Adult Hippocampal Neurogenesis Is Regulated by the Microbiome

Ogbonnaya, Ebere S.; Clarke, Gerard; Shanahan, Fergus; Dinan, Timothy G.; Cryan, John F.; O’Leary, Olivia F.

doi:10.1016/j.biopsych.2014.12.023

Cited by 400 publications

(281 citation statements)

References 14 publications

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“…Briefly, they extend to behaviours relevant to mood, cognition, pain and social interaction (Stilling et al, 2014, Burokas et al, 2015. More recently, studies have elaborated on this influence to describe a role for the gut microbiome in controlling neurogenesis, the integrity of the blood brain barrier and even maturation and activation of CNS microglia (Braniste et al, 2014, Erny et al, 2015, Ogbonnaya et al, 2015. This is in addition to the regulation of serotonin synthesis both in the CNS and ENS , Erny et al, 2015, Ridaura and Belkaid, 2015.…”

Section: Postnatal Implications Of the Microbiome On Brain Developmentmentioning

confidence: 97%

Early-life adversity and brain development: Is the microbiome a missing piece of the puzzle?

et al. 2017

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Section: Postnatal Implications Of the Microbiome On Brain Developmentmentioning

confidence: 97%

Early-life adversity and brain development: Is the microbiome a missing piece of the puzzle?

et al. 2017

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“…Studies demonstrating that the gut microbiota can influence cognitive function, anxiety and depressive-like behaviour in animals should be appreciated in the context that adult hippocampal neurogenesis is under microbial influence (Möhle et al, 2016;Ogbonnaya et al, 2015). However, it is not yet apparent whether this has any consequences for discrete populations of neurons that provide the interface between endogenous kynurenine pathway neuroactives and glutamatergic, and cholinergic neurotransmission.…”

Section: Microbial Regulation Of Cns Receptors Neurogenesis and Myelmentioning

confidence: 99%

Kynurenine pathway metabolism and the microbiota-gut-brain axis

et al. 2017

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“…A recent addition to this literature is the emerging role of the microbiome and the possibility of microbiota-brain interactions being active in depression [10,11] . The microbiota-gut-brain axis, which includes both commensal and pathogenic bacteria in the gut, may influence behaviour in several ways, including but not limited to putative interactions with the vagus nerve, changes in central nervous system functioning, the enteric nervous system, brain plasticity [12] , and the immune system [13,14] . In addition, experimental data indicate that the gut microbiota regulates blood-brain barrier permeability throughout life [15] .The composition of microbiota in the intestine influences barrier integrity and an increase in gut permeability (also referred to as the 'leaky gut') and its role in the translocation of bacteria (and their products) into tissue [16] ; this process has been implicated in the pathophysiology of MDD.…”

Section: Introductionmentioning

confidence: 99%

Gut Microbiota, Bacterial Translocation, and Interactions with Diet: Pathophysiological Links between Major Depressive Disorder and Non-Communicable Medical Comorbidities

Slyepchenko

Maes

Jacka

et al. 2016

Psychother Psychosom

220

136

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Background: Persistent low-grade immune-inflammatory processes, oxidative and nitrosative stress (O&NS), and hypothalamic-pituitary-adrenal axis activation are integral to the pathophysiology of major depressive disorder (MDD). The microbiome, intestinal compositional changes, and resultant bacterial translocation add a new element to the bidirectional interactions of the gut-brain axis; new evidence implicates these pathways in the patho-aetiology of MDD. In addition, abnormalities in the gut-brain axis are associated with several chronic non-communicable disorders, which frequently co-occur in individuals with MDD, including but not limited to irritable bowel syndrome (IBS), chronic fatigue syndrome (CFS), obesity, and type 2 diabetes mellitus (T2DM). Methods: We searched the PubMed/MEDLINE database up until May 1, 2016 for studies which investigated intestinal dysbiosis and bacterial translocation (the ‘leaky gut') in the pathophysiology of MDD and co-occurring somatic comorbidities with an emphasis on IBS, CFS, obesity, and T2DM. Results: The composition of the gut microbiota is influenced by several genetic and environmental factors (e.g. diet). Several lines of evidence indicate that gut-microbiota-diet interactions play a significant pathophysiological role in MDD and related medical comorbidities. Gut dysbiosis and the leaky gut may influence several pathways implicated in the biology of MDD, including but not limited to immune activation, O&NS, and neuroplasticity cascades. However, methodological inconsistencies and limitations limit comparisons across studies. Conclusions: Intestinal dysbiosis and the leaky gut may constitute a key pathophysiological link between MDD and its medical comorbidities. This emerging literature opens relevant preventative and therapeutic perspectives.

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Adult Hippocampal Neurogenesis Is Regulated by the Microbiome

Cited by 400 publications

References 14 publications

Early-life adversity and brain development: Is the microbiome a missing piece of the puzzle?

Early-life adversity and brain development: Is the microbiome a missing piece of the puzzle?

Kynurenine pathway metabolism and the microbiota-gut-brain axis

Gut Microbiota, Bacterial Translocation, and Interactions with Diet: Pathophysiological Links between Major Depressive Disorder and Non-Communicable Medical Comorbidities

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