Adrenal Neoplasms in Children

Abramson, Sara J.

doi:10.1016/s0033-8389(22)00733-3

Cited by 43 publications

(1 citation statement)

References 127 publications

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“…Neuroblastoma is a medullary adrenal neoplasm as well as ganglioneuroblastoma and ganglioneuroma both of them arising from the primitive neural crest cells [1]. It is the most common extracranial solid tumor of childhood, accounting for 8-10% of all cancers in children [2][3][4]. Two thirds of neuroblastomas develop in the abdomen and of those, from two thirds up to 90% originates from the adrenals [1,5].…”

Section: Introductionmentioning

confidence: 99%

The Role of Fetal MRI and US in the Prenatal Diagnosis of Mixed Adrenal Neuroblastoma: A Case Report and Brief Literature Review

2021

Ann Case Report

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Neuroblastoma is a malignant tumor which develops from the neural crest cells of the sympathetic nervous system. Neuroblastoma represents 8-10% of all childhood neoplasms making it the most common extracranial solid tumor in childhood. It is sometimes occasionally detected prenatally during second and third trimester screening. Cross-sectional imaging is needed not only for assessment of the origin, extent of the tumor, local invasion, vascularity and calcifications, but also for staging of neuroblastoma, presence of lymphadenopathy and metastatic spread. Prenatal ultrasound (US) is first-line modality in evaluating neuroblastomas followed by fetal magnetic resonance imaging (MRI) for precise determination the extend of the tumor within the abdominal cavity or the retroperitoneal space. This report aims to present the role of fetal MRI as a valuable adjunct to US in a case of prenatally detected neuroblastoma, which is an important issue for prognostic counseling. Furthermore, beside this case study we would like to contribute a brief review of the literature.

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Section: Introductionmentioning

confidence: 99%

The Role of Fetal MRI and US in the Prenatal Diagnosis of Mixed Adrenal Neuroblastoma: A Case Report and Brief Literature Review

2021

Ann Case Report

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A possible case of renal osteodystrophy in a skeleton from medieval Wharram Percy, England

Mays

Turner‐Walker

2007

Intl J of Osteoarchaeology

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The skeletal remains of a child aged 13-15 years, recovered from Wharram Percy, England, and dating from AD 960-1700, were examined using gross observation, radiography and scanning electron microscopy. Lesions suggestive of renal osteodystrophy were found. Palaeopathological recognition of renal disease has hitherto relied upon the identification of soft tissue lesions or the presence of urinary calculi. This appears to be the first palaeopathological identification of renal insufficiency on the basis of skeletal changes alone.

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Three-Dimensional Segmentation of the Tumor in Computed Tomographic Images of Neuroblastoma

et al. 2006

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Segmentation of the tumor in neuroblastoma is complicated by the fact that the mass is almost always heterogeneous in nature; furthermore, viable tumor, necrosis, and normal tissue are often intermixed. Tumor definition and diagnosis require the analysis of the spatial distribution and Hounsfield unit (HU) values of voxels in computed tomography (CT) images, coupled with a knowledge of normal anatomy. Segmentation and analysis of the tissue composition of the tumor can assist in quantitative assessment of the response to therapy and in the planning of delayed surgery for resection of the tumor. We propose methods to achieve 3-dimensional segmentation of the neuroblastic tumor. In our scheme, some of the normal structures expected in abdominal CT images are delineated and removed from further consideration; the remaining parts of the image volume are then examined for the tumor mass. Mathematical morphology, fuzzy connectivity, and other image processing tools are deployed for this purpose. Expert knowledge provided by a radiologist in the form of the expected structures and their shapes, HU values, and radiological characteristics are incorporated into the segmentation algorithm. In this preliminary study, the methods were tested with 10 CT exams of four cases from the Alberta Children's Hospital. False-negative error rates of less than 12% were obtained in eight of the 10 exams; however, seven of the exams had falsepositive error rates of more than 20% with respect to manual segmentation of the tumor by a radiologist.

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Adrenal Neoplasms in Children

Cited by 43 publications

References 127 publications

The Role of Fetal MRI and US in the Prenatal Diagnosis of Mixed Adrenal Neuroblastoma: A Case Report and Brief Literature Review

The Role of Fetal MRI and US in the Prenatal Diagnosis of Mixed Adrenal Neuroblastoma: A Case Report and Brief Literature Review

A possible case of renal osteodystrophy in a skeleton from medieval Wharram Percy, England

Three-Dimensional Segmentation of the Tumor in Computed Tomographic Images of Neuroblastoma

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