Advances in Tissue Engineering and Regeneration

Ghosal, Krishanu; Sarkar, Priyatosh; Saha, Rima; Ghosh, Santanu

doi:10.1007/978-3-030-34471-9_22

Cited by 4 publications

(2 citation statements)

References 347 publications

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“…Upon the requirements of combining basic (chemistry, physics, engineering) and life sciences (biology, medicine), this constructive step is still a challenging task. 3 Typical materials used for the fabrication of tissue engineering scaffolds include synthetic and natural polymers, 4–10 metals, 11–13 ceramics, 14,15 and their combinations. However, a novel approach assumes the creation of advanced bioactive materials that serve as crucial support structures in TE.…”

Section: Introductionmentioning

confidence: 99%

Deep eutectic solvent-assisted fabrication of bioinspired 3D carbon–calcium phosphate scaffolds for bone tissue engineering

et al. 2023

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Section: Introductionmentioning

confidence: 99%

Deep eutectic solvent-assisted fabrication of bioinspired 3D carbon–calcium phosphate scaffolds for bone tissue engineering

et al. 2023

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“…The third and final one is the growth factor, which catalyzes differentiation and proliferation of cells. For successful tissue regeneration, biomaterials play a very crucial role as they support cell adhesion, proliferation, and ultimately ECM formation . A suitable biomaterial for tissue engineering applications should be nontoxic and biodegradable in nature with sufficient porosity so that cells can easily proliferate and differentiate within it, as well as possess enough mechanical properties so it can mimic the host tissue properties. − To date, a wide range of biomaterials have been exploited for tissue engineering applications which include metals, , ceramics, , composites, , and polymers.…”

Section: Introductionmentioning

confidence: 99%

Green Synthesis of Nonisocyanate Poly(ester urethanes) from Renewable Resources and Recycled Poly(ethylene terephthalate) Waste for Tissue Engineering Application

Ghosal,

Sarkar,

Chakraborty

et al. 2023

ACS Sustainable Chem. Eng.

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Since the remarkable discovery of polyurethanes (PU), significant progress has been made in their synthesis and processing, expanding their applications across various fields. However, the inclusion of isocyanates and the utilization of toxic catalysts for PU synthesis impose a significant challenge for their biomedical application. In this study, we present a novel approach: an isocyanate and catalyst-free melt polycondensation process for the preparation of a series of poly(ester urethanes). To synthesize the poly(ester urethanes), we have employed a combination of poly(ethylene terephthalate) (PET) waste-derived monomers and a diverse range of renewable resources, including oleic acid, ethylene carbonate, citric acid, sebacic acid, and mannitol. The synthesis of the poly(ester urethanes) was confirmed by FTIR spectroscopy and 1 H NMR spectroscopy, while the physicochemical properties of the poly(ester urethanes) were investigated using XRD, TGA, DSC, and UTM. The thermal characteristics, mechanical properties, and biodegradation behavior of the poly(ester urethanes) can be adjusted by simply changing the PET waste-derived diols. The mechanical characteristics of the synthesized poly(ester urethanes) closely resemble those of various soft tissues found in the human body, including articular cartilage, cervical spinal components, ligaments, aorta, and soft collagenous bone, indicating its promising potential for soft tissue engineering applications. In addition to that, the synthesized poly(ester urethanes) exhibited excellent shape memory behavior, along with a good recovery response at ambient temperature. Furthermore, the synthesized poly(ester urethanes) demonstrated certain levels of antimicrobial activity, exceptional in vitro cytocompatibility, and cell proliferation against mouse fibroblast cells (NIH/3T3) as confirmed by alamar blue and live/dead assays suggesting its potential soft tissue engineering applications.

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Recent Advances in Regenerative Tissue Fabrication: Tools, Materials, and Microenvironment in Hierarchical Aspects

Ratri

Brilian

Setiawati

et al. 2021

Advanced NanoBiomed Research

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As part of regenerative medicine, artificial, hierarchical tissue engineering is a favorable approach to satisfy the needs of patients for new tissues and organs to replace those with defects caused by age, disease, or trauma or to correct congenital disabilities. However, the application of tissue engineering faces critical issues, such as the biocompatibility of the fabricated tissues and organs, the scaffolding, the complex biomechanical processes within cells, and the regulation of cell biology. Although fabrication strategies, including the traditional bioprinting, photolithography, and organ‐on‐a‐chip methods, as well as combinations of fabrication processes, face many challenges, they are methods that can be used in hierarchical tissue engineering. The strategic approach to synthetic, hierarchical tissue engineering is to use a combination of several technologies incorporating material science, cell biology, additive manufacturing (AM), on‐a‐chip strategies, and biomechanics. Herein, in a review, the current materials and biofabrication strategies of various artificial hierarchical tissues are discussed based on the level of tissue complexity from nano to macrosize and the adaptive interactions between cells and the scaffolding surrounding the incorporated cells.

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Advances in Tissue Engineering and Regeneration

Cited by 4 publications

References 347 publications

Deep eutectic solvent-assisted fabrication of bioinspired 3D carbon–calcium phosphate scaffolds for bone tissue engineering

Deep eutectic solvent-assisted fabrication of bioinspired 3D carbon–calcium phosphate scaffolds for bone tissue engineering

Green Synthesis of Nonisocyanate Poly(ester urethanes) from Renewable Resources and Recycled Poly(ethylene terephthalate) Waste for Tissue Engineering Application

Recent Advances in Regenerative Tissue Fabrication: Tools, Materials, and Microenvironment in Hierarchical Aspects

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