Africane-Type Sesquiterpenoids from the Argentine Liverwort Porella swartziana and Their Antibacterial Activity

Abstract

Seven africanes (1, 2a,b, 3-6), two of them new (1, 2a), three secoafricanes (7-9), one of them new (7), and two norsecoafricanes (10, 11a), one of them new (10), all of them swartzianin-type, have been isolated from an Argentine collection of the endemic liverwort Porella swartziana. The structures of the new compounds were established by extensive 1D and 2D NMR spectroscopic data. Absolute configurations of compounds 2a, 2b, and 10 were derived on the basis of CD spectra. The compounds were tested for activity against a variety of microbes, but none were found to exhibit significant antibacterial activity.

Total flavonoid concentrations of bryophytes from Tianmu Mountain, Zhejiang Province (China): Phylogeny and ecological factors

“…The total flavonoid concentrations were measured as described in our previous report [20]. A colorimetric assay was used to determine the total flavonoid content.…”

“…Bryophyte flavonoids are of great significance in research on phylogeny and metabolism [13–14]. Extracts from bryophytes which contain flavonoids have been investigated extensively for their potential pharmacological applications: cytotoxic, anticancer and antitumor [15–17], antifungal [18–19], antibacterial [20–21] and antioxidant activities, and their ability to inhibit AChE activity [22]. …”

A New Approach to Models of the 4,5‐Dihydroxycyclopentenone Core of the Kodaistatins A–D: Elucidation of the Diol Configuration in Kodaistatin A

“…In isolated rings, the motif 39 is non‐existent except in compounds 1 – 4 , cis ‐ 6 , cis ‐ and trans ‐ 7 . Annulated to an aliphatic ring the motif 39 occurs only in compounds cis ‐ and trans ‐ 40 …”

Therapeutic potential of bryophytes and derived compounds against cancer

“…obscura [71] , Ptilidium ciliare [72] , Jubula japonica [73] , Dumortiera hirsuta [74,75] , Lejeunea aquatica, Lejeunea flava and Lejeunea japonica [76] , Plagiomnium acutum [77] , Chiloscyphus polyanthus [78] , Chiloscyphus subporosus [79] , Porella swartziana [80] , Porella recurva [81] , Porella subobtusa [82] , Porella acutifolia subsp tosana [83,84] , Scapania undulata [85] , Lepicolea ochroleuca [86] , Gackstroemia sp., Dendromastigophora sp., [87] Lepidozia fauriana [88] , etc. These liverwort genera possessing sesquiterpenoid compound could be exploited as a natural source of cytotoxic compounds.…”