Each member of my committee made an essential contribution to this work. Dr. Stephen Patek, my advisor, shaped me as an academic researcher and pointed me in the right direction whenever I was lost. This research is equal parts his vision and mine. Dr. Myla Goldman, my clinical research mentor, drove our work forward and pushed me to be my best. She taught me everything I know about clinical research and inspired me as a role model and friend. Dr. John Lach brought me out of PhD seclusion to join the INERTIA team, giving me a research community. He challenged me to see the big picture and taught me how to bridge the gap between engineering and clinical impact. My chair, Dr. Peter Beling, gave me technical guidance at critical points, leading to our work in active learning. Crafting lectures and exam problems with him as a teaching fellow was perhaps the most memorable experience of graduate school. Dr. Laura Barnes has been a continual source of wisdom and support. As the expert in machine learning and health informatics, she repeatedly lead us past technical and conceptual obstacles. I am so thankful to have had the privilege of working with each of them. I'd also like to thank Dr. Gerard Learmonth, who encouraged me to apply to the PhD program, advised me in my first year, and supported me during a difficult time. I owe special thanks to Karen Schmidt, Kristina Sheridan, Josh Inouye, Stephen Adams, INERTIA, and the Goldman Lab, who supported this research with ideas, comments, and hard work. And of course I'd like to thank my family, who smiled and nodded for 8 years as I talked through one "big idea" after another. Will I ever get a real job? v