Advances in epithelial kinetics—An oral view

Hume, W.J.; Potten, Christopher S

doi:10.1111/j.1600-0714.1979.tb01618.x

Cited by 65 publications

(41 citation statements)

References 87 publications

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“…S2B–C). The evidences that these proliferating cells could undergo significant replication and expressed no differentiated markers suggests that these cells might be “transient amplifying cells” in the process of “stem cells→ transient amplifying cells→ terminally differentiated cells” [28]. Moreover, we demonstrated that several transcription factors critical for pancreatic progenitor development were also up-regulated in the islets of our P21 overexpression transgenic mice after STZ treatment (Fig.…”

Section: Discussionmentioning

confidence: 77%

P21cip-Overexpression in the Mouse β Cells Leads to the Improved Recovery from Streptozotocin-Induced Diabetes

et al. 2009

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Under normal conditions, the regeneration of mouse β cells is mainly dependent on their own duplication. Although there is evidence that pancreatic progenitor cells exist around duct, whether non-β cells in the islet could also potentially contribute to β cell regeneration in vivo is still controversial. Here, we developed a novel transgenic mouse model to study the pancreatic β cell regeneration, which could specifically inhibit β cell proliferation by overexpressing p21 cip in β cells via regulation of the Tet-on system. We discovered that p21 overexpression could inhibit β-cell duplication in the transgenic mice and these mice would gradually suffer from hyperglycemia. Importantly, the recovery efficiency of the p21-overexpressing mice from streptozotocin-induced diabetes was significantly higher than control mice, which is embodied by better physiological quality and earlier emergence of insulin expressing cells. Furthermore, in the islets of these streptozotocin-treated transgenic mice, we found a large population of proliferating cells which expressed pancreatic duodenal homeobox 1 (PDX1) but not markers of terminally differentiated cells. Transcription factors characteristic of early pancreatic development, such as Nkx2.2 and NeuroD1, and pancreatic progenitor markers, such as Ngn3 and c-Met, could also be detected in these islets. Thus, our work showed for the first time that when β cell self-duplication is repressed by p21 overexpression, the markers for embryonic pancreatic progenitor cells could be detected in islets, which might contribute to the recovery of these transgenic mice from streptozotocin-induced diabetes. These discoveries could be important for exploring new diabetes therapies that directly promote the regeneration of pancreatic progenitors to differentiate into islet β cells in vivo.

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Section: Discussionmentioning

confidence: 77%

P21cip-Overexpression in the Mouse β Cells Leads to the Improved Recovery from Streptozotocin-Induced Diabetes

et al. 2009

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“…22 In 2002, Jarnbring et al studied the number of apoptotic and proliferative gingival keratinocytes in patients with gingivitis and in those with periodontitis with PCNA. [23][24][25][26] Monitoring the expression of PCNA, which is a polymerase-delta helper protein in DNA, provides valuable information about the reparative and regenerative potential of the cell. 10 As previous studies showed, the structure of DNA can be used to observe and evaluate the mitotic activity in the proliferating cell population.…”

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confidence: 99%

Comparison of Keratinocyte Proliferation in Diabetic and Non‐Diabetic Inflamed Gingiva

Açikgoz

Devrim

Özdamar

2004

Journal of Periodontology

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“…[2] [8] When a basal cell divides, both daughter cells may remain on the basement membrane, but an adjacent keratinocyte is displaced into the suprabasal layer and then enters into differentiation.…”

Section: Cell Replicationmentioning

confidence: 99%

“…[8] [14] It has been suggested that the basal keratinocytes with the flatter dermal interface, the so-called non-serrated basal cells, may in fact be stem cells. [3] The stem cells divide, thereby giving rise to transient amplifying cells.…”

Section: Cell Replicationmentioning

confidence: 99%