Age changes in lymph nodes

Antibody-Forming Potential of Lymph Nodes in Aged Mice, with Special Reference to the Influence of Adjuvant

“…This is supported by the fact that in any one group of lymph nodes the same morphological picture is observed. Similar findings have been obtained in man (5,22). Denz (5), for example, summarized his experience in the statement that 'at any period the stimulus of local inflammation may cause the node to prolifer ate and take on the character of the node found in childhood'.…”

Radiologic Manifestations of Senile Lymph Nodes in the Popliteal Fossa

“…Details of morphology, function, histology, pathology, and development of lymph nodes have been presented and discussed. [1][2][3][4][6][7][8][9][10][11][12][13][14][15][16][17] Previous studies have shown that lymph nodes start developing in early embryos and are fully developed in the neck, axilla, groin, and the root of the mesentery in fetal life. 18-21 Denz (1947), 4 after studying over 300 human lymph nodes, concluded that lymph nodes reached their maximal development in childhood and decreased in size after puberty.…”

“…3 Lymph nodes gradually degenerate as people age. During this period, 4 the degenerating lymph node passes through various phases but detailed accounts of this process are poorly documented.…”

Number, size, and distribution of Peyer's patches in the human small intestine: Part II The effect of age on Peyer's patches

“…Denz (1947) showed that there was very little atrophy in the deep cervical nodes until at least 60 years of age, and that inactive germinal centres could still be found at the age of 80.…”