Advances in biotechnological production of butyric acid

Zigová, Jana; Šturdı́k, Ernest

doi:10.1038/sj.jim.2900795

Cited by 156 publications

(86 citation statements)

References 38 publications

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“…Acetic acid production reached its highest at 15 g L -1 of glucose initial concentration at a D of 0.23 h -1 , followed by 10 g L -1 at the same dilution rate. At elevated concentration of the feed substrate, acetic acid production is reduced possibly due to the formation of other products besides butyric acid, like solvents or hydrogen [36][37][38]. This would be consistent with the observations associated with alkali consumption and the poor carbon recoveries observed at high sugar concentrations.…”

Section: Product Formation On a Continuously Stirred Tank Reactor (Cssupporting

confidence: 80%

“…butyricum is a mixed acid producer, simultaneously with other metabolic products as solvents i.e. ethanol, butanol or vicinal diaketones, glycerol or 1.3 propandiol [35][36][37]. The patterns of acids production exhibit certain similarities with acetic and butyric acid at high glucose concentration (15 to 28 g L -1 ), being initially increased at low dilution rates followed by dramatic decreases as the dilution rate is increased ( Table 1).…”

Section: Product Formation On a Continuously Stirred Tank Reactor (Csmentioning

confidence: 95%

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Intensive Production of Carboxylic Acids Using <em>Cl. butyricum</em> in a Membrane Bioreactor (MBR)

Tajarudin¹,

Zacharof²,

Ratanapongleka³

et al. 2018

Preprint

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This work reports of the use of a bench scale chemostat (CSTR) in continuous mode and of a pilot scale membrane bioreactor (MBR) in fed-batch mode to intensively produce acetic and butyric acids using Cl. butyricum grown on synthetic media. These studies were then used to perform a cost estimation study of the MBR system to assess the potential economic impact of this proposed methodology. The MBR system was found highly productive reaching 37.88 g L -1 h-1 of acetic and 14.44 g L -1 h -1 of volumetric cell productivity, favoring acetic acid production to butyric at a ratio 3:1. The cost of preparation and production of carboxylic acids using this system was found as 0.0062 £PS/kg respectively and an up to 99% carbon recovery.

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Section: Product Formation On a Continuously Stirred Tank Reactor (Cssupporting

confidence: 80%

Section: Product Formation On a Continuously Stirred Tank Reactor (Csmentioning

confidence: 95%

Intensive Production of Carboxylic Acids Using <em>Cl. butyricum</em> in a Membrane Bioreactor (MBR)

Tajarudin¹,

Zacharof²,

Ratanapongleka³

et al. 2018

Preprint

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“…Butyric acid is also used in the pharmaceutical industry. Many processes have already been proposed for butyrate production by fermentation (Zigová and Šturdik, 2000). Nevertheless, fermentation processes have not yet been used commercially because of low product mass concentrations in the fermentation broth (20-30 g / L) and also because of the acetate that is produced simultaneously with butyrate.…”

Section: Introductionmentioning

confidence: 99%

Liquid - liquid equilibria of the water + butyric acid + decanol ternary system

Kırbaşlar

2006

Braz. J. Chem. Eng.

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-Liquid-liquid equilibrium (LLE) data for the water + butyric acid + decanol ternary system were determined experimentally at temperatures of 298.15, 308.15 and 318.15 K. Complete phase diagrams were obtained by determining the solubility curve and the tie lines. The reliability of the experimental tie line data was confirmed with the Othmer-Tobias correlation. The UNIFAC method was used to predict the phase equilibrium of the system using the interaction parameters for groups CH 3 , CH 2 , COOH, OH and H 2 O determined experimentally. Distribution coefficients and separation factors were evaluated for the immiscibility region.

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“…One strain of C. butyricum preserved in our lab was screened and identified as a probiotic bacterium (Kong et al, 2004 (Zigová and Šturdik, 2000). In order to obtain a higher quantity of butyric acid, there is one important parameter which should be investigated, the pH.…”

Section: Introductionmentioning

confidence: 99%

Batch and fed-batch production of butyric acid by Clostridium butyricum ZJUCB

Kong

Chen

et al. 2005

J Zheijang Univ Sci B

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Abstract:The production of butyric acid by Clostridium butyricum ZJUCB at various pH values was investigated. In order to study the effect of pH on cell growth, butyric acid biosynthesis and reducing sugar consumption, different cultivation pH values ranging from 6.0 to 7.5 were evaluated in 5-L bioreactor. In controlled pH batch fermentation, the optimum pH for cell growth and butyric acid production was 6.5 with a cell yield of 3.65 g/L and butyric acid yield of 12.25 g/L. Based on these results, this study then compared batch and fed-batch fermentation of butyric acid production at pH 6.5. Maximum value (16.74 g/L) of butyric acid concentration was obtained in fed-batch fermentation compared to 12.25 g/L in batch fermentation. It was concluded that cultivation under fed-batch fermentation mode could enhance butyric acid production significantly (P<0.01) by C. butyricum ZJUCB.

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Advances in biotechnological production of butyric acid

Cited by 156 publications

References 38 publications

Intensive Production of Carboxylic Acids Using <em>Cl. butyricum</em> in a Membrane Bioreactor (MBR)

Intensive Production of Carboxylic Acids Using <em>Cl. butyricum</em> in a Membrane Bioreactor (MBR)

Liquid - liquid equilibria of the water + butyric acid + decanol ternary system

Batch and fed-batch production of butyric acid by Clostridium butyricum ZJUCB

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