Advances on ultra-sensitive electrospun nanostructured electrochemical and colorimetric sensors for diabetes mellitus detection

Hussain, Mohamed Hasaan; Fook, Lim Ping; Putri, Maria Kana Sanira; Tan, Huey Ling; Bakar, Noor Fitrah Abu; Radacsi, Norbert

doi:10.1016/j.nanoms.2021.05.001

Cited by 27 publications

(8 citation statements)

References 159 publications

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“…The colorimetric wearable sensor could reveal subtle differences about the glucose concentrations in sweat. However, in the colorimetric analysis of perspiration glucose, it is necessary to take into account the potential chemical harm caused by the contact of colorimetric reagents and reaction products with the skin during sampling and perception [62,129]. The microfluidicbased wearable device studied by the authors was designed to keep the sampling process sealed to avoid evaporation and contamination of the sweat samples.…”

Section: Glucosementioning

confidence: 99%

Wearable Sensor for Continuous Sweat Biomarker Monitoring

Qiao

Chen

et al. 2022

Chemosensors

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In recent years, wearable sensors have enabled the unique mode of real-time and noninvasive monitoring to develop rapidly in medical care, sports, and other fields. Sweat contains a wide range of biomarkers such as metabolites, electrolytes, and various hormones. Combined with wearable technology, sweat can reflect human fatigue, disease, mental stress, dehydration, and so on. This paper comprehensively describes the analysis of sweat components such as glucose, lactic acid, electrolytes, pH, cortisol, vitamins, ethanol, and drugs by wearable sensing technology, and the application of sweat wearable devices in glasses, patches, fabrics, tattoos, and paper. The development trend of sweat wearable devices is prospected. It is believed that if the sweat collection, air permeability, biocompatibility, sensing array construction, continuous monitoring, self-healing technology, power consumption, real-time data transmission, specific recognition, and other problems of the wearable sweat sensor are solved, we can provide the wearer with important information about their health level in the true sense.

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Section: Glucosementioning

confidence: 99%

Wearable Sensor for Continuous Sweat Biomarker Monitoring

Qiao

Chen

et al. 2022

Chemosensors

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“… 123 , 131 , 133 Moreover, some changes in the electrospinning system, in particular the spinning needle system, make it possible to obtain core–shell, 136 side-by-side, 137 hollow, twisted, or multilayer structures. 123 , 125 − 127 The electrospun fibers find many applications in the medical field, such as protective face masks, 1 , 2 tissue engineering, 25 , 138 especially for bone 139 with controlled fibers’ surface potential 140 , 141 and geometry, 142 , 143 wound dressing, vascular grafts, 144 heart valves, 145 skin patches, 146 − 148 sensors, 149 and many more. 150 − 152 …”

Section: Electrospinning Of Pha Polymersmentioning

confidence: 99%

“…A potential difference is created between the needle and the collector. The electric field causes the polymer jet to be dynamically drawn, while solvent evaporates and solid fibers are produced. ,,, Numerous experimental studies confirm that the morphology of the fibers obtained depends mainly on the process parameters as well as on the composition of the polymer solution, ,,, applied voltage polarity, ,− ,, flow rate of the polymer, ,,, humidity ,,, and temperature during the process, ,, and distance between the needle tip and the collector. ,, Moreover, some changes in the electrospinning system, in particular the spinning needle system, make it possible to obtain core–shell, side-by-side, hollow, twisted, or multilayer structures. ,− The electrospun fibers find many applications in the medical field, such as protective face masks, , tissue engineering, , especially for bone with controlled fibers’ surface potential , and geometry, , wound dressing, vascular grafts, heart valves, skin patches, − sensors, and many more. − …”

Section: Electrospinning Of Pha Polymersmentioning

confidence: 99%

Development and Advantages of Biodegradable PHA Polymers Based on Electrospun PHBV Fibers for Tissue Engineering and Other Biomedical Applications

Kaniuk

Stachewicz

2021

ACS Biomater. Sci. Eng.

