Aerobic exercise effects upon cognition in Alzheimer’s Disease: A systematic review of randomized controlled trials

Cammisuli, Davide Maria; Innocenti, Augusto; Fusi, Jonathan; Franzoni, Ferdinando; Pruneti, Carlo

doi:10.12871/00039829201816

Cited by 20 publications

(15 citation statements)

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“…There seems to be growing evidence for a slowing in the decline of cognitive function with exercise interventions in people with dementia (Bowes et al, 2013;Brett et al, 2016;Cammisuli et al, 2018;Du et al, 2018;Groot et al, 2016;Herná ndez et al, 2015), but that conclusion is not universal. Forbes et al (2015) claim there is no clear evidence of benefits on cognitive functioning from exercise, and describe the evidence as of very low quality, while Littbrand et al (2011) state that the role of exercise on cognition is unclear either because of the quality of the studies, or because the intensity was too low.…”

Section: Resultsmentioning

confidence: 99%

“…Forbes et al (2015) claim there is no clear evidence of benefits on cognitive functioning from exercise, and describe the evidence as of very low quality, while Littbrand et al (2011) state that the role of exercise on cognition is unclear either because of the quality of the studies, or because the intensity was too low. Cammisuli et al (2018) in a narrative review on AD patients found that exercise may improve global functioning (in particular in the mild-moderate phase) but they could not conclude it definitely promotes a positive effect upon cognition, because of limitations of the tests of cognition used in the studies: nevertheless, they still recommend prescribing exercise to sedentary patients at the early stages to prevent cognitive deterioration. Similarly, Du et al's (2018) review of AD patients suggests exercise may prevent cognitive deterioration, but RCT's with "clear intervention criteria, large samples and long term follow up are needed".…”

Section: Resultsmentioning

confidence: 99%

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Exercise and dementia: what should we be recommending?

Lewis

Livsey

Naughton

et al. 2020

QAOA

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Purpose Exercise has the potential to provide benefits for people living with dementia, yet the balance of evidence is uncertain. This paper aims to provide an evidence synthesis to determine whether exercise improves their health and well-being and what exercise should be recommended. Design/methodology/approach Structured search for existing literature reviews on exercise for dementia. Relevant articles were selected and critically appraised against systematic criteria. The findings from 15 high quality reviews were collated by using a best evidence synthesis approach. Findings The evidence is convincing for improving physical health, promising for cognitive benefits, mixed for psychological benefits and limited for behavioural outcomes. No evidence of harm was found. Overall, exercise can improve physical and mental health for people living with dementia: there is sufficient evidence to recommend multimodal exercise. Social implications The potential beneficial outcomes are of significant importance both for people with dementia and their caregivers. In the absence of more specific findings, the current recommendation for older adults in general is pragmatically justified – some activity is better than none, more activity provides greater benefits. Adding social interaction may be important for psychological and behavioural outcomes. Originality/value To the best of the authors’ knowledge, this paper is the first to encapsulate the literature to date on exercise for dementia. Combining the findings from previous reviews enabled a novel synthesis across the range of relevant interventions and outcomes.

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Exercise and dementia: what should we be recommending?

Lewis

Livsey

Naughton

et al. 2020

QAOA

View full text Add to dashboard Cite

show abstract

“…Therefore, standardized protocols and larger and more detailed randomized controlled clinical trials with long-term follow-up are required to provide a better insight into the effects of physical exercise on cognitive function (45)(46)(47).…”

Section: Beneficial Effects Of Physical Exercisementioning

confidence: 99%

Interaction between physical exercise and APOE gene polymorphism on cognitive function in older people

