Age-Group-Specific Associations between the Severity of Obstructive Sleep Apnea and Relevant Risk Factors in Male and Female Patients

Abstract

AimTo seek accurate and credible correlation manner between gender, age, and obesity; and the severity of obstructive sleep apnea (OSA) in large-scale population.MethodsTotals of 1,975 male and 378 female OSA patients were sequentially recruited. Centralized covariant tendencies between age, body mass index (BMI), and waist hip ratio (WHR); and OSA severity, were explored in a gender-specific manner via multiple statistical analyses. The accuracies of observed correlations were further evaluated by adaptive multiple linear regression.ResultsAll of age, BMI, WHR, smoking, drinking, and OSA severity differed between males and females. BMI and WHR were positively and (approximately) linearly associated with OSA severity in both males and females. Restricted cubic spline analysis was more effective than was the Pearson correlation approach in correlating age with AHI, and provided age crossover points allowing further piecewise linear modeling for both males and females. Multiple linear regression showed that increasing age was associated with OSA exacerbation in males aged ≤40 years and in females aged 45–53 years. BMI, WHR, and diabetes were independently associated with OSA severity in males with age-group-specific pattern. In females, only BMI was associated with OSA severity at all ages.ConclusionsIn male patients, BMI and WHR are prominent risk factors for OSA exacerbation. Age and diabetes are associated with OSA severity in males of particular ages. In females, BMI is also a prominent risk factor for severe OSA, and OSA severity increased with age in the range 45–53 years.

Daytime Sleepiness Among Young Adult Omani Car Drivers

“…older age and high BMI) are associated with OSAS. 26 Nevertheless, the prevalence of OSAS in this sample was 10.6%, which is within the range reported by previous research (9-24%). 25 This study was subject to certain limitations, particularly as the findings were based solely on selfreported data.…”

Prevalence of Obstructive Sleep Apnoea in Patients with Hypertension: Study from a tertiary care hospital

“…The prevalence of OSA was highest between 51-60 years of age and this risk increased exponentially from 0.8% at ≤ 30 years of age to 41.7% at 51-60 years of age (p ˂ 0.001) ( Figure 2). This finding is in agreement with the previous studies demonstrating the effect of age on OSA status [19], [35].…”

Prevalence of High Risk Obstructive Sleep Apnoea by Berlin Questionnaire in Patients with Hypertension: Study from a Tertiary Care Hospital

“…(Figure 2). This nding is in agreement with the previous studies demonstrating the effect of age on OSA status (Deng et al, 2014;Ip et al, 1999).…”