Assessment of the relationship between serum vitamin (A, B&lt;SUB&gt;12&lt;/SUB&gt;, C, D, folate) and zinc levels and polycystic ovary syndrome

Külhan, Mehmet; Kulhan, Nur Gözde; Naykı, Ümit; Naykı, Cenk; Ata, Nahit; Ulug, Pasa; Mertoğlu, Cuma

doi:10.5114/amscd.2017.66840

Cited by 12 publications

(9 citation statements)

References 17 publications

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“…According to the literature, folate status in women is related to their age. Low dietary folate intake and low biochemical folate status have been found in younger women compared to women over 30 years of age [35–37]. The results of our study confirm that age is associated with folate status.…”

Section: Discussionsupporting

confidence: 87%

Evaluation of folate concentration in amniotic fluid and maternal and umbilical cord blood during labor

Suliburska

Kocyłowski

Grzesiak

et al. 2019

aoms

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IntroductionFolate is required for fetal, placental and maternal tissue growth during pregnancy. A decline in maternal circulating folate concentrations and an increase in total homocysteine (a non-specific indicator of folate deficiency) have been observed with the progression of pregnancy. However, the role of folate in the third trimester of pregnancy is not clear and folate status in late pregnancy has not so far been widely analyzed. The main aim of this retrospective cross-sectional study was to determine the folate concentrations in amniotic fluid and in maternal and umbilical cord blood serum derived during delivery.Material and methodsThis study was conducted on 175 pregnant Polish women (white/Caucasian) aged between 17 and 42 years. Only pregnancies without birth defects were included in this study. Amniotic fluid, maternal serum, and umbilical cord blood samples were collected during vaginal delivery or cesarean section. Folate concentration was determined using a microbiological assay.ResultsStrong correlations were observed between the concentrations of folate in amniotic fluid and maternal serum (rho = 0.67, p < 0.001) and amniotic fluid and cord blood serum (rho = 0.49, p < 0.001) and between maternal serum and cord blood serum (rho = 0.67, p < 0.001). Folate concentrations in amniotic fluid were significantly associated with maternal age (rho = 0.19, p < 0.05). Pre-pregnancy body mass index and maternal weight/neonatal birth weight ratio were independent predictors of folate concentrations in maternal serum (β = 0.33, p < 0.05; β = –0.19, p < 0.05) and amniotic fluid (β = 0.28, p < 0.05; β = –0.19, p < 0.05) in late pregnancy.ConclusionsFolate concentrations in amniotic fluid are associated with maternal and neonatal folate status peripartum in healthy women.

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Section: Discussionsupporting

confidence: 87%

Evaluation of folate concentration in amniotic fluid and maternal and umbilical cord blood during labor

Suliburska

Kocyłowski

Grzesiak

et al. 2019

aoms

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“…Polycystic ovary syndrome (PCOS) is one of the most common endocrine disorders in women of reproductive age. Although the exact causes of PCOS are poorly understood, it is generally believed that the genetic background [ 1 ] exacerbated by lifestyle and environmental factors [ 2 , 3 ] may indicate an individual’s predisposition to the development of this disorder. PCOS predominantly affects overweight/obese women and is frequently associated with metabolic syndrome and increased risk for infertility, cardiovascular disease, and endometrial cancer [ 4 ].…”

Section: Introductionmentioning

confidence: 99%

National and regional trends in the prevalence of polycystic ovary syndrome since 1990 within Europe: the modeled estimates from the Global Burden of Disease Study 2016