Colovati

Novais

Zampol

et al. 2021

Braz J Med Biol Res

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We aimed to present an overview of the literature regarding the interaction between physical exercise and APOE gene polymorphism on cognitive function, particularly in patients with Alzheimer's disease (AD). Firstly, this review focused on the effect of the physical exercise on cognitive function, regardless of APOE gene polymorphism. Some studies have shown that a high level of cardiorespiratory fitness is associated with less neuronal damage with an improvement in memory score tests whereas other studies failed to detect any association between physical exercise and cognitive improvement either in healthy individuals or patients with AD. Taken together, standardized protocols and more longitudinal studies are required to provide a better insight into the effects of physical exercise on cognitive function. Although there is no agreement in the literature regarding the effects of physical exercise on cognitive function, it is well established that it improves social interaction and the feeling of well-being, thereby positively contributing to the quality of life of the elderly. Regarding the influence of physical exercise on cognitive function in APOE ε4 allele carriers, the data trend shows that the carriers of allele ε4 for APOE gene were more responsive to the beneficial effects of physical exercise on cognitive function compared with non-carriers. Nevertheless, studies with larger sample sizes will provide more accuracy about this relationship.

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“…According to the literature retrieval and screening process of PRISMA (2020) ( Page et al, 2021 ; Figure 1 ), in addition to 21 studies in previously reported systematic reviews ( Cammisuli et al, 2018 ; Du et al, 2018 ; Liang et al, 2018 ; Jia et al, 2019 ), this study updated 7 related articles ( Table 1 ), two of which were retrieved from CNKI database of China. All included literature were provided as Supplementary Data Sheet 1 .…”

Section: Resultsmentioning

confidence: 99%

Effectiveness of Physical Activity Interventions on Cognition, Neuropsychiatric Symptoms, and Quality of Life of Alzheimer’s Disease: An Update of a Systematic Review and Meta-Analysis

Liang

Sheng

et al. 2022

Front. Aging Neurosci.

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The topic of physical activity interventions for the treatment of Alzheimer’s disease (AD) has been discussed for decades, but there are still inconsistent views on the effect of its intervention in different studies. With the increase in randomized controlled trials (RCTs), it is necessary to update newly published studies and systematically evaluate the effects of physical activity interventions. Scientific citation databases (e.g., PubMed, EMBASE, etc.) and registration databases (e.g., ISRCTN, CHICTR, etc.) were checked to screen RCTs and systematic reviews of physical activity interventions in AD. Then extract and review the intervention methods and their evaluation results in the included studies. Spearman correlation method was used to test the association between the mean difference (MD) of intervention results and activity time. The Hedges’g method was used to combine continuous data to analyze the standard MD (SMD) of different intervention types or time subgroups. The overall results show that physical activity intervention can improve the cognition, neuropsychiatric symptoms and quality of life (Qol) of AD patients, but the duration of the intervention significantly affected the outcome of the assessment. Subgroup analysis results showed that an intervention duration of 2–5 months had a significant advantage: cognitive function (Minimum Mental State Examination: SMD = 0.47, 95% CI = 0.33 ∼ 0.61, P < 0.01), neuropsychiatric symptoms (Neuropsychiatric Inventory: SMD = −0.48, 95% CI = −0.85 ∼−0.11, P < 0.01), and quality of life (Qol-AD: SMD = 0.47, 95% CI = 0.23 ∼ 0.71, P < 0.01). The systematic review and analysis results of updated RCTs suggested that short-term (2–5 months) physical activity interventions were more beneficial in improving cognitive function, neuropsychiatric symptoms and Qol in patients with AD. And there was no evidence of differences in the effectiveness of different physical activity interventions.

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Aerobic exercise effects upon cognition in Alzheimer’s Disease: A systematic review of randomized controlled trials

Cited by 20 publications

References 0 publications

Exercise and dementia: what should we be recommending?

Exercise and dementia: what should we be recommending?

Interaction between physical exercise and APOE gene polymorphism on cognitive function in older people

Effectiveness of Physical Activity Interventions on Cognition, Neuropsychiatric Symptoms, and Quality of Life of Alzheimer’s Disease: An Update of a Systematic Review and Meta-Analysis

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