Administration of coenzyme Q10 to a diabetic rat model: changes in biochemical, antioxidant, and histopathological indicators

Peter, Jerine S.; M, Shalini; Giridharan, R.; Basha, K Sathik; Lavinya, Udhaya B.; Sabina, Evan Prince

doi:10.1007/s13410-019-00752-z

Cited by 3 publications

(1 citation statement)

References 38 publications

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“…CoQ10 intake by DM patients on hemodialysis for 12 weeks was associated with increases in TAS and NO levels and decreases in the levels of highly sensitive CRP, but it did not have any positive effects on MDA or GSH levels [165]. CoQ10 has been shown to normalize biochemical and antioxidant parameters, as well as histopathological characteristics, in experimental rats [166]. Combined CoQ10 and metformin therapy improved endothelial dysfunction and inflammatory changes in patients with T2DM, along with improvements in metabolic profiles [167].…”

Section: Coenzyme Q10mentioning

confidence: 99%

Diabetic Nephropathy: Significance of Determining Oxidative Stress and Opportunities for Antioxidant Therapies

Darenskaya

Kolesnikov

Semenova

et al. 2023

IJMS

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Diabetes mellitus (DM) belongs to the category of socially significant diseases with epidemic rates of increases in prevalence. Diabetic nephropathy (DN) is a specific kind of kidney damage that occurs in 40% of patients with DM and is considered a serious complication of DM. Most modern methods for treatments aimed at slowing down the progression of DN have side effects and do not produce unambiguous positive results in the long term. This fact has encouraged researchers to search for additional or alternative treatment methods. Hyperglycemia has a negative effect on renal structures due to a number of factors, including the activation of the polyol and hexosamine glucose metabolism pathways, the activation of the renin–angiotensin–aldosterone and sympathetic nervous systems, the accumulation of advanced glycation end products and increases in the insulin resistance and endothelial dysfunction of tissues. The above mechanisms cause the development of oxidative stress (OS) reactions and mitochondrial dysfunction, which in turn contribute to the development and progression of DN. Modern antioxidant therapies for DN involve various phytochemicals (food antioxidants, resveratrol, curcumin, alpha-lipoic acid preparations, etc.), which are widely used not only for the treatment of diabetes but also other systemic diseases. It has also been suggested that therapeutic approaches that target the source of reactive oxygen species in DN may have certain advantages in terms of nephroprotection from OS. This review describes the significance of studies on OS biomarkers in the pathogenesis of DN and analyzes various approaches to reducing the intensity of OS in the prevention and treatment of DN.

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Section: Coenzyme Q10mentioning

confidence: 99%

Diabetic Nephropathy: Significance of Determining Oxidative Stress and Opportunities for Antioxidant Therapies

Darenskaya

Kolesnikov

Semenova

et al. 2023

IJMS

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D-Galaktoz ile İndüklenen Farelerde Yaşlanma Modelinin Nefropatisi Üzerine Mirisitrin ve Vitamin E’nin Koruyucu Etkileri

Radmehr

Ahangarpour

Khorsandi

et al. 2021

Düzce Tıp Fakültesi Dergisi

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Aim: Aging occurs in cells and tissues due to oxidative stress in physiological conditions. D-galactose (DG) is widely used to cause aging in animal studies. In this study, the renal protective effects of myricitrin and vitamin E in the aging mice model induced by DG was evaluated. Material and Methods: Subcutaneous DG injection was used for induction of the aging model. 72 female mice were randomly divided into six groups: All groups were received DG at 500 mg/kg/d for six weeks. In the last 28 days, the groups treated with myricitrin subcutaneously received 5, 10, and 20 mg/kg/d, and the vitamin E group received 100 mg/kg/d by gavage. Urine and plasma albumin, BUN, creatinine levels, MDA, TAC, and kidney histological changes were evaluated. Results: Plasma albumin was significantly decreased (p=0.001), but a significant increase in urine albumin (p=0.001), BUN (p<0.001), and creatinine (p=0.010) levels was observed in the DG group when compared with the control. Also, a significant increase in MDA levels (p=0.002) along with a significant decrease in TAC (p=0.012) was observed. Histopathological changes such as congestion of erythrocytes (p<0.001), infiltration of inflammatory cells (p<0.001), and proximal tubule cell damage (p=0.004) significantly increased, while glomerulus diameter significantly decreased (p=0.038) in comparison to the control. Administration of myricitrin and vitamin E showed a significant ameliorative effect on all studied variables. Conclusion:The improvement effects of myricitrin on DG-induced kidney damage was approximately equivalent to vitamin E. Myricitrin and vitamin E could have beneficial effects on the nephropathy of aging model.

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Comparative Study on Antidiabetic Effects of Coenzyme Q10 and Quercetin on Streptozotocin-Induced Hyperglycemia in Rats

Bakr

2021

مجلة الاقتصاد المنزلی

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As estimated by Federation Diabetes Atlas, the number of diabetic patients will reach globally 592 million in 2035. Diabetes mellitus is a metabolic disorder characterized by hyperglycemia resulting from deficiency of insulin, its resistance or both. This investigation aimed to explore comparinor the antidiabetic effect of coenzyme Q10 and quercetin on streptozotocininduced hyperglycemia in rats. A sum of 24 adult male Albino rats weighing 200±5g each were used and were divided into 4 groups (n= 6 rats). One group kept as (C -ve) and fed on basal diet all over the experimental period (28 days), while the other groups were intraperitoneal injected with streptozotocin (STZ) at a dose of 40 mg/kg once a week for two weeks. One of the diabetic groups was fed basal diet only (C +ve) and the other two diabetic groups were fed on Coenzyme Q10 and Quercetin at a dose of 100mg/kg body weight (b. wt.) each. At the end of the trial, rats were mercy sacrificed and the blood and organs were removed then serum glucose,

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Administration of coenzyme Q10 to a diabetic rat model: changes in biochemical, antioxidant, and histopathological indicators

Cited by 3 publications

References 38 publications

Diabetic Nephropathy: Significance of Determining Oxidative Stress and Opportunities for Antioxidant Therapies

Diabetic Nephropathy: Significance of Determining Oxidative Stress and Opportunities for Antioxidant Therapies

D-Galaktoz ile İndüklenen Farelerde Yaşlanma Modelinin Nefropatisi Üzerine Mirisitrin ve Vitamin E’nin Koruyucu Etkileri

Comparative Study on Antidiabetic Effects of Coenzyme Q10 and Quercetin on Streptozotocin-Induced Hyperglycemia in Rats

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