The Effect of Nanoparticle-Incorporated Natural-Based Biomaterials towards Cells on Activated Pathways: A Systematic Review

Fadilah, Nur Izzah Md; Isa, Isma Liza Mohd; Zaman, Wan Safwani Wan Kamarul; Tabata, Yasuhiko; Fauzi, Mh Busra

doi:10.3390/polym14030476

Cited by 43 publications

(26 citation statements)

References 129 publications

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“…Recent developments in wound dressing-based therapy have introduced and incorporated the use of nanoparticles and nanomaterials in biomedical applications to help create natural polymeric-based dressings. 35 This is due to their amazing properties such as non-allergenic nature, biocompatibility, biodegradability, and low toxicity. Examples are electrospun nanofibers which have been useful because of their nanoscale diameter as well as their ability to form a nonwoven structure or membrane-based materials with suitable porosity.…”

Section: Therapeutic Approaches Using Tissue Engineered Productsmentioning

confidence: 99%

Cell secretomes for wound healing and tissue regeneration: Next generation acellular based tissue engineered products

et al. 2022

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Wound represents a significant socioeconomic burden for both affected individuals and as a whole healthcare system. Accordingly, stem cells have garnered attention due to their differentiation capacity and ability to aid tissue regeneration by releasing biologically active molecules, found in the cells’ cultivated medium which known as conditioned medium (CM) or secretomes. This acellular approach provides a huge advantage over conventional treatment options, which are mainly used cellular treatment at wound closure. Interestingly, the secretomes contained the cell-secreted proteins such as growth factors, cytokines, chemokines, extracellular matrix (ECM), and small molecules including metabolites, microvesicles, and exosomes. This review aims to provide a general view on secretomes and how it is proven to have great potential in accelerating wound healing. Utilizing the use of secretomes with its secreted proteins and suitable biomaterials for fabrications of acellular skin substitutes can be promising in treating skin loss and accelerate the healing process.

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Section: Therapeutic Approaches Using Tissue Engineered Productsmentioning

confidence: 99%

Cell secretomes for wound healing and tissue regeneration: Next generation acellular based tissue engineered products

et al. 2022

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“…In comparison to 2.5 and 7.5% graphene additions, 5% graphene additions showed superior mechanical strength (36.59 MPa tensile, 40.25 MPa flexural and 31.68 kg/m 2 impact). Better stress distribution and transmission may account for the improved mechanical properties of graphene in resin at a concentration of 5 Wt.% [27,28]. Adding more filled graphene to the polymer matrix influenced the decohesion bonding between the fibre and the matrix by increasing the conveyance and size of holes [29].…”

Section: Effect Of Graphene Fibre Additionsmentioning

confidence: 99%

Effect of Mechanical Properties on Fibre Addition of Flax and Graphene-Based Bionanocomposites

Natrayan

Kaliappan²,

Sethupathy³

et al. 2022

International Journal of Chemical Engineering

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Natural fibre-based polymer nanocomposites have played an essential role in many industry domains for four to five years because of their strong mechanical and physical qualities. The primary goal of this research is to establish the mechanical and morphological properties of nanocomposite materials in natural environments. Flax fibre was employed as a reinforcement, nanographene powder was used as a filler, and epoxy resin was used as a matrix material to achieve the goals above, keeping the following restrictions in mind: (i) fibre length (15, 30 and 45 mm), (ii) fibre content (10, 15 and 20 mm), and (iii) wt.% of nanofiller (2.5, 5 and 7.5 wt.%). The composite materials were laminated using the compression moulding process per the Taguchi L9 design. The mechanical characteristics of the material, such as flexural, tensile, and impact properties, were examined according to ASTM standards. The mechanical characteristics of combinations A2, B2, and C2 are the best when compared to other combinations. The graphene-based nanocomposites revealed that 2.5 wt.% graphene contributes 33.08% of mechanical properties, the 5 wt.% graphene contributes 36.4%, and the 7.5 wt.% graphene contributes 30.53%. Including 5 wt.% graphene content provides the highest mean values of mechanical strength like 36.59 MPa tensile, 40.25 MPa flexural, and 31.68 kg/m2 of impact. Scanning electron microscopy (SEM) images of the cracked specimens were used better to understand the failure process of composites during mechanical testing.

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“…Recent advancement of biomaterials as a delivery system has provided a broad range of benefits in tissue engineering and regenerative medicine. [78] Biomaterials can transport exogenous therapeutic molecules, including growth factors (PDGF, FGF, IGF-I, and TGF-𝛽1), [79,80,81,82] cellular regulator, drug or inhibitor (anti-TNF𝛼, IL-1ra, celecoxib, rapamycin, NF-𝜅B decoy) [83,84,85,86] from the cargo to the target site specifically to regulate cellular signaling, thereby dictating cellular responses, including anticatabolic, antioxidative, antiapoptotic, anti-inflammatory, and anabolic effects for IVD regeneration. [87] This delivery system provides sustained release of the therapeutic molecules over time for a longterm efficacy.…”

Section: Therapeutic Molecules To Regulate Cellular Responses For Tis...mentioning

confidence: 99%

Intervertebral Disc Degeneration: Biomaterials and Tissue Engineering Strategies toward Precision Medicine

Isa

Mokhtar

Abbah

et al. 2022

Adv Healthcare Materials

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Intervertebral disc degeneration is a common cause of discogenic low back pain resulting in significant disability. Current conservative or surgical intervention treatments do not reverse the underlying disc degeneration or regenerate the disc. Biomaterial-based tissue engineering strategies exhibit the potential to regenerate the disc due to their capacity to modulate local tissue responses, maintain the disc phenotype, attain biochemical homeostasis, promote anatomical tissue repair, and provide functional mechanical support. Despite preliminary positive results in preclinical models, these approaches have limited success in clinical trials as they fail to address discogenic pain. This review gives insights into the understanding of intervertebral disc pathology, the emerging concept of precision medicine, and the rationale of personalized biomaterial-based tissue engineering tailored to the severity of the disease targeting early, mild, or severe degeneration, thereby enhancing the efficacy of the treatment for disc regeneration and ultimately to alleviate discogenic pain. Further research is required to assess the relationship between disc degeneration and lower back pain for developing future clinically relevant therapeutic interventions targeted towards the subgroup of degenerative disc disease patients.

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The Effect of Nanoparticle-Incorporated Natural-Based Biomaterials towards Cells on Activated Pathways: A Systematic Review

Cited by 43 publications

References 129 publications

Cell secretomes for wound healing and tissue regeneration: Next generation acellular based tissue engineered products

Cell secretomes for wound healing and tissue regeneration: Next generation acellular based tissue engineered products

Effect of Mechanical Properties on Fibre Addition of Flax and Graphene-Based Bionanocomposites

Intervertebral Disc Degeneration: Biomaterials and Tissue Engineering Strategies toward Precision Medicine

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