Administration of Metoclopramide for Prevention of Nausea and Vomiting During Epidural Anesthesia for Elective Cesarean Section

Intraoperative nausea and vomiting during cesarean section under regional anesthesia

“…6 The overall incidence of IONV during regional anesthesia for cesarean section is extremely variable, up to 80%, depending on the anesthetic technique used (spinal, epidural or combined spinal-epidural) and on the preventive and therapeutic measures taken (Table 1). [7][8][9][10][11][12][13][14][15] The incidence of IONV may also vary significantly according to the stages of the surgical procedure (e.g. pre-delivery vs. post-delivery), different factors being implicated in the etiology.…”

Effect of flurbiprofen, metoclopramide and droperidol for nausea and emesis during cesarean section under spinal anesthesia

“…Flurbiprofen was significantly more effective in improving nausea and emesis than metoclopramide after 5 min (p \ 0.05). Effects on nausea and emesis did not significantly differ between flurbiprofen and droperidol, and between metoclopramide and droperidol measures applied [1][2][3][4][5][6][7][8][9][10][11]. Emetic symptoms have a complex and multifactorial etiology and can be influenced by age, gender, pain, operative procedure and anesthetic technique.…”

“…In our study, we focused on the antiemetic effects of flurbiprofen, metoclopramide and droperidol during cesarean section, and these agents were administered following the appearance of emetic symptoms. The dose of metoclopramide applied herein was based on a clinical investigation by Chestnut et al [3] who reported that 0.15 mg/kg of metoclopramide administered after cord clamping during cesarean section under epidural anesthesia reduced the incidence of intraoperative nausea from 36 to 12% and emesis from 15 to 0%. Lussos et al [2] reported significant reductions in the incidence of intraoperative nausea from 81 to 14% and emesis from 43 to 5% when 10 mg of metoclopramide was administered before spinal anesthesia was initiated for cesarean section.…”

“…Nausea and emesis during regional anesthesia for elective cesarean delivery is widespread, with a reported occurrence of 17-80% of patients experiencing a nausea and/or emesis event [1][2][3][4][5][6][7][8][9][10][11]. Metoclopramide and droperidol are commonly administered to reduce nausea and emesis in patients undergoing spinal anesthesia for cesarean section [1][2][3]12].…”

“…Metoclopramide and droperidol are commonly administered to reduce nausea and emesis in patients undergoing spinal anesthesia for cesarean section [1][2][3]12]. Intraoperative nausea and emesis occur more often among patients taking opioid analgesics than among those taking nonsteroidal anti-inflammatory drugs (NSAIDs) [13].…”