Adverse drug reactions of nonsteroidal antiinflammatory drugs in orthopedic patients

Abstract

Objectives:To identify the ADRs due to NSAIDs and to know how to monitor the drug’s effect.Materials and Methods:A descriptive study was undertaken in the Orthopedic Outpatients Department of a tertiary care teaching hospital. Hundred patients were enrolled in this study to observe the risk of adverse drug reactions (ADRs) due to NSAIDs. All the ADRs were further analyzed in relation to age and sex, type of drug and its pattern. Probability scale was used for the causality assessment of the ADRs.Results:26% of the 100 patients developed ADR due to NSAIDs. There was not much of a difference in the number of the ADRs in relation to the gender. Diclofenac was the highest prescribed drug (65 patients), followed by paracetamol (12), nimesulide (10), ibuprofen (6), piroxicam (5) and Etoricoxib (2). Diclofenac accounted for the maximum number (73%) of ADRs, followed by nimesulide (16%), paracetamol (7%), and Etoricoxib (4%).Conclusion:Pharmacovigilance improves recognition of ADRs by the medical students. It allows the treating physician to identify the ADR associated with drugs, in particular, with the ones considered relatively safe and with those commonly prescribed by the medical and non-health professionals.

Content Analysis of Single-dose Analgesics Dispensed by Attendants in Retail Drug Outlets in Obiaruku ,Delta State , Nigeria : A Surrogate-type Approach

“…This is of serious concern as the risk of gastrointestinal erosion and hemorrhage increases even further with the concomitant use of NSAIDs and corticosteroids. [27] Also drugs such as vitamin B complex (2, 10.5%), cod liver oil, Sulpfadoxine-pyrimetamine, Salbutamol and Ferrous sulphate (1, 5.3%) and multivitamin (12, 63.2%) not indicated for analgesia were found to be included in some of the single doses. This gross irrational combination of drugs may be indicative of the fact that shop attendants in the community pharmacies and PMSs in this study area lack the basic concept of pain and its pharmacological management.…”

Power Point Therapy: An Effective and Simple Treatment for Subacute Back Pain – A Randomized Controlled Trial

“…Hence, it has to be considered superior to other types of treatments that need more complicated, time-consuming, and expensive procedures. Considering the fact that pharmacological treatments for chronic pain are discouraged by practically all guidelines because of either potential side effects, as with NSAIDs [50], or the potential for dependence with other substances [51, 52], uncomplicated alternatives such as PPT are most welcome. Our data show that PPT is effective and uncomplicated, as we had no dropouts due to adverse events or other complications.…”

Utilization Pattern of Non-steroidal Anti-inflammatory Drugs at a Primary Health Care in Malaysia

“…However, the reason may be because, it has been established that continuous therapy for a long time more than 28 days, may put the patient at a higher risk of ADR, drug-interaction and medication non-adherence. 5,8 In many reported cases, the gastrointestinal (GI) complications related to NSAIDs use was four times higher when compared to non-users. 9,10 Furthermore, findings of the current study has also indicated that patients on medications for management of chronic underlying illness are among the frequent users of NSAIDs.…”

“…Despite the widespread utilization and effectivenesss, the use of NSAIDs is associated with adverse drug reactions (ADR) such as gastro-intestinal (GI) complications, leading to hospitalization and deterioration of disease conditions. 4,5 A report has shown that, Diclofenac Sodium, a sub-class of NSAIDs was among the top three drugs most commonly implicated in ADR based on the Malaysian Adverse Drug reaction Advisory Committee (MADRAC) report in 2008.r. Another study has indi-cated that the risk of serious GI complications in NSAID's users is almost four times higher than nonusers.…”