There were no significant differences in overall and disease‐free survival between the two groups. In the INF‐a/b group, frequencies of recurrence at the peritoneum, lymph node, and liver were equivalent. In contrast, the peritoneum was the most frequent site and accounted for 60% of the total recurrences in the INF‐c group. The cumulative peritoneal recurrence rate was significantly higher in the INF‐c group than in the INF‐a/b group (hazard ratio 2.47). INF‐c was a significant risk factor for peritoneal recurrences in most subgroups including age, sex, macroscopic type, tumor differentiation, and disease stage, and whether the postoperative treatment was given. Multivariate analysis identified INF‐c as an independent risk factor for peritoneal recurrences. The cumulative liver recurrence rate was significantly higher in the INF‐a/b group than in the INF‐c group (hazard ratio 3.44).ConclusionsINF may represent an important predictor of recurrence patterns after curative resection of stage II/III gastric cancer.

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“…They recommended the use of perioperative chemotherapy for managing resectable gastric cancer. In another study Jácome [17], sought to examine the significance of the use of 5-fluorouracil in reducing cases of relapses and overall improvement in the adjuvant chemotherapy process. The study acknowledges that the use of 5-fluorouracil in the chemotherapy process has been adopted in the vast western region.…”

Section: Authormentioning

confidence: 99%

The Relative Efficacies and Developments in Adjuvant and Neoadjuvant Therapy for Gastric Cancer - Review

Ullah¹,

MohayUddin²,

Iqbal³

et al. 2016

J Gastrointest Dig Syst

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This present study examined the efficacy and developments in gastric cancer modalities. This is in light of the fact that gastric cancer accounts for a significant number of cancer related cases reported across the world. Moreover, it is contented that curative treatment is still poor because modalities have been studied, but they have all been yielding controversial results. The study establishes that all modalities are effective and this rule out the popular claims that they are infective. Surgery has been lauded to be the most effective modality for control of the malignant cells at their early stages of growth. It is unfortunate that most patients are diagnosed when the malignant cells are at the advanced stage; the late diagnosis results in high rates of relapses. With early strategies to improve the treatment modalities having failed, a series of studies have been undertaken and significant improvements have been realized. However, these approaches have some limitations. The improvement of outcomes in the deployment of these modalities rests upon future developments to address the underlying inadequacies. The strategies of gastric cancer management are so dynamic and are reflected by the ongoing studies on how to manage and contain the cancer menace.

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Adjuvant therapy for gastric cancer: What have we learned since INT0116?

Cited by 15 publications

References 50 publications

Clinical significance and biological roles of cyclins in gastric cancer

Clinical significance and biological roles of cyclins in gastric cancer

Pathological tumor infiltrative pattern and sites of initial recurrence in stage II/III gastric cancer: Propensity score matching analysis of a multi‐institutional dataset

The Relative Efficacies and Developments in Adjuvant and Neoadjuvant Therapy for Gastric Cancer - Review

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