Advances in the Management of Sickle Cell Disease: New Concepts and Future Horizons

Higgins, Tara; Menditto, Melissa A; Katartzis, Stephanie; Matson, Kelly L.

doi:10.5863/1551-6776-27.3.206

Cited by 4 publications

(2 citation statements)

References 15 publications

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“…However, the precise magnitude of the benefit and the optimal duration of therapy require further investigation. Ongoing research aims to clarify the longterm effects and establish evidence-based guidelines for the use of aspirin to prevent complications in SCD [20,[26][27][28][29].…”

Section: Efficacy and Safety Data In Scd Patientsmentioning

confidence: 99%

The Role of Antiplatelet in the Management of Sickle Cell Disease Patients

Naramreddy,

Varma,

Taksande

et al. 2023

Cureus

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Sickle cell disease (SCD) is a genetic disorder characterized by abnormal hemoglobin, leading to red blood cell deformities and subsequent vaso-occlusive events. Platelet activation and adhesion play a significant role in the pathophysiology of SCD, contributing to the development of complications such as vaso-occlusive events, stroke, acute chest syndrome, and other manifestations. Antiplatelet therapy has emerged as a potential strategy to mitigate these complications by modulating the platelet function and reducing thrombotic events. This review article provides an overview of antiplatelet therapy's role in managing SCD patients. It discusses the pathophysiological abnormalities in the platelet function in SCD, the rationale for antiplatelet therapy, and the evidence supporting its use in various clinical scenarios. The article explores aspirin as the primary antiplatelet agent in SCD, including its mechanism of action, dosing considerations, and efficacy and safety data. Additionally, it highlights other antiplatelet agents, such as clopidogrel, prasugrel, ticagrelor, and emerging therapies under investigation. Clinical applications of antiplatelet therapy in primary and secondary prevention and the management of acute chest syndrome and other SCD complications are also discussed. Safety considerations are emphasized, including bleeding risk assessment, monitoring, and patient selection for antiplatelet therapy. Finally, the review highlights future research and clinical practice directions, including the development of novel antiplatelet agents, combination therapies, and the integration of antiplatelet therapy with other SCD treatments. Overall, this review provides a comprehensive understanding of the current role of antiplatelet therapy in SCD management, the challenges faced, and future directions for improving patient outcomes.

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Section: Efficacy and Safety Data In Scd Patientsmentioning

confidence: 99%

The Role of Antiplatelet in the Management of Sickle Cell Disease Patients

Naramreddy,

Varma,

Taksande

et al. 2023

Cureus

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“…Given the widespread and complex mechanism of action, crizanlizumab may have applications beyond the realm of sickle cell disease [22][23][24]. COVID-19 is characterized by vascular inflammation and thrombosis, including elevations in P-selectin.…”

Section: Crizanlizumabmentioning

confidence: 99%

Novel Strategies for the Treatment of COVID-19

McCarthy

2022

Drugs R D

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On 4 September, 2020, the US National Institutes of Health launched a new clinical trial, “A Multicenter, Adaptive, Randomized Controlled Platform Trial of the Safety and Efficacy of Antithrombotic and Additional Strategies in Hospitalized Adults with COVID-19.” This open-label, placebo-controlled, multicenter, adaptive platform study was designed to evaluate therapeutic options for patients hospitalized with mild, moderate, or severe COVID-19. A variety of drugs and drug classes were selected, including heparin, the monoclonal antibody crizanlizumab, sodium-glucose cotransporter-2 inhibitors, and purinergic signaling receptor Y 12 inhibitors. These medications have been widely used in the treatment of other conditions, from sick cell disease to type 2 diabetes mellitus and some forms of cardiovascular disease, but their inclusion in a study of COVID-19 was somewhat unexpected. This article examines the rationale behind the use of these disparate agents in the treatment and prevention of adverse outcomes in patients with COVID-19 and explores how these strategies may be utilized in the future to address the severe acute respiratory syndrome coronavirus 2 pandemic.

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Sickle Cell Disease (SCD) and Perioperative Pain Management

Iradukunda

2024

Perioperative Pain Management

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Advances in the Management of Sickle Cell Disease: New Concepts and Future Horizons

Cited by 4 publications

References 15 publications

The Role of Antiplatelet in the Management of Sickle Cell Disease Patients

The Role of Antiplatelet in the Management of Sickle Cell Disease Patients

Novel Strategies for the Treatment of COVID-19

Sickle Cell Disease (SCD) and Perioperative Pain Management

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