Advanced paternal age and the risk of spontaneous abortion: an analysis of the combined 2011–2013 and 2013–2015 National Survey of Family Growth

Nguyen, Brian; Chang, Erica J.; Bendikson, Kristin

doi:10.1016/j.ajog.2019.05.028

Cited by 40 publications

(38 citation statements)

References 41 publications

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“…Detailed descriptions of key characteristics for all included studies are summarised in Table I . With regard to the study designs of the 10 included studies, four were cohort studies ( de la Rochebrochard and Thonneau, 2002 ; Slama et al ., 2003 ; Nybo Andersen et al ., 2004 ; Slama et al ., 2005 ) and six were case-control studies ( Kleinhaus et al ., 2006 ; Maconochie et al ., 2007 ; Baba et al ., 2011 ; Jaleel and Khan, 2013 ; Xu et al ., 2014 ; Nguyen et al ., 2019 ). Two of the cohort studies ( de la Rochebrochard and Thonneau, 2002 ; Slama et al ., 2003 ) were retrospective studies, and two were prospective studies ( Nybo Andersen et al ., 2004 ; Slama et al ., 2005 ).…”

Section: Resultsmentioning

confidence: 99%

“…As shown in Table I , three studies took place in the USA ( Slama et al ., 2005 ; Kleinhaus et al ., 2006 ; Nguyen et al ., 2019 ) (one of these studies used data derived from a historic cohort; the Jerusalem Perinatal Study ( Kleinhaus et al ., 2006 )), two were in France ( de la Rochebrochard and Thonneau, 2002 ; Slama et al ., 2003 ) (one of these studies was based on the European Study of Infertility and Subfecundity, including data from Denmark, Germany, Italy and Spain ( de la Rochebrochard and Thonneau, 2002 )), and one each was in Denmark ( Nybo Andersen et al ., 2004 ), the UK ( Maconochie et al ., 2007 ), Japan ( Baba et al ., 2011 ), China ( Xu et al ., 2014 ) and Pakistan ( Jaleel and Khan, 2013 ). Seven studies were population-based ( de la Rochebrochard and Thonneau, 2002 ; Slama et al ., 2003 ; Nybo Andersen et al ., 2004 ; Slama et al ., 2005 ; Kleinhaus et al ., 2006 ; Maconochie et al ., 2007 ; Nguyen et al ., 2019 ), and three were hospital-based ( Baba et al ., 2011 ; Jaleel and Khan, 2013 ; Xu et al ., 2014 ). The sample sizes varied from 600 participants in a case-control study ( Jaleel and Khan, 2013 ) to 23 821 in the Danish study by Nybo Andersen et al ., (2004 ).…”

Section: Resultsmentioning

confidence: 99%

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Advanced paternal age is associated with an increased risk of spontaneous miscarriage: a systematic review and meta-analysis

Fossé

Hoorn

Lith

et al. 2020

Human Reproduction Update

172

103

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BACKGROUND Although spontaneous miscarriage is the most common complication of human pregnancy, potential contributing factors are not fully understood. Advanced maternal age has long been recognised as a major risk factor for miscarriage, being strongly related with fetal chromosomal abnormalities. The relation between paternal age and the risk of miscarriage is less evident, yet it is biologically plausible that an increasing number of genetic and epigenetic sperm abnormalities in older males may contribute to miscarriage. Previous meta-analyses showed associations between advanced paternal age and a broad spectrum of perinatal and paediatric outcomes. This is the first systematic review and meta-analysis on paternal age and spontaneous miscarriage. OBJECTIVE AND RATIONALE The aim of this systematic review and meta-analysis is to evaluate the effect of paternal age on the risk of spontaneous miscarriage. SEARCH METHODS PubMed, Embase and Cochrane databases were searched to identify relevant studies up to August 2019. The following free text and MeSH terms were used: paternal age, father’s age, male age, husband’s age, spontaneous abortion, spontaneous miscarriage, abortion, miscarriage, pregnancy loss, fetal loss and fetal death. PRISMA guidelines for systematic reviews and meta-analysis were followed. Original research articles in English language addressing the relation between paternal age and spontaneous miscarriage were included. Exclusion criteria were studies that solely focused on pregnancy outcomes following artificial reproductive technology (ART) and studies that did not adjust their effect estimates for at least maternal age. Risk of bias was qualitatively described for three domains: bias due to confounding, information bias and selection bias. OUTCOMES The search resulted in 975 original articles. Ten studies met the inclusion criteria and were included in the qualitative synthesis. Nine of these studies were included in the quantitative synthesis (meta-analysis). Advanced paternal age was found to be associated with an increased risk of miscarriage. Pooled risk estimates for miscarriage for age categories 30–34, 35–39, 40–44 and ≥45 years of age were 1.04 (95% CI 0.90, 1.21), 1.15 (0.92, 1.43), 1.23 (1.06, 1.43) and 1.43 (1.13, 1.81) respectively (reference category 25–29 years). A second meta-analysis was performed for the subgroup of studies investigating first trimester miscarriage. This showed similar pooled risk estimates for the first three age categories and a slightly higher pooled risk estimate for age category ≥45 years (1.74; 95% CI 1.26, 2.41). WIDER IMPLICATIONS Over the last decades, childbearing at later ages has become more common. It is known that frequencies of adverse reproductive outcomes, including spontaneous miscarriage, are higher in women with advanced age. We show that advanced paternal age is also associated with an increased risk of spontaneous miscarriage. Although the paternal age effect is less pronounced than that observed with advanced maternal age and residual confounding by maternal age cannot be excluded, it may have implications for preconception counselling of couples comprising an older aged male.

