Advances in the Diagnosis and Treatment of Vasculitis

Amezcua-Guerra, Luís M.

doi:10.5772/1767

Cited by 3 publications

References 436 publications

(547 reference statements)

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Ultrasound Technologies and the Diagnosis of Giant Cell Arteritis

Jianu

Jianu²,

Dan

et al. 2021

Biomedicines

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Giant cell arteritis (GCA) is a primary autoimmune vasculitis that specifically affects medium-sized extracranial arteries, like superficial temporal arteries (TAs). The most important data to be considered for the ultrasound (US) diagnosis of temporal arteritis are stenosis, acute occlusions and “dark halo” sign, which represent the edema of the vascular wall. The vessel wall thickening of large vessels in GCA can be recognized by the US, which has high sensitivity and is facile to use. Ocular complications of GCA are common and consist especially of anterior arterial ischemic optic neuropathies or central retinal artery occlusion with sudden, painless, and sharp loss of vision in the affected eye. Color Doppler imaging of the orbital vessels (showing low-end diastolic velocities and a high resistance index) is essential to quickly differentiate the mechanism of ocular involvement (arteritic versus non-arteritic), since the characteristics of TAs on US do not correspond with ocular involvement on GCA. GCA should be cured immediately with systemic corticosteroids to avoid further visual loss of the eyes.

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Ultrasound Technologies and the Diagnosis of Giant Cell Arteritis

Jianu

Jianu²,

Dan

et al. 2021

Biomedicines

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HSV-Induced Systemic Inflammation as an Animal Model for Behçet’s Disease and Therapeutic Applications

Islam

Sohn

2018

Viruses

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Behçet’s disease (BD) affects multiple organs. It is mainly characterized by recurrent oral, skin, and genital aphthous ulcers, and eye involvement. Successful management of BD is increasing, although its etiology remains unclear. A number of etiologies have been proposed, including environmental, genetic, viral, and immunological factors. To understand its complex etiology and improve its management, animal models of BD have been used to enable more effective therapeutic applications with increased clinical significance. An herpes simplex virus (HSV) type 1-induced BD mouse model has shown disease characteristics similar to those seen in BD patients. An HSV-induced BD animal model has been used to test various therapeutic modalities. The applied modalities are several materials that are derived from natural products, conventional therapeutics, and possible biologics. In this review, we provided how they regulate inflammation in an HSV-induced BD model.

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Intravenous Immunoglobulin Therapy in Primary Vasculitides

Lukan¹

2011

Advances in the Diagnosis and Treatment of Vasculitis

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Advances in the Diagnosis and Treatment of Vasculitis

Cited by 3 publications

References 436 publications

Ultrasound Technologies and the Diagnosis of Giant Cell Arteritis

Ultrasound Technologies and the Diagnosis of Giant Cell Arteritis

HSV-Induced Systemic Inflammation as an Animal Model for Behçet’s Disease and Therapeutic Applications

Intravenous Immunoglobulin Therapy in Primary Vasculitides

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