Ag-doped Bioactive Glass-Ceramic 3D Scaffolds: Microstructural, Antibacterial, and Biological Properties

Marsh, Adam C.; Mellott, Nathan P.; Crimp, M. A.; Wren, A.W.; Hammer, Neal D.; Chatzistavrou, Xanthippi

doi:10.1016/j.jeurceramsoc.2021.01.011

Cited by 17 publications

(10 citation statements)

References 86 publications

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“… Released ions Antibacterial mechanisms Bacteria used for antibacterial assays Ref. Alkali and alkaline earth ions CaO–P 2 O 5 –SiO 2 –RbO MBG scaffold; Forsterite scaffold Ca 2+ , Na + , Mg 2+ , Rb + Inducing the increase of solution pH and osmotic pressure S. aureus , E. coli , S. epidermidis, P. aeruginosa [ 30 , [57] , [58] , [59] , [60] , [61] , [62] ] Heavy metal ions Ag@rGO modified β-TCP scaffold Ag + Inducing ROS; Breaking bacterial cell membranes S. aureus , E.coli, Bacillus subtills [ 19 , 35 , [63] , [64] , [65] , [66] , [67] , [68] , [69] , [70] , [71] , [72] , [73] , [74] ] PCL/SiO 2 –CaO–P 2 O 5 –ZnO MBG scaffold Zn 2+ Destabilizing membrane and enhancing permeability; Deactivating nucleic acids and enzymes; Killing bacterial by inducing ROS E. coli , S. aureus [ [75] , [76] , [77] , [78] , [79] , [80] , [81] ] SiO 2 –CaO–P 2 O ...…”

Section: Bioceramic-based Scaffolds With Ion-mediated Antibacterial F...mentioning

confidence: 99%

Bioceramic-based scaffolds with antibacterial function for bone tissue engineering: A review

Zhao

Liu

Zhu

et al. 2022

Bioactive Materials

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Section: Bioceramic-based Scaffolds With Ion-mediated Antibacterial F...mentioning

confidence: 99%

Bioceramic-based scaffolds with antibacterial function for bone tissue engineering: A review

Zhao

Liu

Zhu

et al. 2022

Bioactive Materials

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“…This process is also called polymer foam replication technique (Marsh et al 2021). As the name implies, the method works by impregnating sponge or foam made of polymer that has certain porosity structure with ceramic slurry (liquid mix that contains ceramic) (Marsh et al 2021). It is suitable to produce interconnected opencell with large surface area porous ceramic.…”

Section: Replica Templatementioning

confidence: 99%

“…Viscosity of the slurry must be optimized to produced even coating, correct coating thickness and does not clog the pores. The foam is then left to dry prior to the sintering process, or it will go through the first heat treatment to remove the organic binders (Marsh et al 2021;Liang et al 2016;Bowenn and Thomas 2015). Since this method can be categorized under wet forming method which means that the ceramic is in slurry form (high binder and liquid content), thus the dry shrinkage percentage is higher for this method (Otitoju et al 2020).…”

Section: Replica Templatementioning

confidence: 99%

“…However, the gas generated from the decomposition process of the foam produces ceramic hollow struts with triangular shaped voids (Liang et al 2016) as shown in Fig. 3 (Marsh et al 2021) and the degassing stage can also create cracks at the struts for the gas to escape (Bowenn and Thomas 2015). Dwell and slower heating rate of the foam pyrolysis stage may produce gradual outgassing of the polymeric foam during degradation and consequently reduce cracking formation (Bowenn and Thomas 2015).…”

Section: Replica Templatementioning

confidence: 99%

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Synthesis of Macro Porous Ceramic Materials

Hanim

2021

Advanced Functional Porous Materials

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This chapter explored the synthesis method of macro porous ceramic by using the partial sintering, direct foaming, replica template and sacrificial template technique. The focus is to produce macro porosity in the ceramic for specific application purposes that required this porosity range. At first, fundamentals in each technique were discussed and the advancement in the topic for the recent five years was presented. This is followed by advantages and limitations existing with the current technology for each synthesizing technique. Finally, the chapter covers the possible future trends that can be explored in making the process of synthesizing macro porous ceramic to be more repeatable, stable and sustainable in the near future.

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“…The material found to be susceptible for bacterial infection, which led to its premature failure in animal model. In a previous study, silver (Ag) was doped on wollastonite scaffold due to its inherent antibacterial property [17]. The Ag-doped wollastonite scaffold exhibited a significant bacterial inhibition without inducing cytotoxicity on seeded MG-63 cells [18].…”

Section: Introductionmentioning

confidence: 99%

Antibacterial wollastonite supported excellent proliferation and osteogenic differentiation of human bone marrow derived mesenchymal stromal cells

Venkatraman

Choudhary

Krishnamurithy

et al. 2021

J Sol-Gel Sci Technol

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Biocompatibility and bacterial infections are the primary concerns associated with the current bone graft substitutes. The application of wollastonite-based scaffolds for bone tissue engineering becomes a novel subject of interest. In the present study, a single phasic wollastonite scaffold was synthesised using citric acid-based sol-gel combustion route. Its physicochemical characteristics, antibacterial properties as well as its biocompatibility and osteogenic induction effect on human bone marrow derived stromal cells (hBMSCs) are yet to be explored. The TGA/DTA, XRD and SEM/EDX confirmed the characteristics of wollastonite. The antibacterial test indicated wollastonite inhibition of 47.81% and 45.54% for gram-positive, Staphylococcus aureus and Staphylococcus epidermidis and 47.04% and 46.07% for gram-negative, Escherichia coli and Pseudomonas aeruginosa bacterial strains, respectively. The SEM micrographs demonstrated an excellent attachment of hBMSCs on wollastonite and comparable to commercial hydroxyapatite (cHA) scaffold. The alamar blue cell proliferation assay confirmed 1.7-and 1.8-fold significant increase in hBMSCs seeded on wollastonite and cHA scaffold, respectively, on day 14 as compared with day 1. The immunohistochemistry analysis on Type-I collagen (Col1) and Bone morphogenetic protein-2 (BMP2) expression on day 14 confirmed the osteogenic differentiation of hBMSCs seeded on wollastonite and comparable with cHA scaffold. In conclusion, wollastonite scaffold has a greater potential to substitute bone grafts in orthopaedic applications.

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Ag-doped Bioactive Glass-Ceramic 3D Scaffolds: Microstructural, Antibacterial, and Biological Properties

Cited by 17 publications

References 86 publications

Bioceramic-based scaffolds with antibacterial function for bone tissue engineering: A review

Bioceramic-based scaffolds with antibacterial function for bone tissue engineering: A review

Synthesis of Macro Porous Ceramic Materials

Antibacterial wollastonite supported excellent proliferation and osteogenic differentiation of human bone marrow derived mesenchymal stromal cells

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