Advancement of Nanobiomaterials to Deliver Natural Compounds for Tissue Engineering Applications

Kumar, Sathish Sundar Dhilip; Abrahamse, Heidi

doi:10.3390/ijms21186752

Cited by 18 publications

(14 citation statements)

References 184 publications

(181 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…There has been increasing evidence that the biological properties of the scaffold affect various types of cellular behavior, including cell compatibility, viability, proliferation, and migration [ 104 ]. To address another important pathway of nanoparticle-incorporated biomaterials towards skin penetration, Kumar et al [ 105 ] discussed the outcomes of using natural compound particles with incorporated biomaterials in skin tissue engineering applications. Based on available knowledge from the findings, the researchers used nanoparticles as carriers, due to their biological, electrical, mechanical and antibacterial properties [ 36 ].…”

Section: Biological Cellular Effects and Signaling Pathwaysmentioning

confidence: 99%

The Effect of Nanoparticle-Incorporated Natural-Based Biomaterials towards Cells on Activated Pathways: A Systematic Review

et al. 2022

View full text Add to dashboard Cite

The advancement of natural-based biomaterials in providing a carrier has revealed a wide range of benefits in the biomedical sciences, particularly in wound healing, tissue engineering and regenerative medicine. Incorporating nanoparticles within polymer composites has been reported to enhance scaffolding performance, cellular interactions and their physico-chemical and biological properties in comparison to analogue composites without nanoparticles. This review summarized the current knowledge of nanoparticles incorporated into natural-based biomaterials with effects on their cellular interactions in wound healing. Although the mechanisms of wound healing and the function of specific cells in wound repair have been partially described, many of the underlying signaling pathways remain unknown. We also reviewed the current understanding and new insights into the wingless/integrated (Wnt)/β-catenin pathway and other signaling pathways of transforming growth factor beta (TGF-β), Notch, and Sonic hedgehog during wound healing. The findings demonstrated that most of the studies reported positive outcomes of biomaterial scaffolds incorporated with nanoparticles on cell attachment, viability, proliferation, and migration. Combining therapies consisting of nanoparticles and biomaterials could be promising for future therapies and better outcomes in tissue engineering and regenerative medicine.

show abstract

Section: Biological Cellular Effects and Signaling Pathwaysmentioning

confidence: 99%

The Effect of Nanoparticle-Incorporated Natural-Based Biomaterials towards Cells on Activated Pathways: A Systematic Review

et al. 2022

View full text Add to dashboard Cite

show abstract

“…A parallel mass change resulting from variable composition of apatite is equal to 1.0396. Introduction of volume correction resulting from the change in crystallographic parameter "a" equal to 1/(a air /a DEJ ) 2 gives a small correction, leading to a value of 1.0333. Parameter "c" was not considered since it is nearly the same in extreme points.…”

Section: Energetic Relationshipsmentioning

confidence: 99%

“…There is a need to develop new materials for dentistry, especially dedicated to fillings and prosthesis purposes. Recently, a number of studies were focused on the possible application of various nanomaterials, such as titanium alloys [1] or hydroxyapatite nanocomposites [2], for dentistry application and bone and tissue restoration. Nanocomposites showed benefits for dental applications such as antibacterial effects, Ca and PO 4 3− ion release or prevention from demineralization and hardness lost [3].…”

Section: Introductionmentioning

confidence: 99%

Novel Approach to Tooth Chemistry: Quantification of Human Enamel Apatite in Context for New Biomaterials and Nanomaterials Development

Kuczumow¹,

Chałas

Nowak³

et al. 2020

IJMS

View full text Add to dashboard Cite

A series of linear profiles of the elements of the enamel in human molar teeth were made with the use of an electron microprobe and a Raman microscope. It is postulated that the enamel can be treated as the superposition of variable “overbuilt” enamel on the stable “core” enamel at the macro-, micro- and nanoscale level. The excessive values characterize the “overbuilt enamel”. All the profiles of excessive parameters along the enamel thickness from the enamel surface to the dentin enamel junction (DEJ) can be approximated very precisely with the use of exponential functions, where Ca, P, Cl and F spatial profiles are decaying while Mg, Na, K and CO32− ones are growing distributions. The “overbuilt” apatite formed on the boundary with DEJ, enriched in Na, Mg, OH and carbonates, reacts continuously with Ca, Cl and F, passing into an acid-resistant form of the “overbuilt” enamel. The apparent phases arriving in boundary regions of the “overbuilt enamel” were proposed. Microdiffraction measurements reveal relative variation of energy levels during enamel transformations. Our investigations are the milestones for a further new class of biomaterial and nanomaterial development for biomedical applications.

show abstract

“…In the field of tissue engineering, the biomaterials that are developed must be biocompatible and have a specific mechanical resistance to function as a support during the repair of damaged tissue. Using natural materials such as biopolymers can offer benefits for various applications, enhancing their properties, which are convenient for studying and treating diseases [ 2 ]. Poly (lactic acid) (PLA) is a biopolymer known to be eco-friendly, which has the characteristic of being a biodegradable polymer produced from the fermentation of carbohydrates.…”

Section: Introductionmentioning

confidence: 99%

Recent advances in modified poly (lactic acid) as tissue engineering materials

et al. 2023

View full text Add to dashboard Cite

As an emerging science, tissue engineering and regenerative medicine focus on developing materials to replace, restore or improve organs or tissues and enhancing the cellular capacity to proliferate, migrate and differentiate into different cell types and specific tissues. Renewable resources have been used to develop new materials, resulting in attempts to produce various environmentally friendly biomaterials. Poly (lactic acid) (PLA) is a biopolymer known to be biodegradable and it is produced from the fermentation of carbohydrates. PLA can be combined with other polymers to produce new biomaterials with suitable physicochemical properties for tissue engineering applications. Here, the advances in modified PLA as tissue engineering materials are discussed in light of its drawbacks, such as biological inertness, low cell adhesion, and low degradation rate, and the efforts conducted to address these challenges toward the design of new enhanced alternative biomaterials.

show abstract

Advancement of Nanobiomaterials to Deliver Natural Compounds for Tissue Engineering Applications

Cited by 18 publications

References 184 publications

The Effect of Nanoparticle-Incorporated Natural-Based Biomaterials towards Cells on Activated Pathways: A Systematic Review

The Effect of Nanoparticle-Incorporated Natural-Based Biomaterials towards Cells on Activated Pathways: A Systematic Review

Novel Approach to Tooth Chemistry: Quantification of Human Enamel Apatite in Context for New Biomaterials and Nanomaterials Development

Recent advances in modified poly (lactic acid) as tissue engineering materials

Contact Info

Product

Resources

About