Advanced Maternal Age and Offspring Outcomes: Reproductive Aging and Counterbalancing Period Trends

Barclay, Kieron J.; Myrskylä, Mikko

doi:10.1111/j.1728-4457.2016.00105.x

Cited by 100 publications

(76 citation statements)

References 72 publications

(82 reference statements)

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“…The positive association was partially reversed among mothers in their late 30 s or early 40 s in the unadjusted primary analysis, but continued in the adjusted primary or sibling comparison analyses. A previous analysis12 of maternal age using a subset (born 1965–1977) of the present data found similar results except for their sibling-comparison analysis adjusted for year of birth, which we consider unreliable (Supplementary Note online). A small (N = 277) study4243 of New Zealand children aged 3–10 and of relatively uniform socioeconomic background found that offspring height was independently positively associated with maternal and paternal age after adjustment for age, sex, birth weight, birth order and mid-parental height; a result the authors considered likely to persist into adulthood.…”

Section: Discussionsupporting

confidence: 84%

“…In the within-family context, the causal effect of parental age on offspring outcomes includes an indirect effect mediated by the offspring’s DOB12 (Fig. 4).…”

Section: Discussionmentioning

confidence: 99%

“…The commonly used practice of adjusting for year of birth (which is merely DOB with reduced precision) in a sibling-comparison analysis of parental age121316 does not solve this issue and may lead to additional confounding (Supplementary Note online). If the pathway mediated by DOB were the only association between parental age and the outcomes (i.e.…”

Section: Discussionmentioning

confidence: 99%

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Associations of parental age with health and social factors in adult offspring. Methodological pitfalls and possibilities

Carslake

Tynelius

Berg

et al. 2017

Sci Rep

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Parental age is increasing rapidly in many countries. Analysis of this potentially important influence on offspring well-being is hampered by strong secular trends and socioeconomic patterning and by a shortage of follow-up data for adult offspring. We used Swedish national data on up to 3,653,938 offspring to consider the associations of parental age with a suite of outcomes in adult offspring, comparing the results from an array of statistical methods for optimal causal inference. The offspring of older mothers had higher BMI, blood pressure, height, intelligence, non-cognitive ability and socioeconomic position. They were less likely to smoke or to be left-handed. Associations with paternal age were strongly, but not completely, attenuated by adjustment for maternal age. Estimates from the commonly-used sibling comparison method were driven primarily by a pathway mediated by offspring date of birth when outcomes showed strong secular trends. These results suggest that the intra-uterine and early life environments provided by older mothers may be detrimental to offspring cardiovascular health, but that their greater life experience and social position may bring intellectual and social advantages to their offspring. The analysis of parental age presents particular challenges, and further methodological developments are needed.

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Section: Discussionsupporting

confidence: 84%

“…In the within-family context, the causal effect of parental age on offspring outcomes includes an indirect effect mediated by the offspring’s DOB12 (Fig. 4).…”

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Associations of parental age with health and social factors in adult offspring. Methodological pitfalls and possibilities

Carslake

Tynelius

Berg

et al. 2017

Sci Rep

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“…Medical scholars have had a large interest in the effects of parents' age at birth have attracted attention, yet in a series of paper, Myrskylä and co-authors (Barclay and Myrskylä 2016;Myrskylä et al 2013) argue that the adverse effects of advanced parental age have been overstated, in particular in contexts of rapid change. It seems plausible that negative effects of large family size, and other resources constraints were large in earlier less wealthy societies with less government welfare support.…”

Section: Prior Research On the Relationship Between Family Size And mentioning

confidence: 99%

“…In fact, for many outcomes, any socio-economic gradient can easily be dwarfed by time trends. For example, Barclay and Myrskylä (2016) found that advanced maternal age was associate with lower levels of cognitive and physical outcomes, but the secular positive trend in ability resulting in being born later offset possible physiological effects of being born to an older mother. While the latter effect is not generated within the family, it can have substantial impact.…”

Section: The Socioeconomic and Demographic Transformations Of The 19 mentioning

confidence: 99%

SRRD_2016_10 Kolk & Hällsten Demographic and Educational Success of Decendants.pdf (Version: 1)

