Adverse Reactions With Oral and Parenteral Gold Preparations

Tozman, Elaine C.; Gottlieb, Norman L.

doi:10.1007/bf03259863

Cited by 36 publications

(8 citation statements)

References 75 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Both parenterally and perorally administered gold compounds can give rise to pronounced nephrotoxicity, and careful monitoring is therefore needed when administering the traditional gold compounds (Hashimoto et al 1992;Tozman and Gottlieb 1987;Felson et al 1990;Merchant 1998). Gold thio salts have only occasionally been suggested to cause neurotoxicity, most likely because the blood-brain barrier seems to exclude gold ions from the CNS.…”

mentioning

confidence: 98%

Effects of dissolucytotic gold ions on recovering brain lesions

Danscher

2010

Histochem Cell Biol

View full text Add to dashboard Cite

show abstract

mentioning

confidence: 98%

Effects of dissolucytotic gold ions on recovering brain lesions

Danscher

2010

Histochem Cell Biol

View full text Add to dashboard Cite

show abstract

“…Gold medication may lead to a variety of side effects including mucocutaneous, haematological, renal, pulmonary, gastrointestinal, ocular and other disorders. [2][3][4][5] The frequency of these side-effects has varied in different investigations and about 30-60% of those treated with gold compounds have experienced one or more adverse effects. 3,[5][6][7][8][9] In an analysis where the frequency of cutaneous side-effects was correlated with the frequency of use, gold compounds were found to be the most common inducers of untoward reactions.…”

mentioning

confidence: 99%

Hypersensitivity to gold in gold sodium thiomalate-induced dermatosis

Räsänen¹,

Kaipiainen‐Seppänen²,

Myllykangas-Luosujärvi³

et al. 1999

British Journal of Dermatology

View full text Add to dashboard Cite

Gold compounds are widely used in the treatment of rheumatoid arthritis. Mucocutaneous side-effects leading to the discontinuation of medication are common with these drugs. We investigated whether allergic mechanisms are involved in dermatosis induced by gold sodium thiomalate (GSTM). Thirteen gold dermatosis patients, 15 arthritis patients without any side-effects from GSTM and 11 healthy controls participated in the study. Venous blood lymphocytes from these subjects were cultured with GSTM and gold sodium thiosulphate (GSTS) in the lymphocyte proliferation test (LPT). In some cases, interferon-gamma-producing cells were enumerated in vitro (T-cell ELISpot). The subjects were also patch-tested with GSTM and GSTS. The LPT to either GSTM, GSTS or both was positive in 12 of 13 patients with gold dermatosis. In the arthritis patient group without side-effects from gold, the LPT gave two false-positive results and in the healthy control group the LPT was falsely positive with one subject. T-cell ELISpot was positive in four of six gold dermatosis patients and negative in the arthritis and healthy control groups. Only one patient who also developed contact dermatitis from gold jewellery was positive to gold in the patch test. These results indicate that gold dermatosis is mediated, at least in part, by allergic mechanisms and that the LPT is of value in the diagnosis of gold dermatosis.

show abstract

“…The use of gold compounds in medicine has however been limited due to adverse eVects. Both parenterally and perorally administered gold compounds can cause pronounced nephrotoxicity and careful monitoring is needed when administering the traditional gold compounds (Tozman and Gottlieb 1987;Felson et al 1990). These toxic eVects can be by-passed by using local application of metallic gold particles/implants.…”

Section: Introductionmentioning

confidence: 98%

Gold ions bio-released from metallic gold particles reduce inflammation and apoptosis and increase the regenerative responses in focal brain injury

Kolind

Pedersen

Doering

et al. 2008

Histochem Cell Biol

View full text Add to dashboard Cite

Traumatic brain injury results in loss of neurons caused as much by the resulting neuroinflammation as by the injury. Gold salts are known to be immunosuppressive, but their use are limited by nephrotoxicity. However, as we have proven that implants of pure metallic gold release gold ions which do not spread in the body, but are taken up by cells near the implant, we hypothesize that metallic gold could reduce local neuroinflammation in a safe way. Bio-liberation, or dissolucytosis, of gold ions from metallic gold surfaces requires the presence of disolycytes i.e. macrophages and the process is limited by their number and activity. We injected 20-45 mum gold particles into the neocortex of mice before generating a cryo-injury. Comparing gold-treated and untreated cryolesions, the release of gold reduced microgliosis and neuronal apoptosis accompanied by a transient astrogliosis and an increased neural stem cell response. We conclude that bio-liberated gold ions possess pronounced anti-inflammatory and neuron-protective capacities in the brain and suggest that metallic gold has clinical potentials. Intra-cerebral application of metallic gold as a pharmaceutical source of gold ions represents a completely new medical concept that bypasses the blood-brain-barrier and allows direct drug delivery to inflamed brain tissue.

show abstract

Adverse Reactions With Oral and Parenteral Gold Preparations

Cited by 36 publications

References 75 publications

Effects of dissolucytotic gold ions on recovering brain lesions

Effects of dissolucytotic gold ions on recovering brain lesions

Hypersensitivity to gold in gold sodium thiomalate-induced dermatosis

Gold ions bio-released from metallic gold particles reduce inflammation and apoptosis and increase the regenerative responses in focal brain injury

Contact Info

Product

Resources

About