Advances in carbon nanomaterials for immunotherapy

Azevedo, Silvana; Costa‐Almeida, Raquel; Santos, Susana G.; Magalhães, Fernão D.; Pinto, Artur M.

doi:10.1016/j.apmt.2022.101397

Cited by 23 publications

(34 citation statements)

References 165 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Pre-clinical research seeks to clarify the mechanisms of action, drug delivery systems, and treatment safety, as well as the efficacy and stability of nanomedicines in cancer therapy, in order to prevent potentially expensive limitations that might hinder future investments and developments [ 197 , 198 ]. As a result, selecting suitable pre-clinical models is critical for understanding the effects of nanomedicine therapies on the immune system and lowering the risks for clinical applications.…”

Section: Challenges and Opportunitiesmentioning

confidence: 99%

“…As a result, selecting suitable pre-clinical models is critical for understanding the effects of nanomedicine therapies on the immune system and lowering the risks for clinical applications. Although rodent models are the most commonly used to research immune responses to treatments, there are significant differences between them and human immune responses in terms of immune cell development, activation, complexity, proliferation, and function [ 198 ]. Moreover, the commonly used mouse xenograph models tend to overestimate nanomedicine’s effectiveness due to increased accumulation at the tumor site induced by an exaggerated EPR effect [ 197 ].…”

Section: Challenges and Opportunitiesmentioning

confidence: 99%

See 1 more Smart Citation

Metal-Organic Frameworks Applications in Synergistic Cancer Photo-Immunotherapy

et al. 2023

Self Cite

View full text Add to dashboard Cite

Conventional cancer therapies, such as radiotherapy and chemotherapy, can have long-term side effects. Phototherapy has significant potential as a non-invasive alternative treatment with excellent selectivity. Nevertheless, its applicability is restricted by the availability of effective photosensitizers and photothermal agents, and its low efficacy when it comes to avoiding metastasis and tumor recurrence. Immunotherapy can promote systemic antitumoral immune responses, acting against metastasis and recurrence; however, it lacks the selectivity displayed by phototherapy, sometimes leading to adverse immune events. The use of metal-organic frameworks (MOFs) in the biomedical field has grown significantly in recent years. Due to their distinct properties, including their porous structure, large surface area, and inherent photo-responsive properties, MOFs can be particularly useful in the fields of cancer phototherapy and immunotherapy. MOF nanoplatforms have successfully demonstrated their ability to address several drawbacks associated with cancer phototherapy and immunotherapy, enabling an effective and low-side-effect combinatorial synergistical treatment for cancer. In the coming years, new advancements in MOFs, particularly regarding the development of highly stable multi-function MOF nanocomposites, may revolutionize the field of oncology.

show abstract

Section: Challenges and Opportunitiesmentioning

confidence: 99%

Section: Challenges and Opportunitiesmentioning

confidence: 99%

Metal-Organic Frameworks Applications in Synergistic Cancer Photo-Immunotherapy

et al. 2023

Self Cite

View full text Add to dashboard Cite

show abstract

“…Bioaccumulation in the major organs or tissues, impurities/contamination, dosage, ROS generation, and particle size are some of the biggest concerns regarding the use of nano-scaled materials [ 125 , 126 , 127 , 128 ]. Graphene has been widely researched for biomedical applications and has demonstrated great properties for its use in cancer treatment, despite controversial results regarding its biosafety [ 126 , 129 ]. BP has been demonstrated to have higher biocompatibility than graphene, especially when incorporated in biopolymers or surface-functionalized [ 130 ].…”

Section: 2d Nanomaterials Polymeric Composites For Biomedical Applica...mentioning

confidence: 99%

New Polymeric Composites Based on Two-Dimensional Nanomaterials for Biomedical Applications

2022

Self Cite

View full text Add to dashboard Cite

The constant evolution and advancement of the biomedical field requires robust and innovative research. Two-dimensional nanomaterials are an emerging class of materials that have risen the attention of the scientific community. Their unique properties, such as high surface-to-volume ratio, easy functionalization, photothermal conversion, among others, make them highly versatile for a plethora of applications ranging from energy storage, optoelectronics, to biomedical applications. Recent works have proven the efficiency of 2D nanomaterials for cancer photothermal therapy (PTT), drug delivery, tissue engineering, and biosensing. Combining these materials with hydrogels and scaffolds can enhance their biocompatibility and improve treatment for a variety of diseases/injuries. However, given that the use of two-dimensional nanomaterials-based polymeric composites for biomedical applications is a very recent subject, there is a lot of scattered information. Hence, this review gathers the most recent works employing these polymeric composites for biomedical applications, providing the reader with a general overview of their potential.

show abstract

“…Thus, immobilization on other materials has been proposed to decrease cellular internalization [25] . Graphene-based materials (GBM) are promising particles with larger sizes –hundreds to thousands of nanometers– for reduced internalization, showing good biocompatibility at high concentrations in vitro and in vivo , as well as biodegradation by neutrophils or the human enzyme myeloperoxidase [26,27] . In particular, reduced graphene oxide (rGO) is a popular GBM with greater hemocompatibility than graphene oxide [28,29] that has been shown to promote myogenic differentiation with low reduction in cell viability [13] .…”

Section: Introductionmentioning

confidence: 99%

3D printed magneto-active microfiber scaffolds for remote stimulation of 3Din vitroskeletal muscle models

Servin

Dahri

Meneses

et al. 2023

Preprint

Self Cite

View full text Add to dashboard Cite

Tunable culture platforms that guide cellular organization and mechanically stimulate skeletal muscle development are still unavailable due to limitations in biocompatibility and actuation triggered without contact. This study reports the rational design and fabrication of magneto-active microfiber meshes with controlled hexagonal microstructures via melt electrowriting (MEW) of a thermoplastic/graphene/iron oxide composite. In situ deposition of iron oxide nanoparticles on oxidized graphene yielded homogeneously dispersed magnetic particles with sizes above 0.5 micrometer and low aspect ratio, preventing cellular internalization and toxicity. With these fillers, homogeneous magnetic composites with very high magnetic filler content (up to 10 wt.%) were obtained and successfully processed in a solvent-free manner for the first time. MEW of magnetic composites enabled the skeletal muscle-inspired design of hexagonal scaffolds with tunable fiber diameter, reconfigurable modularity, and zonal distribution of magneto-active and nonactive material. Importantly, the hexagonal microstructures displayed elastic deformability under tension, mitigating the mechanical limitations due to high filler content. External magnetic fields below 300 mT were sufficient to trigger out-of-plane reversible deformation leading to effective end-to-end length decrease up to 17%. Moreover, C2C12 myoblast culture on 3D Matrigel/collagen/MEW scaffolds showed that the presence of magnetic particles in the scaffolds did not significantly affect viability after 8 days with respect to scaffolds without magnetic filler. Importantly, in vitro culture demonstrated that myoblasts underwent differentiation at similar rates regardless of the presence of magnetic filler. Overall, these innovative microfiber scaffolds were proven as a magnetically deformable platform suitable for dynamic culture of skeletal muscle with potential for in vitro disease modeling.

show abstract

Advances in carbon nanomaterials for immunotherapy

Cited by 23 publications

References 165 publications

Metal-Organic Frameworks Applications in Synergistic Cancer Photo-Immunotherapy

Metal-Organic Frameworks Applications in Synergistic Cancer Photo-Immunotherapy

New Polymeric Composites Based on Two-Dimensional Nanomaterials for Biomedical Applications

3D printed magneto-active microfiber scaffolds for remote stimulation of 3Din vitroskeletal muscle models

Contact Info

Product

Resources

About