Kolk¹

2017

Preprint

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Demographic behavior and socioeconomic positions are inherited across generations, across both time and place. In this study we examine multigenerational dependencies in these dimensions over some 150 years in Sweden. We use a prospective approach where the eldest generation is the unit of analysis and the outcomes are lineage size and educational attainment in the youngest generation. Our data is a representative population of predominantly farmers born in the Skellefteå region in Northern Sweden in the 1860s and 1870s, and we follow these lineages until 2007. We follow our population during the fertility transition, industrial revolution, and educational expansion of tertiary education. Our results suggest that timing of birth, socio-economic position, and especially level of fertility are all central factors that explain the success of a lineage in terms of size, but also in terms of educational attainment. Later births allows the lineage to make use of social advancements and thus increase the proportion with tertiary education, higher fertility creates vast variation in lineage size, but also involves a quality-quantity trade-off of as the average level of education tend to decrease in subsequent generation. We also find prevailing effects of the eldest generation's occupation which are substantial in creating an educational advantage in the youngest generations. Importantly, these factors operate largely independently of each other in their association with reproductive and socio-economic success.

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Birth weight, birth order, and age at first solid food introduction influence child growth and body composition in 6‐ to 8‐year‐old Maya children: The importance of the first 1000 days of life

Sanchez‐Escobedo

Azcorra

Bogin

et al. 2020

American J Hum Biol

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Objectives: To analyze the relationship of birth weight, birth order, breastfeeding duration, and age of introduction of solid foods with height, fat mass, and fat-free mass in a sample of Maya children when aged 6 to 8 years old. Methods: We collected data on anthropometry, body composition, children's birth weight, birth order, early feeding practices, and household socioeconomic characteristics in a sample of 260 Maya children aged 6 to 8 years living in Merida and Motul, two cities in Yucatan, Mexico. Multiple regression models were performed to identify variables associated with height-forage (HAZ), fat mass index (FMI), and fat-free mass index (FFMI). The predictors included in the models were birth weight (kg), birth order, duration of breastfeeding (months), age at introduction of solid foods (months), maternal age (years), and height (cm). Models were adjusted for the influence of children's age and sex, maternal educational level, and household overcrowding. Results: HAZ was positively associated with child birthweight and maternal height and age, but inversely associated with birth order and age of introduction of solid foods. FMI was positively associated with birth weight, maternal age, and height, and negatively associated with birth order. FFMI was positively associated with maternal age and birth weight. Conclusions: These results are evidence of the importance of the first 1000 days of life for the growth and body composition of Maya children and contributed to understand the development of nutritional dual burden in this population.

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Advanced Maternal Age and Offspring Outcomes: Reproductive Aging and Counterbalancing Period Trends

Cited by 100 publications

References 72 publications

Associations of parental age with health and social factors in adult offspring. Methodological pitfalls and possibilities

Associations of parental age with health and social factors in adult offspring. Methodological pitfalls and possibilities

SRRD_2016_10 Kolk & Hällsten Demographic and Educational Success of Decendants.pdf (Version: 1)

Birth weight, birth order, and age at first solid food introduction influence child growth and body composition in 6‐ to 8‐year‐old Maya children: The importance of the first 1000 days of life

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Advanced Maternal Age and Offspring Outcomes: Reproductive Aging and Counterbalancing Period Trends

Cited by 100 publications

References 72 publications

Associations of parental age with health and social factors in adult offspring. Methodological pitfalls and possibilities

Associations of parental age with health and social factors in adult offspring. Methodological pitfalls and possibilities

SRRD_2016_10 Kolk &amp; Hällsten Demographic and Educational Success of Decendants.pdf (Version: 1)

Birth weight, birth order, and age at first solid food introduction influence child growth and body composition in 6‐ to 8‐year‐old Maya children: The importance of the first 1000 days of life

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Product

Resources

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SRRD_2016_10 Kolk & Hällsten Demographic and Educational Success of Decendants.pdf (Version: 1)