112

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Biodegradable polymeric biomaterials offer a significant advantage in disposable or fast-consuming products in medical applications. Poly(3-hydroxybutyrate- co -3-hydroxyvalerate) (PHBV) is an example of a polyhydroxyalkanoate (PHA), i.e., one group of natural polyesters that are byproducts of reactions taking place in microorganisms in conditions with an excess carbon source. PHA polymers are a promising material for the production of everyday materials and biomedical applications. Due to the high number of monomers in the group, PHAs permit modifications enabling the production of copolymers of different compositions and with different proportions of individual monomers. In order to change and improve the properties of polymer fibers, PHAs are combined with either other natural and synthetic polymers or additives of inorganic phases. Importantly, electrospun PHBV fibers and mats showed an enormous potential in both the medical field (tissue engineering scaffolds, plasters, wound healing, drug delivery systems) and industrial applications (filter systems, food packaging). This Review summarizes the current state of the art in processing PHBV, especially by electrospinning, its degradation processes, and biocompatibility studies, starting from a general introduction to the PHA group of polymers.

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“…To date, thanks to the recent developments in nanochemistry and nanomaterial engineering science, which allow multifunctional nanomaterials to be utilized in various application areas, including environmental [ 30 ], food [ 31 ], energy [ 32 , 33 ], biomedical [ 34 ], etc., combinations of nanomaterials and nanocomposites with MIPs are very popular and have already been introduced to solve poor binding and template leakage problems. Therefore, several aspects can be modified during a sensor design to improve the selectivity and sensitivity, such as the size and shape.…”

Section: Introductionmentioning

confidence: 99%

Electrochemical Sensing of Favipiravir with an Innovative Water-Dispersible Molecularly Imprinted Polymer Based on the Bimetallic Metal-Organic Framework: Comparison of Morphological Effects

2022

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Molecularly imprinted polymers (MIPs) are widely used as modifiers in electrochemical sensors due to their high sensitivity and promise of inexpensive mass manufacturing. Here, we propose and demonstrate a novel MIP-sensor that can measure the electrochemical activity of favipiravir (FAV) as an antiviral drug, thereby enabling quantification of the concentration of FAV in biological and river water samples and in real-time. MOF nanoparticles’ application with various shapes to determine FAV at nanomolar concentrations was described. Two different MOF nanoparticle shapes (dodecahedron and sheets) were systematically compared to evaluate the electrochemical performance of FAV. After carefully examining two different morphologies of MIP-Co-Ni@MOF, the nanosheet form showed a higher performance and efficiency than the nanododecahedron. When MIP-Co/Ni@MOF-based and NIP-Co/Ni@MOF electrodes (nanosheets) were used instead, the minimum target concentrations detected were 7.5 × 10−11 (MIP-Co-Ni@MOF) and 8.17 × 10−9 M (NIP-Co-Ni@MOF), respectively. This is a significant improvement (>102), which is assigned to the large active surface area and high fraction of surface atoms, increasing the amount of greater analyte adsorption during binding. Therefore, water-dispersible MIP-Co-Ni@MOF nanosheets were successfully applied for trace-level determination of FAV in biological and water samples. Our findings seem to provide useful guidance in the molecularly imprinted polymer design of MOF-based materials to help establish quantitative rules in designing MOF-based sensors for point of care (POC) systems.

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Advances on ultra-sensitive electrospun nanostructured electrochemical and colorimetric sensors for diabetes mellitus detection

Cited by 27 publications

References 159 publications

Wearable Sensor for Continuous Sweat Biomarker Monitoring

Wearable Sensor for Continuous Sweat Biomarker Monitoring

Development and Advantages of Biodegradable PHA Polymers Based on Electrospun PHBV Fibers for Tissue Engineering and Other Biomedical Applications

Electrochemical Sensing of Favipiravir with an Innovative Water-Dispersible Molecularly Imprinted Polymer Based on the Bimetallic Metal-Organic Framework: Comparison of Morphological Effects

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