Aeromonas infections and their treatment

Jones, Brian; Wilcox, M. H.

doi:10.1093/jac/35.4.453

Cited by 112 publications

(65 citation statements)

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“…Ciprofloxacin and norfloxacin resistance was more prevalent among A. hydrophila isolates (43% and 34%, respectively) than the other species. Commonly, quinolones are synthetic antibiotics used as first therapeutic options for Aeromonas infections in humans [29,30], also used in the treatment of bacterial fish diseases [31]. These drugs can persist for a long time in the environment, which could favor the emergence of resistant strains in environmental samples.…”

Section: Resultsmentioning

confidence: 99%

Antimicrobial Resistance Patterns of Aeromonas spp. Isolated from Ornamental Fish

Días¹,

Mota²,

Martínez‐Murcia³

et al. 2012

J Aquac Res Development

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The potential risk of occurrence of new diseases associated with the trade of live animals is well known. However, little importance is still given to the problematic of the dissemination of resistance genes that pass along with the animal trade. In this study we aimed to isolate Aeromonas spp. strains from water and skin of ornamental fish and test their resistance to antibiotics. The samples were collected from a national ornamental fish importer, with the intent of obtaining a collection of Aeromonas strains. The identification of the strains was made by gyrB and rpoD gene sequencing. A total of 288 strains grouped in seven different species -Aeromonas veronii, Aeromonas media, Aeromonas jandaei, Aeromonas hydrophila, Aeromonas caviae, Aeromonas culicicola, Aeromonas aquariorum, were isolated. The susceptibility profile was determined for 28 antibiotics commonly used. All the strains presented multi-resistance to the tested antibiotics. The antibiotic susceptibility profile to tetracycline, ticarcillin, carbenicillin, ampicillin and erythromycin revealed resistance levels of more than 80%. Few strains resistant to aztreonam and imipenem were identified. On the other hand, all were sensitive to cefotaxime and cefepime. The results show that these Aeromonas spp. strains are potentially reservoirs of antibiotic resistance genes.

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Section: Resultsmentioning

confidence: 99%

Antimicrobial Resistance Patterns of Aeromonas spp. Isolated from Ornamental Fish

Días¹,

Mota²,

Martínez‐Murcia³

et al. 2012

J Aquac Res Development

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“…Aeromonas species are Gram-negative facultative anaerobic bacteria found ubiquitously in a variety of aquatic environments (1). The main syndrome caused by infection with Aeromonas is gastroenteritis (2,3), although, in severe cases, sepsis is induced as a deuteropathy (4,5).…”

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confidence: 99%

Structural Basis for the Kexin-like Serine Protease from Aeromonas sobria as Sepsis-causing Factor

Kobayashi

Utsunomiya

Yamanaka

et al. 2009

Journal of Biological Chemistry

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The anaerobic bacterium Aeromonas sobria is known to cause potentially lethal septic shock. We recently proposed that A. sobria serine protease (ASP) is a sepsis-related factor that induces vascular leakage, reductions in blood pressure via kinin release, and clotting via activation of prothrombin. ASP preferentially cleaves peptide bonds that follow dibasic amino acid residues, as do Kex2 (Saccharomyces cerevisiae serine protease) and furin, which are representative kexin family proteases. Here, we revealed the crystal structure of ASP at 1.65 Å resolution using the multiple isomorphous replacement method with anomalous scattering. Although the overall structure of ASP resembles that of Kex2, it has a unique extra occluding region close to its active site. Moreover, we found that a nicked ASP variant is cleaved within the occluding region. Nicked ASP shows a greater ability to cleave small peptide substrates than the native enzyme. On the other hand, the cleavage pattern for prekallikrein differs from that of ASP, suggesting the occluding region is important for substrate recognition. The extra occluding region of ASP is unique and could serve as a useful target to facilitate development of novel antisepsis drugs.

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“…isolates are sensitive to the third generation of these antimicrobial drugs (Jones & Wilcox, 1995). Panigua et al (2006) established MIC of ceftriaxone of 3.9 µg/mL, and Goni-Urriza et al (2000) -16 µg/mL of cefoxitin.…”

Section: Discussionmentioning

confidence: 99%

Determination of beta-haemolytic activity and minimum inhibitory concentrations of antimicrobial drugs against Aeromonas hydrophila strains isolated from fish products

Stratev¹,

Vashin²,

Daskalov³

2015

BJVM

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SummaryStratev, D., I. Vashin & H. Daskalov, 2015. Determination of beta-haemolytic activity and minimum inhibitory concentrations of antimicrobial drugs against Aeromonas hydrophila strains isolated from fish products. Bulg. J. Vet. Med., 18, No 3,[239][240][241][242][243][244][245][246][247] The purpose of the study was to investigate the prevalence of β-haemolytic Aeromonas hydrophila strains in 83 samples from cooled horse mackerel, rainbow trout, Black sea roach, silver carp, vacuum-packed rainbow trout fillets and 20 samples frozen rainbow trout and to establish the minimum inhibitory concentrations (MIC) of several antimicrobial drugs against these strains. Forty-five Aeromonas spp. strains were isolated, 36 (80%) of them with β-haemolytic activity. Identification of biochemical properties and determination of MICs were performed with 20 β-haemolytic A. hydrophila strains. The MICs of cefoxitin (≤0.5-32 µg/mL), azithromycin (≤0.5-16 µg/mL), chloramphenicol (≤2-16 µg/mL), tetracycline (≤4-16 µg/mL), ceftriaxone (≤0.25-32 µg/mL), amoxicillin/clavulanic acid (≤8/4-32/16 µg/mL), ciprofloxacin (≤0.015-1 µg/mL), gentamicin (≤1-4 µg/mL), nalidixic acid (≤0.5-8 µg/mL), ceftiofur (≤1-8 µg/mL), sulfisoxazole (≤64-256 µg/mL), trimethoprim/ sulfamethoxazole (≤0.12/2.38-1/19 µg/mL), kanamycin (≤8-16 µg/mL) and streptomycin (≤32 µg/mL) were determined using Sensititre® CMV2AGNF microtitre plates (Trek Diagnostic Systems, USA). Tested strains were resistant to ampicillin concentrations in the plate: >32 µg/mL.

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Aeromonas infections and their treatment

Cited by 112 publications

References 0 publications

Antimicrobial Resistance Patterns of Aeromonas spp. Isolated from Ornamental Fish

Antimicrobial Resistance Patterns of Aeromonas spp. Isolated from Ornamental Fish

Structural Basis for the Kexin-like Serine Protease from Aeromonas sobria as Sepsis-causing Factor

Determination of beta-haemolytic activity and minimum inhibitory concentrations of antimicrobial drugs against Aeromonas hydrophila strains isolated from fish products

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