Advances in Antimicrobial Organic and Inorganic Nanocompounds in Biomedicine

Wang, Chen yu; Makvandi, Pooyan; Zare, Ehsan Nazarzadeh; Tay, Franklin R.; Niu, Li Na

doi:10.1002/adtp.202000024

Cited by 100 publications

(65 citation statements)

References 225 publications

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“…Chitosan, polyethyleneimine, poly-l-lysine and polyvinylamine are some of the most practical examples of the contact mode (Elbourne et al 2017;Morais et al 2016). Using surface functionalization with antibacterial polymers has been shown to be advantageous over the type of antibacterial textiles, in which antibacterial nanoparticles like silver nanoparticles are incorporated in the fiber since in the former method, the antibacterial agents are as a part of fabrics' structure with negligible leaching, their probable toxicity effects are reduced, and they show higher application efficiency during a longer time (Wang et al 2020e;Timma et al 2019).…”

Section: Antimicrobial Textilesmentioning

confidence: 99%

Functionalization of polymers and nanomaterials for water treatment, food packaging, textile and biomedical applications: a review

et al. 2020

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The inert nature of most commercial polymers and nanomaterials results in limitations of applications in various industrial fields. This can be solved by surface modifications to improve physicochemical and biological properties, such as adhesion, printability, wetting and biocompatibility. Polymer functionalization allows to graft specific moieties and conjugate molecules that improve material performances. In the last decades, several approaches have been designed in the industry and academia to graft functional groups on surfaces. Here, we review surface decoration of polymers and nanomaterials, with focus on major industrial applications in the medical field, textile industry, water treatment and food packaging. We discuss the advantages and challenges of polymer functionalization. More knowledge is needed on the biology behind cell–polymer interactions, nanosafety and manufacturing at the industrial scale.

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Section: Antimicrobial Textilesmentioning

confidence: 99%

Functionalization of polymers and nanomaterials for water treatment, food packaging, textile and biomedical applications: a review

et al. 2020

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“…Silver has been used for wound healing soon after its discovery as an effective antimicrobial agent. It can be used as a solid state (powder) or even salt solutions for wound treatment [23,24]. Although it has been used for a very long time, the exact mechanism of action of silver nanoparticles remained partially unknown.…”

Section: Antimicrobial Therapymentioning

confidence: 99%

Functionalization of Polymers and Nanomaterials for Biomedical Applications: Antimicrobial Platforms and Drug Carriers

et al. 2020

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The use of polymers and nanomaterials has vastly grown for industrial and biomedical sectors during last years. Before any designation or selection of polymers and their nanocomposites, it is vital to recognize the targeted applications which require these platforms to be modified. Surface functionalization to introduce the desired type and quantity of reactive functional groups to target a cell or tissue in human body is a pivotal approach to improve the physicochemical and biological properties of these materials. Herein, advances in the functionalized polymer and nanomaterials surfaces are highlighted along with their applications in biomedical fields, e.g., antimicrobial therapy and drug delivery.

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“…Various drug delivery systems have been exploited over the last years in the therapeutic strategies related to Tb: metal NPs of Ni, Ag, Au [132,133], metal complexes of antibiotics [134], as well as polymers with antimicrobial properties, both decorated with AMPs and not. This latter strategy has the advantage to combine synergistically the effects of bioactive polymer matrices with drugs [135][136][137].…”

Section: Delivery Systems For Antibacterial Compounds In Tbmentioning

confidence: 99%

Metal–Peptide Complexes as Promising Antibiotics to Fight Emerging Drug Resistance: New Perspectives in Tuberculosis

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Benedictis

et al. 2020

Antibiotics

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In metal-peptide interactions, cations form stable complexes through bonds with coordinating groups as side chains of amino acids. These compounds, among other things, exert a wide variety of antimicrobial activities through structural changes of peptides upon metal binding and redox chemistry. They exhibit different mechanisms of action (MOA), including the modification of DNA/RNA, protein and cell wall synthesis, permeabilization and modulation of gradients of cellular membranes. Nowadays, the large increase in antibiotic resistance represents a crucial problem to limit progression at the pandemic level of the diseases that seemed nearly eradicated, such as tuberculosis (Tb). Mycobacterium tuberculosis (Mtb) is intrinsically resistant to many antibiotics due to chromosomal mutations which can lead to the onset of novel strains. Consequently, the maximum pharmaceutical effort should be focused on the development of new therapeutic agents and antimicrobial peptides can represent a valuable option as a copious source of potential bioactive compounds. The introduction of a metal center can improve chemical diversity and hence specificity and bioavailability while, in turn, the coordination to peptides of metal complexes can protect them and enhance their poor water solubility and air stability: the optimization of these parameters is strictly required for drug prioritization and to obtain potent inhibitors of Mtb infections with novel MOAs. Here, we present a panoramic review of the most recent findings in the field of metal complex-peptide conjugates and their delivery systems with the potential pharmaceutical application as novel antibiotics in Mtb infections.

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Advances in Antimicrobial Organic and Inorganic Nanocompounds in Biomedicine

Cited by 100 publications

References 225 publications

Functionalization of polymers and nanomaterials for water treatment, food packaging, textile and biomedical applications: a review

Functionalization of polymers and nanomaterials for water treatment, food packaging, textile and biomedical applications: a review

Functionalization of Polymers and Nanomaterials for Biomedical Applications: Antimicrobial Platforms and Drug Carriers

Metal–Peptide Complexes as Promising Antibiotics to Fight Emerging Drug Resistance: New Perspectives in Tuberculosis

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