“Aerogels of enzymatically oxidized galactomannans from leguminous plants: Versatile delivery systems of antimicrobial peptides and enzymes”

Campia, Paola; Ponzini, Erika; Rossi, Bianca; Farris, Stefano; Silvetti, Tiziana; Merlini, Luca; Brasca, Milena; Grandori, Rita; Galante, Yves M.

doi:10.1016/j.carbpol.2016.11.089

Cited by 25 publications

(8 citation statements)

References 68 publications

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“…The laccase/TEMPO-mediated grafting of silk fibroin onto bacterial cellulose was shown to enhance the biocompatibility of the membrane [174]. The laccase/TEMPO oxidation of galactomannans led to the production of an aerogel with satisfactory drug delivery properties [175]. Similar materials were also obtained by the laccase oxidation of fenugreek gum [176].…”

Section: Nanobiotechnology and Biomedicinementioning

confidence: 99%

Applications of Microbial Laccases: Patent Review of the Past Decade (2009–2019)

et al. 2019

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There is a high number of well characterized, commercially available laccases with different redox potentials and low substrate specificity, which in turn makes them attractive for a vast array of biotechnological applications. Laccases operate as batteries, storing electrons from individual substrate oxidation reactions to reduce molecular oxygen, releasing water as the only by-product. Due to society’s increasing environmental awareness and the global intensification of bio-based economies, the biotechnological industry is also expanding. Enzymes such as laccases are seen as a better alternative for use in the wood, paper, textile, and food industries, and they are being applied as biocatalysts, biosensors, and biofuel cells. Almost 140 years from the first description of laccase, industrial implementations of these enzymes still remain scarce in comparison to their potential, which is mostly due to high production costs and the limited control of the enzymatic reaction side product(s). This review summarizes the laccase applications in the last decade, focusing on the published patents during this period.

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Section: Nanobiotechnology and Biomedicinementioning

confidence: 99%

Applications of Microbial Laccases: Patent Review of the Past Decade (2009–2019)

et al. 2019

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“…In comparison to other approaches, the use of laccases for the reoxidation of TEMPO proved to be very mild and, promoting a lower degree of oxidations, resulted in the formation of soft gels. The properties of these materials, specifically those obtained by the LMS oxidation of guar polygalactomannanes, was recently investigated by Galante and coworkers and reported in a series of publications [61][62][63][64][65][66][67].…”

Section: Laccase-mediator Systems: From Alcohols Bio-oxidation To Integrated Chemoenzymatic Systemsmentioning

confidence: 99%

“…Catalysts 2021, 11, x FOR PEER REVIEW 7 of 34 erties of these materials, specifically those obtained by the LMS oxidation of guar polygalactomannanes, was recently investigated by Galante and coworkers and reported in a series of publications [61][62][63][64][65][66][67].…”

Section: Laccase-mediator Systems: From Alcohols Bio-oxidation To Integrated Chemoenzymatic Systemsmentioning

confidence: 99%

Biocatalysis with Laccases: An Updated Overview

et al. 2020

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Laccases are multicopper oxidases, which have been widely investigated in recent decades thanks to their ability to oxidize organic substrates to the corresponding radicals while producing water at the expense of molecular oxygen. Besides their successful (bio)technological applications, for example, in textile, petrochemical, and detoxifications/bioremediations industrial processes, their synthetic potentialities for the mild and green preparation or selective modification of fine chemicals are of outstanding value in biocatalyzed organic synthesis. Accordingly, this review is focused on reporting and rationalizing some of the most recent and interesting synthetic exploitations of laccases. Applications of the so-called laccase-mediator system (LMS) for alcohol oxidation are discussed with a focus on carbohydrate chemistry and natural products modification as well as on bio- and chemo-integrated processes. The laccase-catalyzed Csp2-H bonds activation via monoelectronic oxidation is also discussed by reporting examples of enzymatic C-C and C-O radical homo- and hetero-couplings, as well as of aromatic nucleophilic substitutions of hydroquinones or quinoids. Finally, the laccase-initiated domino/cascade synthesis of valuable aromatic (hetero)cycles, elegant strategies widely documented in the literature across more than three decades, is also presented.

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“…1 Maximum released lysozyme activity and phenolic content in distilled water were reached at the 120th hour and on the 15th day, respectively. 2 Time periods (h) of data used in the best fit were between 0 and 6 h (R 2 =0.87-0.99). 3 Time periods (h) of data used in the best fit were between 0 and 24 h (R 2 =0.56-0.71).…”

Section: Antimicrobial Activity Of Different Gels Against L Innocuamentioning

confidence: 99%

Physicochemical and Active Properties of Gelatine-Based Composite Gels Loaded with Lysozyme and Green Tea Polyphenols

Boyacı

Kavur

Güleç

et al. 2021

Food Technol. Biotechnol. (Online)

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Research background. The use of gel-based systems, as a novel method for the delivery of natural antimicrobial, antioxidant, and bioactive compounds is a developing innovative solution for the food industry. This research aimed development of multifunctional active edible gels based on gelatine and its composites with improved mechanical properties. Experimental approach. Antilisterial and bioactive composite gels showing different physical and active properties than classical gelatine gel were developed by loading lysozyme and green tea extract into gelatine/starch and gelatine/wax composite gels. The gels were characterized for their mechanical properties, swelling profiles, colour, release profiles, and antimicrobial and bioactive properties. Results and conclusions. Gelatine/wax gels showed 1.3 to 2.1-fold higher firmness and cutting strength than gelatine and gelatine/starch composite gels that had similar firmness and cutting strengths. Work to shear of both composite gels was 1.4 to 1.9-fold higher than that of gelatine gel. The gelatine/starch gel showed the highest water absorption capacity. Green tea extract reduced soluble lysozyme in gels, but composite gels contained higher soluble lysozyme than gelatine gel. All the gels with lysozyme inhibited Listeria innocua growth in the broth media while green tea extract showed antilisterial activity only in gelatine/wax gels. Gels with green tea extract showed antioxidant, antidiabetic (α-glucosidase, and α-amylase inhibition), antihypertensive (angiotensin-converting enzyme inhibition), and antiproliferative activities (on Caco-2 human colon carcinoma cells). However, gelatine and gelatine/wax gels showed the highest antioxidant and antidiabetic activity. The gelatine/wax gels prevented phenolic browning while green tea extract in other gels showed moderate or extensive browning. Novelty and scientific contribution. This work clearly showed the possibility of improving mechanical properties, and modifying water absorption and controlled release profiles of gelatine gels using gelatine/starch and gelatine/wax composites. The novel composite gels reduced browning of incorporated polyphenols and showed antilisterial and bioactive properties.

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“Aerogels of enzymatically oxidized galactomannans from leguminous plants: Versatile delivery systems of antimicrobial peptides and enzymes”

Cited by 25 publications

References 68 publications

Applications of Microbial Laccases: Patent Review of the Past Decade (2009–2019)

Applications of Microbial Laccases: Patent Review of the Past Decade (2009–2019)

Biocatalysis with Laccases: An Updated Overview

Physicochemical and Active Properties of Gelatine-Based Composite Gels Loaded with Lysozyme and Green Tea Polyphenols

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