Advanced in studies on anxiolytic effects of natural flavonoids

Lv, Yue-Wei; Guo, Jian-You; Liu, Yong; Liu, Jie; Wu, Min-Xuan; He, Yixin; Shi, Jingping

doi:10.4268/cjcmm20160108

Cited by 3 publications

(2 citation statements)

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“…In recent years, the anti-anxiety effect of natural flavonoids has attracted many scholars’ attention [ 23 , 24 , 25 , 26 ]. Its anti-anxiety effect may be related to their common structural characteristics: with hydroxyl in the 5,7 positions [ 27 ]. In addition to hesperidin, other bioactive chemical markers are all phenolic acids.…”

Section: Discussionmentioning

confidence: 99%

Identification of Bioactive Chemical Markers in Zhi zhu xiang Improving Anxiety in Rat by Fingerprint-Efficacy Study

Wang

Ding

et al. 2018

Molecules

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Zhi zhu xiang (ZZX for short) is the root and rhizome of Valeriana jatamansi Jones, which is a Traditional Chinese Medicine (TCM) used to treat various mood disorders for more than 2000 years, especially anxiety. The aim of the present work was to identify the bioactive chemical markers in Zhi zhu xiang improving anxiety in rats by a fingerprint-efficacy study. More specifically, the chemical fingerprint of ZZX samples collected from 10 different regions was determined by High Performance Liquid Chromatography (HPLC) and the similarity analyses were calculated based on 10 common characteristic peaks. The anti-anxiety effect of ZZX on empty bottle stimulated rats was examined through the Open Field Test (OFT) and the Elevated Plus Maze Test (EPM). Then we measured the concentration of CRF, ACTH, and CORT in rat’s plasma by the enzyme-linked immune sorbent assay (ELISA) kit, while the concentration of monoamine and metabolites (NE, DA, DOPAC, HVA, 5-HT, 5-HIAA) in the rat’s cerebral cortex and hippocampus was analysed by HPLC coupled with an Electrochemical Detector. At last, the fingerprint-efficacy study between chemical fingerprint and anti-anxiety effect of ZZX was accomplished by partial least squares regression (PLSR). As a result, we screened out four compounds (hesperidin, isochlorogenic acid A, isochlorogenic acid B and isochlorogenic acid C) as the bioactive chemical markers for the anti-anxiety effect of ZZX. The fingerprint-efficacy study we established might provide a feasible way and some elicitation for the identification of the bioactive chemical markers for TCM.

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Section: Discussionmentioning

confidence: 99%

Identification of Bioactive Chemical Markers in Zhi zhu xiang Improving Anxiety in Rat by Fingerprint-Efficacy Study

Wang

Ding

et al. 2018

Molecules

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“…The results of numerous studies have confirmed the anxiolytic effect of flavonoids by intracerebroventricular injection in laboratory animals [27][28][29]. For example, the low-dose of flavonoid baicalein (2 μg/rat) has been shown to exert antianxiety effects when injected directly into the central nervous system due to its gabaergic mechanism, which is independent of the benzodiazepine sites.…”

Section: Discussionmentioning

confidence: 84%

Effects of Intracerebroventricular Micro-injection of Kaempferol on Anxiety: Possible GABAergic Mechanism Involved

Zarei

Sarihi

Ahmadimoghaddam

et al. 2020

ajnpp

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Background and Objectives: Kaempferol (KM) is one of the most important plants with neuroprotection and analgesic effects. In addition, bicuculline (BIC) is a competitive antagonist of the GABAA ionotropic receptor (the most important targets of benzodiazepines and other anxiety suppressants). In this study, intracerebroventricular microinjection of KM on anxiety and its interaction with GABAergic mechanism were investigated in male rats. Materials and Methods: In this exploratory investigation, the male rats were divided into the following groups: control (saline), groups treated by KM (0.5 and 2 mg/rat), DMSO (1mg/rat), KM 0.5+BIC1 mg/rat, KM 0.5+BIC4 mg/rat, KM 2+BIC1 mg/rat, BIC groups (1, 4 mg/rat), and KM 2+BIC 4 mg/rat. Besides, an elevated plus-maze paradigm was used for the evaluation of the anxiety. Results: Statistical analysis revealed that the indices of TTOA in KM groups (0.5 and 2 mg/rat) significantly increased in comparison to the control group (P<0.05 and P<0.01, respectively). Moreover, regarding the involvement of the GABAergic system in the anxiolytic-like activity of KM, it was demonstrated that the TTOA related to co-administration of KM (0.5mg/rat) with bicuculline (1mg/rat) significantly reduced, compared to the control group (P<0.05). Conclusion: According to the obtained results, the use of KM can likely improve anxiety through GABAergic mechanism(s).

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A narrative review on the mechanism of natural flavonoids in improving glucolipid metabolism disorders

Niu,

Feng,

Peng

et al. 2024

Phytotherapy Research

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Glucolipid metabolism disorder (GLMD) is a complex chronic disease characterized by glucose and lipid metabolism disorders with a complex and diverse etiology and rapidly increasing incidence. Many studies have identified the role of flavonoids in ameliorating GLMD, with mechanisms related to peroxisome proliferator‐activated receptors, nuclear factor kappa‐B, AMP‐activated protein kinase, nuclear factor (erythroid‐derived 2)‐like 2, glucose transporter type 4, and phosphatidylinositol‐3‐kinase/protein kinase B pathway. However, a comprehensive summary of the flavonoid effects on GLMD is lacking. This study reviewed the roles and mechanisms of natural flavonoids with different structures in the treatment of GLMD reported globally in the past 5 years and provides a reference for developing flavonoids as drugs for treating GLMD.

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Advanced in studies on anxiolytic effects of natural flavonoids

Cited by 3 publications

References 0 publications

Identification of Bioactive Chemical Markers in Zhi zhu xiang Improving Anxiety in Rat by Fingerprint-Efficacy Study

Identification of Bioactive Chemical Markers in Zhi zhu xiang Improving Anxiety in Rat by Fingerprint-Efficacy Study

Effects of Intracerebroventricular Micro-injection of Kaempferol on Anxiety: Possible GABAergic Mechanism Involved

A narrative review on the mechanism of natural flavonoids in improving glucolipid metabolism disorders

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