2007
DOI: 10.1529/biophysj.106.088799
|View full text |Cite
|
Sign up to set email alerts
|

Adsorption, Lubrication, and Wear of Lubricin on Model Surfaces: Polymer Brush-Like Behavior of a Glycoprotein

Abstract: Using a surface force apparatus, we have measured the normal and friction forces between layers of the human glycoprotein lubricin, the major boundary lubricant in articular joints, adsorbed from buffered saline solution on various hydrophilic and hydrophobic surfaces: i), negatively charged mica, ii), positively charged poly-lysine and aminothiol, and iii), hydrophobic alkanethiol monolayers. On all these surfaces lubricin forms dense adsorbed layers of thickness 60-100 nm. The normal force between two surfac… Show more

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...
1
1

Citation Types

35
428
6

Year Published

2009
2009
2020
2020

Publication Types

Select...
6
3

Relationship

2
7

Authors

Journals

citations
Cited by 297 publications
(470 citation statements)
references
References 57 publications
35
428
6
Order By: Relevance
“…Mucins, and other well-hydrated molecules such as zwitterionic polymers, polysaccharides, and polyelectrolytes are generally good boundary lubricants when adsorbed [ 13,14 ] or assembled in brush structures [15][16][17][18] on surfaces. Hence, mucin-associated glycans could also be essential for the lubricative function of mucus.…”
Section: Doi: 101002/admi201500308mentioning
confidence: 99%
See 1 more Smart Citation
“…Mucins, and other well-hydrated molecules such as zwitterionic polymers, polysaccharides, and polyelectrolytes are generally good boundary lubricants when adsorbed [ 13,14 ] or assembled in brush structures [15][16][17][18] on surfaces. Hence, mucin-associated glycans could also be essential for the lubricative function of mucus.…”
Section: Doi: 101002/admi201500308mentioning
confidence: 99%
“…Differences in the amount and composition of glycans from mucins extracted from pig stomachs and mucins from bovine submaxillary glands correlate with their capacity to adsorb water. [ 12 ] However, other properties such as protein composition also differ between these two mucin species, precluding the establishment of a defi nitive link between the presence of mucin glycans and hydration.Mucins, and other well-hydrated molecules such as zwitterionic polymers, polysaccharides, and polyelectrolytes are generally good boundary lubricants when adsorbed [ 13,14 ] or assembled in brush structures [15][16][17][18] on surfaces. Hence, mucin-associated glycans could also be essential for the lubricative function of mucus.…”
mentioning
confidence: 99%
“…Boundary lubrication dominates during periods of high load and low velocity, when the lubricant film layer is thinner than the surface roughness (16). In healthy articular joints, a layer of lubricin molecules covers the surface of cartilage and acts as an antiadhesive and boundary lubricant to prevent cartilage damage as surface asperities move against each other (17)(18)(19)(20). Patients with the autosomal recessive disease camptodactyly-arthropathy-coxa vara-pericarditis syndrome (CACP) lack functional lubricin and develop precocious cartilage failure.…”
mentioning
confidence: 99%
“…For example, during normal walking, fluid film lubrication mechanisms such as soft-EHL and/or micro-EHL play major roles to maintain low friction and minimize wear. In contrast, in thin film conditions such as at slow motion or at movement after standing for a long time, it is expected that adsorbed films [9][10][11][12], surface gel films [13], hydration lubrication [14] and polymeric brush-like layers [15,16] contribute to keep friction low and protect rubbing surfaces.…”
Section: Introductionmentioning
confidence: 99%