Administration of B-group vitamins reduces circulating homocysteine in polycystic ovarian syndrome patients treated with metformin: a randomized trial

Kılıçdağ, Esra Bulgan; Bağış, Tayfun; Tarım, Ebru; Aslan, Erdoğan; Erkanli, Serkan; Şimşek, Erhan; Haydardedeoğlu, Bülent; Kuşçu, Esra

doi:10.1093/humrep/deh825

Cited by 68 publications

(66 citation statements)

References 61 publications

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“…Our study found no differences in the absolute level of serum vitamin B 12 and folate between women with PCOS and matched controls, but we found negative correlations between serum folate and fasting insulin, HbA 1c , and vitamin C levels (Table II). Our findings suggest that the role of vitamin B 12 and folate in the pathogenesis of PCOS is not yet clear.…”

Section: Discussioncontrasting

confidence: 52%

“…In conclusion, the serum levels of vitamins A, B 12 , C, and D and Zn may change in patients with PCOS. The findings in this study should be investigated with further trials in order to obtain new insights into PCOS.…”

Section: Discussionmentioning

confidence: 85%

“…It has been previously demonstrated that folate and vitamin B 12 treatment improved insulin resistance in patients with metabolic syndrome [12]. Kaya et al been reported that insulin resistance, obesity, and elevated homocysteine were associated with lower serum vitamin B 12 concentrations in PCOS patients [13].…”

Section: Discussionmentioning

confidence: 96%

“…That is, the same reason has to play a role in both the synthesis phase and the effect phase of insulin. There is increasing evidence that vitamin D affects insulin and glucose metabolism, and a low vitamin D status is suspected to be a risk factor for impaired glucose tolerance and insulin resistance [4], but there is no evidence to suggest that there is a relationship between vitamin A, vitamin B 12 , vitamin C, folate, zinc (Zn) and PCOS in the literature. In the current study, we examined whether a low vitamin A, vitamin B 12 , vitamin C, vitamin D, folate and zinc status can be observed in Turkish women with PCOS.…”

Section: Introductionmentioning

confidence: 99%

“…In the current study, we examined whether a low vitamin A, vitamin B 12 , vitamin C, vitamin D, folate and zinc status can be observed in Turkish women with PCOS. In addition, we investigated the relationship between serum vitamin A, vitamin B 12 , vitamin C, vitamin D, folate and zinc concentration and metabolic or clinical profiles of PCOS.…”

Section: Introductionmentioning

confidence: 99%

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Assessment of the relationship between serum vitamin (A, B12, C, D, folate) and zinc levels and polycystic ovary syndrome

Külhan¹,

Kulhan²,

Naykı³

et al. 2017

Arch Med Sci Civil Dis

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Introduction There is increasing evidence that vitamin D affects insulin and glucose metabolism, and a low vitamin D status is suspected to be a risk factor for impaired glucose tolerance, insulin resistance and so polycystic ovary syndrome (PCOS), but there is no evidence to suggest that there is a relationship between vitamin A, vitamin B12, vitamin C, folate, zinc (Zn) and PCOS in the literature. We aimed to investigate the levels of vitamins A, B12, C and D and zinc and the association between vitamins A, B12, C and D, folate and zinc level and hormonal-biochemical parameters in PCOS. Material and methods: We recruited 65 women with PCOS and 67 healthy individuals. Correlations between clinical and metabolic parameters and vitamins A, B12, C and D and zinc status were analyzed separately in patients and controls. Results: Women with PCOS showed a decreased serum level of vitamin A compared with the control group (p < 0.05), but they showed no differences in the levels of vitamin D, vitamin B12, vitamin C, folate or Zn (p > 0.05). Conclusions: Our study found no differences in the absolute levels of serum vitamins B12, C, D, folate or Zn between PCOS patients and matched controls, but the vitamin A level was lower in PCOS patients. Prevalence of vitamins A, B12, C and D and Zn insufficiency was equally common among both patients and controls.

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Section: Discussioncontrasting

confidence: 52%

Section: Discussionmentioning

confidence: 85%

Section: Discussionmentioning

confidence: 96%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Assessment of the relationship between serum vitamin (A, B12, C, D, folate) and zinc levels and polycystic ovary syndrome

Külhan¹,

Kulhan²,

Naykı³

et al. 2017

Arch Med Sci Civil Dis

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Antioxidants for female subfertility

Showell

Mackenzie‐Proctor

Jordan

et al. 2013

Cochrane Database of Systematic Reviews

118

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Antioxidants for female subfertility

Showell

Mackenzie‐Proctor

Jordan

et al. 2017

Cochrane Database of Systematic Reviews

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Background A couple may be considered to have fertility problems if they have been trying to conceive for over a year with no success. This may affect up to a quarter of all couples planning a child. It is estimated that for 40% to 50% of couples, subfertility may result from factors affecting women. Antioxidants are thought to reduce the oxidative stress brought on by these conditions. Currently, limited evidence suggests that antioxidants improve fertility, and trials have explored this area with varied results. This review assesses the evidence for the effectiveness of different antioxidants in female subfertility. Objectives To determine whether supplementary oral antioxidants compared with placebo, no treatment/standard treatment or another antioxidant improve fertility outcomes for subfertile women. Search methods We searched the following databases (from their inception to September 2016) with no language or date restriction: Cochrane Gynaecology and Fertility Group (CGFG) specialised register, the Cochrane Central Register of Studies (CENTRAL CRSO), MEDLINE, Embase, PsycINFO, CINAHL and AMED. We checked reference lists of appropriate studies and searched for ongoing trials in the clinical trials registers. Selection criteria We included randomised controlled trials (RCTs) that compared any type, dose or combination of oral antioxidant supplement with placebo, no treatment or treatment with another antioxidant, among women attending a reproductive clinic. We excluded trials comparing antioxidants with fertility drugs alone and trials that only included fertile women attending a fertility clinic because of male partner infertility. Data collection and analysis Two review authors independently selected eligible studies, extracted the data and assessed the risk of bias of the included studies. The primary review outcome was live birth; secondary outcomes included clinical pregnancy rates and adverse events. We pooled studies using a fixed-effect model, and calculated odds ratios (ORs) with 95% confidence intervals (CIs) for the dichotomous outcomes of live birth, clinical pregnancy and adverse events. We assessed the overall quality of the evidence by applying GRADE criteria.

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Administration of B-group vitamins reduces circulating homocysteine in polycystic ovarian syndrome patients treated with metformin: a randomized trial

Abstract: These findings suggest that B-group vitamins and folic acid administration counteract the Hcy-increasing effect seen with metformin therapy.

Cited by 68 publications

References 61 publications

Assessment of the relationship between serum vitamin (A, B<SUB>12</SUB>, C, D, folate) and zinc levels and polycystic ovary syndrome

Assessment of the relationship between serum vitamin (A, B<SUB>12</SUB>, C, D, folate) and zinc levels and polycystic ovary syndrome

Antioxidants for female subfertility

Antioxidants for female subfertility

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