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Advanced paternal age is associated with an increased risk of spontaneous miscarriage: a systematic review and meta-analysis

Fossé

Hoorn

Lith

et al. 2020

Human Reproduction Update

172

103

View full text Add to dashboard Cite

show abstract

“…GDM was diagnosed if one or more of the following plasma GS levels were met or exceeded following the 75 g oral glucose tolerance test: at fasting ≥92 mg/dL, at 1 h ≥ 180 mg/dL, and at 2 h ≥ 153 mg/dL, according to the guidelines of the International Association of Diabetes and Pregnancy Study Groups [12]. Spontaneous abortion was defined as a spontaneous loss of a pregnancy before the 20th week of gestation [13]. PROM was defined as the rupture of the amniotic sac before the onset of labor.…”

Section: Definitionsmentioning

confidence: 99%

Relationship between anti-thyroid peroxidase antibody positivity and pregnancy-related and fetal outcomes in Euthyroid women: a single-center cohort study

Yuan

Sun

et al. 2020

BMC Pregnancy Childbirth

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Background: Thyroid autoimmunity (TAI) and subclinical hypothyroidism (SCH) have been associated with poor pregnancy and fetal outcomes. However, whether euthyroid women with anti-thyroid peroxidase antibody (TPOAb) positivity have a higher risk of poor pregnancy and fetal outcomes is debatable. Therefore, this study aimed to investigate the association between TPOAb positivity and pregnancy-related and fetal outcomes in euthyroid women. Methods: In total, 938 pregnant women participated in this prospective cohort study. The euthyroid group included 837 pregnant women and the TPOAb-positive group included 101 euthyroid pregnant women. Serum TPOAb, thyroglobulin antibody (TGAb), thyroid-stimulating hormone (TSH), and free thyroxine (FT4) levels were assessed. Pregnancy and fetal outcomes included gestational diabetes mellitus, spontaneous abortion, premature rupture of membranes, hypertensive disorders of pregnancy, preterm birth, fetal distress, low birth weight, fetal macrosomia, and small for gestational age infant. Results: Logistic regression analysis showed TPOAb positivity was not associated with an increased risk of poor pregnancy or fetal outcomes in euthyroid women. However, TPOAb-positive euthyroid women pregnant with a female fetus were independently associated with preterm births (OR: 4.511, 95% CI: 1.075-18.926) after adjustment for potential confounding factors.

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“…In terms of research that focuses on the effects of paternal age on their offspring, studies have often found conflicting results. Most analyses show that advanced age of the male partners is associated with lower pregnancy rate and a higher risk of early spontaneous pregnancy loss [6,7]. Conflicting studies found that male partner age was not associated with adverse obstetrical or perinatal outcomes [2,8].…”

Section: Introductionmentioning

confidence: 99%

Paternal age, body mass index, and semen volume are associated with chromosomal aberrations-related miscarriages in couples that underwent treatment by assisted reproductive technology

Wang

Liu

et al. 2020

Aging

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We investigated the effects of paternal characteristics, including age, body mass index (BMI), and semen parameters on chromosomal aberration-related miscarriages in couples that underwent treatment with assisted reproductive technology (ART). Single nucleotide polymorphism (SNP) array analysis showed chromosomal aberrations in 60.2% (557/925) of miscarried fetuses, including trisomy in 73.1% (407/557) of cases. There were higher chromosomal aberration rates in fetuses for men aged 20-24 years and ≥30 years compared with controls. After adjusting for age and BMI of the female partners, and the BMI and semen parameters of the males, there was no statistically significant effect of paternal age ≥30 years on the risk of chromosomal aberrations-related miscarriages. However, the odds of chromosomal abnormality-related miscarriage were 148% higher for the youngest fathers (age: 20-24 years) than fathers aged 25-29 years [adjusted odds ratio (OR): 2.48, 95% confidence interval (CI): 1.03-5.96; P=0.042]. Furthermore, high male BMI (adjusted OR: 1.56, 95% CI: 1.14-2.14; P=0.005) and low semen volume (adjusted OR: 2.09, 95% CI: 1.06-4.11; P=0.034) were associated with increased risk of chromosomal aberration-related miscarriages. These findings demonstrate that very young paternal age, high BMI, and low semen volume are associated with increased risk of chromosomal aberration-related miscarriages in couples undergoing ART treatment.

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Advanced paternal age and the risk of spontaneous abortion: an analysis of the combined 2011–2013 and 2013–2015 National Survey of Family Growth

Cited by 40 publications

References 41 publications

Advanced paternal age is associated with an increased risk of spontaneous miscarriage: a systematic review and meta-analysis

Advanced paternal age is associated with an increased risk of spontaneous miscarriage: a systematic review and meta-analysis

Relationship between anti-thyroid peroxidase antibody positivity and pregnancy-related and fetal outcomes in Euthyroid women: a single-center cohort study

Paternal age, body mass index, and semen volume are associated with chromosomal aberrations-related miscarriages in couples that underwent treatment by assisted reproductive technology

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