Ag@MOF-loaded chitosan nanoparticle and polyvinyl alcohol/sodium alginate/chitosan bilayer dressing for wound healing applications

Zhang, Meng; Wang, Guohui; Wang, Dong; Zheng, Yuqi; Li, Yanxin; Meng, Wenqiao; Zhang, Xin; Du, Feifan; Lee, Shaoxiang

doi:10.1016/j.ijbiomac.2021.02.045

Cited by 123 publications

(64 citation statements)

References 41 publications

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“…The peaks at 1650 and 1722 cm −1 are attributed to C = N and C = O stretching vibration for the pyridine ring group, respectively. The peak near 779 cm −1 is assigned to Ag–O stretching vibrations, as previously reported [ 36 ]. This indicates that Ag + is coordinated to the –COOH group in the H 2 PYDC ligand rather than to the -NH group [ 36 ].…”

Section: Resultssupporting

confidence: 75%

“…The peak near 779 cm −1 is assigned to Ag–O stretching vibrations, as previously reported [ 36 ]. This indicates that Ag + is coordinated to the –COOH group in the H 2 PYDC ligand rather than to the -NH group [ 36 ].…”

Section: Resultssupporting

confidence: 75%

“…PVA/CS, PVA/Ag@MOF, and bilayer showed water retention in ascending order. This may be due to the rigid hydrophobic structure of Ag@MOF and the layered structure of bilayer hydrogels [ 36 ]. The higher water retention of the hydrogels can prevent the hydrogels from dissolving or deforming and causing negative effects on the body.…”

Section: Resultsmentioning

confidence: 99%

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Polyvinyl Alcohol/Chitosan and Polyvinyl Alcohol/Ag@MOF Bilayer Hydrogel for Tissue Engineering Applications

et al. 2021

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In this paper, polyvinyl alcohol/Ag-Metal-organic framework (PVA/Ag@MOF) and polyvinyl alcohol/chitosan (PVA/CS) were used as the inner and outer layers to successfully prepare a bilayer composite hydrogel for tissue engineering scaffold. The performance of bilayer hydrogels was evaluated. The outer layer (PVA/CS) has a uniform pore size distribution, good water retention, biocompatibility and cell adhesion ability. The inner layer (PVA/Ag@MOF) has good antibacterial activity and poor biocompatibility. PVA, PVA/0.1%Ag@MOF, PVA/0.5%Ag@MOF, and PVA/1.0%Ag@MOF show anti-microbial activity in ascending order. However, its use as an inner layer avoids direct contact with cells and prevents infection. The cell viability of all samples was above 90%, indicating that the bilayer hydrogel was non-toxic to A549 cells. The bilayer hydrogel scaffold combines the advantages of the inner and outer layers. In summary, this new bilayer composite is an ideal lung scaffold for tissue engineering.

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Section: Resultssupporting

confidence: 75%

Section: Resultssupporting

confidence: 75%

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Polyvinyl Alcohol/Chitosan and Polyvinyl Alcohol/Ag@MOF Bilayer Hydrogel for Tissue Engineering Applications

et al. 2021

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“…The CS NPs embedded in the wound dressings allow for a double sustained release to reduce the cytotoxicity and resistance of the encapsulated drug while achieving sustained healing. In addition, due to the enhanced permeability of nanoparticles for superficial diffusion, CS NPs can treat infected wounds on a large scale and promote scar-free wound healing [68][69][70][71][72]. Another instance of using CS as an active agent is the CS coatings, which provided additional antibacterial, pro-healing activity to the dressing [73][74][75].…”

Section: Scar-freementioning

confidence: 99%

Marine Polysaccharides for Wound Dressings Application: An Overview

et al. 2021

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Wound dressings have become a crucial treatment for wound healing due to their convenience, low cost, and prolonged wound management. As cutting-edge biomaterials, marine polysaccharides are divided from most marine organisms. It possesses various bioactivities, which allowing them to be processed into various forms of wound dressings. Therefore, a comprehensive understanding of the application of marine polysaccharides in wound dressings is particularly important for the studies of wound therapy. In this review, we first introduce the wound healing process and describe the characteristics of modern commonly used dressings. Then, the properties of various marine polysaccharides and their application in wound dressing development are outlined. Finally, strategies for developing and enhancing marine polysaccharide wound dressings are described, and an outlook of these dressings is given. The diverse bioactivities of marine polysaccharides including antibacterial, anti-inflammatory, haemostatic properties, etc., providing excellent wound management and accelerate wound healing. Meanwhile, these biomaterials have higher biocompatibility and biodegradability compared to synthetic ones. On the other hand, marine polysaccharides can be combined with copolymers and active substances to prepare various forms of dressings. Among them, emerging types of dressings such as nanofibers, smart hydrogels and injectable hydrogels are at the research frontier of their development. Therefore, marine polysaccharides are essential materials in wound dressings fabrication and have a promising future.

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“…Aspergillus and Penicillium produce toxic secondary metabolites during postharvest of grape, which posing to a high risk of disease for consumers and demand for natural, green and safety antibacterial agent for the preservation of grapes is growing [3]. Hydrogel antibacterial agent is the synthetic or natural biological material, which is an ideal antibacterial material [4,5]. It diffuses antibacterial molecules into the decayed area by providing a suitable microenvironment, and acts as a protective barrier at the decay interface [6].…”

Section: Introductionmentioning

confidence: 99%

Inhibitory Effect and Mechanism of Chitosan–Ag Complex Hydrogel on Fungal Disease in Grape

He¹,

Zhu²,

Chen³

et al. 2021

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Hydrogel antibacterial agent is an ideal antibacterial material because of it could diffuses antibacterial molecules into the decayed area by providing a suitable microenvironment and the hydrogel acts as a protective barrier on the decay interface. The biocompatibility and biodegradation make the removal process easily which were widely used in medical fields. However, there have been few reports on its application for controlling postharvest diseases in fruit. In this study, the Chitosan-Ag (CS-Ag) complex hydrogels were prepared using the physical crosslinking method, which used for controlling postharvest diseases in grape. The prepared hydrogels were stable for a long period at room temperature. The structure and surface morphology of CS-Ag composite hydrogels were characterized by UV-Vis, FTIR, SEM, and XRD. The inhibitory effects of CS-Ag hydrogel on disease in grape caused by P. expansum, A. niger and B. cinerea were investigated both in vivo and in vitro. The remarkable antibacterial activity of CS-Ag hydrogels was mainly due to the synergistic antibacterial and antioxidant effects of CS and Ag. Preservation test showed that the CS-Ag hydrogel had positive fresh-keeping effect. This revealed CS-Ag hydrogels plays a critical role in controlling fungal disease in grape.

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Ag@MOF-loaded chitosan nanoparticle and polyvinyl alcohol/sodium alginate/chitosan bilayer dressing for wound healing applications

Cited by 123 publications

References 41 publications

Polyvinyl Alcohol/Chitosan and Polyvinyl Alcohol/Ag@MOF Bilayer Hydrogel for Tissue Engineering Applications

Polyvinyl Alcohol/Chitosan and Polyvinyl Alcohol/Ag@MOF Bilayer Hydrogel for Tissue Engineering Applications

Marine Polysaccharides for Wound Dressings Application: An Overview

Inhibitory Effect and Mechanism of Chitosan–Ag Complex Hydrogel on Fungal Disease in Grape

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