Advances in tick vaccinology in Brazil  from gene expression to immunoprotection

Andreotti, Renato; Giachetto, P. F.; Cunha, Rodrigo Casquero

doi:10.2741/s504

Cited by 6 publications

(2 citation statements)

References 58 publications

(72 reference statements)

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“…Single cell and related technologies that allow sequencing of minute quantities of genetic material may open up the possibility of sequencing larval or nymphal glands made accessible via laser microdissection. This will certainly advance tick salivary gland transcriptomics, since differential expression between life stages is well-recognized (Schwarz et al, 2013 ; Andreotti et al, 2018 ).…”

Section: Future Perspectives On Salivary Gland Complexitymentioning

confidence: 97%

Quantitative Visions of Reality at the Tick-Host Interface: Biochemistry, Genomics, Proteomics, and Transcriptomics as Measures of Complete Inventories of the Tick Sialoverse

Mans

2020

Front. Cell. Infect. Microbiol.

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Species have definitive genomes. Even so, the transcriptional and translational products of the genome are dynamic and subject to change over time. This is especially true for the proteins secreted by ticks at the tick-host feeding interface that represent a complex system known as the sialoverse. The sialoverse represent all of the proteins derived from tick salivary glands for all tick species that may be involved in tick-host interaction and the modulation of the host's defense mechanisms. The current study contemplates the advances made over time to understand and describe the complexity present in the sialoverse. Technological advances at given periods in time allowed detection of functions, genes, and proteins enabling a deeper insight into the complexity of the sialoverse and a concomitant expansion in complexity with as yet, no end in sight. The importance of systematic classification of the sialoverse is highlighted with the realization that our coverage of transcriptome and proteome space remains incomplete, but that complete descriptions may be possible in the future. Even so, analysis and integration of the sialoverse into a comprehensive understanding of tick-host interactions may require further technological advances given the high level of expected complexity that remains to be uncovered.

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Section: Future Perspectives On Salivary Gland Complexitymentioning

confidence: 97%

Quantitative Visions of Reality at the Tick-Host Interface: Biochemistry, Genomics, Proteomics, and Transcriptomics as Measures of Complete Inventories of the Tick Sialoverse

Mans

2020

Front. Cell. Infect. Microbiol.

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“…In the field of veterinary vaccinology, the reverse vaccinology approach is being applied, for instance, to organisms like cattle neosporosis ( 67 , 68 ), Rhipicephalus microplus ( 69 – 71 ), Ehrlichia ruminantium ( 72 , 73 ), and bovine herpesvirus 4 ( 74 ).…”

Section: Vaccine Discovery and Design: The Role Of Big Datamentioning

confidence: 99%

Vaccines Meet Big Data: State-of-the-Art and Future Prospects. From the Classical 3Is (“Isolate–Inactivate–Inject”) Vaccinology 1.0 to Vaccinology 3.0, Vaccinomics, and Beyond: A Historical Overview

Bragazzi

Gianfredi

Villarini

et al. 2018

Front. Public Health

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Vaccines are public health interventions aimed at preventing infections-related mortality, morbidity, and disability. While vaccines have been successfully designed for those infectious diseases preventable by preexisting neutralizing specific antibodies, for other communicable diseases, additional immunological mechanisms should be elicited to achieve a full protection. “New vaccines” are particularly urgent in the nowadays society, in which economic growth, globalization, and immigration are leading to the emergence/reemergence of old and new infectious agents at the animal–human interface. Conventional vaccinology (the so-called “vaccinology 1.0”) was officially born in 1796 thanks to the contribution of Edward Jenner. Entering the twenty-first century, vaccinology has shifted from a classical discipline in which serendipity and the Pasteurian principle of the three Is (isolate, inactivate, and inject) played a major role to a science, characterized by a rational design and plan (“vaccinology 3.0”). This shift has been possible thanks to Big Data, characterized by different dimensions, such as high volume, velocity, and variety of data. Big Data sources include new cutting-edge, high-throughput technologies, electronic registries, social media, and social networks, among others. The current mini-review aims at exploring the potential roles as well as pitfalls and challenges of Big Data in shaping the future vaccinology, moving toward a tailored and personalized vaccine design and administration.

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Inhibition of energy metabolism by 3-bromopyruvate in the hard tick Rhipicephalus microplus

Braz

Gomes

Galina

et al. 2019

Comparative Biochemistry and Physiology Part C: Toxicology &

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Advances in tick vaccinology in Brazil from gene expression to immunoprotection

Cited by 6 publications

References 58 publications

Quantitative Visions of Reality at the Tick-Host Interface: Biochemistry, Genomics, Proteomics, and Transcriptomics as Measures of Complete Inventories of the Tick Sialoverse

Quantitative Visions of Reality at the Tick-Host Interface: Biochemistry, Genomics, Proteomics, and Transcriptomics as Measures of Complete Inventories of the Tick Sialoverse

Vaccines Meet Big Data: State-of-the-Art and Future Prospects. From the Classical 3Is (“Isolate–Inactivate–Inject”) Vaccinology 1.0 to Vaccinology 3.0, Vaccinomics, and Beyond: A Historical Overview

Inhibition of energy metabolism by 3-bromopyruvate in the hard tick Rhipicephalus microplus

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