Administration of Biological Products

Prittie, Jennifer

doi:10.1002/9781118997246.ch59

Cited by 3 publications

(2 citation statements)

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“…In some animals, a defining event triggering transfusion such as severe blood loss was present, although not all animals with identifiable major blood loss received a transfusion. The decision to administer a transfusion was based on clinical assessment . Disturbances of sufficient oxygen delivery to the tissues from hypotension, respiratory dysfunction related to volume overload or pulmonary hemorrhage, or anemia are common with during hemodialysis.…”

Section: Discussionmentioning

confidence: 99%

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Blood Transfusions in Dogs and Cats Receiving Hemodialysis: 230 Cases (June 1997–September 2012)

Langston

Cook

Eatroff

et al. 2017

Veterinary Internal Medicne

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BackgroundMultiple factors exist that contribute to anemia in dogs and cats receiving hemodialysis, can necessitate transfusion.ObjectivesTo describe blood product usage in dogs and cats with acute and chronic kidney disease that were treated with intermittent hemodialysis to determine risk factors associated with the requirement for blood product transfusion.Animals83 cats and 147 dogs undergoing renal replacement therapy at the Animal Medical Center for acute or chronic kidney disease.MethodsRetrospective medical record review of all dogs and cats receiving renal replacement therapy for kidney disease, from June 1997 through September 2012.ResultsBlood products (whole blood, packed RBCs, or stromal‐free hemoglobin) were administered to 87% of cats and 32% of dogs. The number of dialysis treatments was associated with the requirement for transfusion in cats (adjusted OR 2.21, 95% CI 1.13, 4.32), but not in dogs (adjusted OR 0.98, 95% CI 0.95, 1.03). Administration of a blood product was associated with a higher likelihood of death in dogs (OR 3.198, 95% CI 1.352, 7.565; P = .0098), but not in cats (OR 1.527, 95% CI 0.5404, 4.317, P = .2).Conclusions and Clinical ImportanceVeterinary hospitals with a hemodialysis unit should have reliable and rapid access to safe blood products in order to meet the needs of dogs and cats receiving dialysis.

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Section: Discussionmentioning

confidence: 99%

“…One unit of feline WB was estimated at 60 mL, while ½ unit of feline WB was estimated at 30 mL. To calculate the total amount of blood product used, we considered each ml of WB or HBOC to be equal to 0.5 mL pRBC …”

Section: Methodsmentioning

confidence: 99%