Advanced Glycation End Products (AGEs) Induce Apoptosis via a Novel Pathway

Mahali, Sidhartha; Raviprakash, Nune; Raghavendra, Pongali B.; Manna, Sunil K.

doi:10.1074/jbc.m111.279190

Cited by 65 publications

(55 citation statements)

References 43 publications

(41 reference statements)

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“…NF-κB in unstimulated cells remains sequestered in the cytoplasm by IκB. Upon stimulation, IκB undergoes phosphorylation and gradually degrades, and NF-κB becomes free and translocated into the nucleus (28).…”

Section: Longistatin Prevents Nf-κb Translocationmentioning

confidence: 99%

Longistatin in tick saliva blocks advanced glycation end-product receptor activation

Anisuzzaman¹,

Hatta²,

Miyoshi³

et al. 2014

J. Clin. Invest.

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Section: Longistatin Prevents Nf-κb Translocationmentioning

confidence: 99%

Longistatin in tick saliva blocks advanced glycation end-product receptor activation

Anisuzzaman¹,

Hatta²,

Miyoshi³

et al. 2014

J. Clin. Invest.

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“…55 In vitro DNA binding assays were performed with HeLa cells which were cultured in 60 mm petri dishes overnight and stimulated with 1 nM of tumour necrosis factor (TNF) for 1 h.…”

Section: Experimental Protocols For Mtt Ldh and Dna Binding Assaysmentioning

confidence: 99%

Synthesis and characterization of some water soluble Zn(ii) complexes with (E)-N-(pyridin-2-ylmethylene)arylamines that regulate tumour cell death by interacting with DNA

et al. 2014

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The synthesis and spectroscopic properties of nine water soluble zinc(II) complexes of (E)-N-(pyridin-2-ylmethylene)arylamines (Ln) with the general formula [Zn(X)2(Ln)] (X = Cl−, Br−, I−; (1-8)) and [Zn(-N3)-(N3)(L3)]2 (9) are reported. The complexes were characterized by elemental analysis and their spectroscopic properties were studied using UV-Visible, fluorescence, IR and 1H NMR spectroscopies. The solid state structures of zinc(II) complexes 2-4 and 6-9 were established by single crystal X-ray crystallography. The majority of the structures are mononuclear with tetra-coordinate zinc centres (2-4, 6 and 7) except where L carries an additional donor atom capable of coordinating zinc (8), in which case the zinc atom has a distorted square pyramidal geometry. The centrosymmetric molecule of [Zn(-N3)(N3)(L3)]2 (9) is binuclear with the zinc atoms in a trigonal bipyramidal coordination environment. In general, the dichlorozinc derivatives 1, 3-5 and 8 exhibited moderately elevated in vitro cytotoxic potency towards the human epithelial cervical carcinoma (HeLa) cell line, with 4 as the best performer (IC50 value of 18 M). Apoptosis-inducing activity, assessed by the 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) assay, showed that the zinc complexes interacted with DNA and thereby interfered the DNA binding of several transcription factors to its promoter sites, thus inhibiting gene transcription required for the biological activity of cells. Accepted ManuscriptThis is an Accepted Manuscript, which has been through the RSC Publishing peer review process and has been accepted for publication.Accepted Manuscripts are published online shortly after acceptance, which is prior to technical editing, formatting and proof reading. This free service from RSC Publishing allows authors to make their results available to the community, in citable form, before publication of the edited article. This Accepted Manuscript will be replaced by the edited and formatted Advance Article as soon as this is available.To cite this manuscript please use its permanent Digital Object Identifier (DOI®), which is identical for all formats of publication.More information about Accepted Manuscripts can be found in the Information for Authors.Please note that technical editing may introduce minor changes to the text and/or graphics contained in the manuscript submitted by the author(s) which may alter content, and that the standard Terms & Conditions and the ethical guidelines that apply to the journal are still applicable. In no event shall the RSC be held responsible for any errors or omissions in these Accepted Manuscript manuscripts or any consequences arising from the use of any information contained in them. www.rsc.org/dalton ISSN 1477-9226 Dalton TransactionsAn international journal of inorganic chemistry 1477-9226(2010)

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“…From the expression variation of 23 proteins, it can be concluded that in IL6-treated cells there is a decrease in the level of ionized cellular calcium. Some cytokines are known to increase the cellular calcium level, as reported for IL1B (60), INFG (61) and IL8 (62). The protein levels of these three cytokines were actually found repressed by IL6.…”

Section: Discussionmentioning

confidence: 77%

Proteome Variations in Pancreatic Stellate Cells upon Stimulation with Proinflammatory Factors

Marzoq

Giese

Hoheisel

et al. 2013

Journal of Biological Chemistry

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Background: Stroma formation in pancreatic cancer is controlled via the activation of pancreatic stellate cells. Results: Pancreatic stellate cells demonstrate different proteomic and functional attributes following specific stimuli. Conclusion: The proteomic feature of pancreatic stellate cells shows TNF-␣ as a main contributor to activation. Significance: The shift of proteomes in activated cells may help in understanding the processes of stromal formation and finding new drug targets.

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Advanced Glycation End Products (AGEs) Induce Apoptosis via a Novel Pathway

Abstract: Advanced glycation end products (AGEs) accumulate in diabetic patients due to high blood glucose levels and cause multiple deleterious effects. In this study, we provide evidence that the AGE increased cell death, one such deleterious effect.

Cited by 65 publications

References 43 publications

Longistatin in tick saliva blocks advanced glycation end-product receptor activation

Longistatin in tick saliva blocks advanced glycation end-product receptor activation

Synthesis and characterization of some water soluble Zn(ii) complexes with (E)-N-(pyridin-2-ylmethylene)arylamines that regulate tumour cell death by interacting with DNA

Proteome Variations in Pancreatic Stellate Cells upon Stimulation with Proinflammatory Factors

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