Miazgowski

Martopullo

Widecka³

et al. 2021

Arch Med Sci

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Introduction: The exact prevalence of polycystic ovary syndrome (PCOS) is difficult to assess due to the clinical heterogeneity of this condition, the lack of a universal definition as well as the lack of studies comparing differences within and between ethnic groups across geographical regions. Material and methods: Using a modeling approach, we analyzed the data from Global Burden of Disease Study 2016 and extracted the national and regional estimates on PCOS prevalence since 1990 in females aged 15-49 years by country and three major European regions: Western, Central, and Eastern. Results: The average prevalence of PCOS in Europe was 276.4 cases per 100,000 (95% uncertainty interval (UI): 207.8-363.2). The estimates varied markedly across countries and regions, with the highest rates per 100,000 in the Czech Republic (460.6) and the lowest in Sweden (34.10); other Nordic countries, Germany, and the UK had relatively low rates as well. The rates in Central and Eastern Europe were more than three times higher than those in Western countries. They were comparable among Eastern countries, ranging from 406.4 in Lithuania to 443.1 in Russia. Within Central Europe, PCOS prevalence was lowest in Turkey and Albania, while in the majority of the remaining countries, the prevalence ranged between 420 and 440 per 100,000. Between 1990 and 2016, the rates across European regions were relatively stable. Conclusions: We found highly variable national and regional prevalence of PCOS among European females. Our estimates encourage the search at the population level for new environmental and genetic determinants of PCOS.

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“…However, no association has been found between hirsutism and serum zinc concentration. Changes in LH, FSH and prolactin concentrations were also associated with hormonal imbalances among women with PCOS, although the direction of these changes was not so obvious [ 27 , 46 , 47 , 48 , 50 ] and in some studies statistically insignificant [ 28 , 46 , 47 , 48 , 49 , 50 ], also following supplementation with zinc sulfate [ 54 ].…”

Section: Resultsmentioning

confidence: 99%

“…Among the presented studies in Table 2 different biomarkers were used to establish glucose tolerance and insulin resistance. Studies documented increases in HOMA-IR, HOMA2-IR (homeostasis model assessment-insulin resistance index), and also in concentration of insulin, fasting insulin, glucose and fasting glucose [18,27,46,48,49], but decreases in GIR (glucose/insulin ratio) and QUICKI (quantitative insulin sensitivity check index) [18,27]. It was noted that zinc supplementation (Table 3) seems to be beneficial for patients with PCOS, because it was observed to significantly decrease both insulin concentration and HOMA-IR index [52,53].…”

Section: Zinc and Polycystic Ovary Syndrome (Pcos)mentioning

confidence: 99%

The Role of Zinc in Selected Female Reproductive System Disorders

et al. 2020

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Zinc is an essential microelement that plays many important functions in the body. It is crucial for the regulation of cell growth, hormone release, immunological response and reproduction. This review focuses on its importance in the reproductive system of women of reproductive and postmenopausal ages, not including its well described role in pregnancy. Only recently, attention has been drawn to the potential role of zinc in polycystic ovary syndrome (PCOS), dysmenorrhea, or endometriosis. This review is mainly based on 36 randomized, controlled studies on reproductive, pre- and post-menopausal populations of women and on research trying to explain the potential impact of zinc and its supplementation in the etiology of selected female reproductive system disorders. In women with PCOS, zinc supplementation has a positive effect on many parameters, especially those related to insulin resistance and lipid balance. In primary dysmenorrhea, zinc supplementation before and during each menstrual cycle seems to be an important factor reducing the intensity of menstrual pain. On the other hand, little is known of the role of zinc in endometriosis and in postmenopausal women. Therefore, further studies explaining the potential impact of zinc and its supplementation on female reproductive system would be highly advisable and valuable.

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Assessment of the relationship between serum vitamin (A, B<SUB>12</SUB>, C, D, folate) and zinc levels and polycystic ovary syndrome

Cited by 12 publications

References 17 publications

Evaluation of folate concentration in amniotic fluid and maternal and umbilical cord blood during labor

Evaluation of folate concentration in amniotic fluid and maternal and umbilical cord blood during labor

National and regional trends in the prevalence of polycystic ovary syndrome since 1990 within Europe: the modeled estimates from the Global Burden of Disease Study 2016

The Role of Zinc in Selected Female Reproductive System Disorders

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