Objective. To explore the application of professional whole-process case management during nursing in patients with triple-negative breast cancer. Methods. This study recruited 60 patients with triple-negative breast cancer who were diagnosed and treated at Department of Breast Surgery in our hospital assessed for eligibility between June 2018 and June 2020, and we assigned them at a ratio of 1 : 1 via the random number table method to receive either general nursing (control group) or professional whole-process case management plus general nursing (observation group). We analyzed and evaluated the hospitalization, the indwelling time of drainage tube, complications, recovery, quality of life, posttraumatic growth, and nursing satisfaction between these two groups at registration, discharge, and the sixth month after surgery, respectively. Results. Professional whole-process case management achieved a shorter duration of drainage tube placement and hospitalization and a lower incidence of postoperative complications versus general nursing (
P
<
0.05
). Moreover, the observation group had got better recovery (
P
<
0.05
) and a better quality of life at discharge and 6 months after surgery (
P
<
0.05
). Professional whole-process case management obtained higher scores of posttraumatic growth and higher nursing satisfaction versus general nursing (
P
<
0.05
). Conclusion. Whole-process case management promotes the postoperative recovery of patients with triple-negative breast cancer and shortens the duration of drainage tube indwelling and hospitalization, which lowers the incidence of postoperative complications, improves their quality of life, and enhances nursing satisfaction.